CAJ | 학술논문

目的探讨系统性红斑狼疮性脑病(NPSLE)的MRI特点.方法回顾性分析21例经临床证实的NPSLE患者颅脑MRI图像,根据其DWI行ADC图重建,测量病灶及正常脑组织的ADC值并进行对照.结果 21例NPSLE患者中颅脑MRI检查发现异常者20例,阳性率为95%.MRI异常表现包括:(1)DWI高信号14例,11例多发,3例单发;14例中4例合并脑萎缩;病灶部位皮层下白质较皮层多见;皮层DWI高信号病灶ADC值减低(t=2.513,P=0.019),白质DWI高信号病灶ADC值升高(t=2.877,P=0.007).(2)单纯脑萎缩2例.(3)脑白质稀疏2例.(4)软化灶2例,其中1例合并脑萎缩.(5)5例NPSLE行MRI增强检查,2例强化,表现为沿脑回分布的条状、小片状强化.结论 MRI在判断NPSLE脑部病变的有无、部位、进展及转归中起重要作用.
목적 탐토계통성홍반랑창성뇌병(NPSLE)적MRI특점.방법 회고성분석21례경림상증실적NPSLE환자로뇌MRI도상,근거기DWI행ADC도중건,측량병조급정상뇌조직적ADC치병진행대조.결과 21례NPSLE환자중로뇌MRI검사발현이상자20례,양성솔위95%.MRI이상표현포괄:(1)DWI고신호14례,11례다발,3례단발;14례중4례합병뇌위축;병조부위피층하백질교피층다견;피층DWI고신호병조ADC치감저(t=2.513,P=0.019),백질DWI고신호병조ADC치승고(t=2.877,P=0.007).(2)단순뇌위축2례.(3)뇌백질희소2례.(4)연화조2례,기중1례합병뇌위축.(5)5례NPSLE행MRI증강검사,2례강화,표현위연뇌회분포적조상、소편상강화.결론 MRI재판단NPSLE뇌부병변적유무、부위、진전급전귀중기중요작용.
Objective To evaluate the MRI features of neuropsychiatric abnormalities in systemic lupus erythematosus(NPSLE).Methods Brain MRI images of 21 cases with NPSLE confirmed by clinic were analyzed retrospectively.ADC values of the lesions and normal brain tissue were measured.Results Brain abnormal MRI findings in 20/21 cases were found(95%)including:(1)High signal intensity on DWI in 14 cases,11 were diffuse lesions,3 were focal lesions,4 of 14 combined with brain atrophy.The lesions mostly localized in white matter.The ADC values of the lesions in gray matter were decreased(t=2.513,P=0.019),while the ADC values of the lesions in white matter were increased(t=2.877,P=0.007).(2)2 cases only showed brain atrophy.(3)Leukoaraiosis presented in 2 cases.(4)Encephalomalacie presented in 2 cases,1 accompanied with brain atrophy.(5)No enhancement(3/5)and little patchy enhancement(2/5)were observed at contrast MRI study.Conclusion MRI plays an important role in displaying cerebral lesions and the location of it,progression and succession of NPSLE.