CAJ | 학술논문

小泛素样修饰蛋白(SUMO)4是SUMO家族中新近发现的成员.SUMO的生化反应途径与泛素化有类似之处,但不同的是会使蛋白质更加稳定.而不是降解蛋白质.SUM04可能是通过核因子(NF)-kB调控机制产生作用,拮抗泛素对NF-kB抑制蛋白(IkB)α的作用.而SUM04 M55V变异可能导致SUMO化失效,泛素系统和NF-kB激活,介导免疫反应和炎性反应.并且已经得到证实的是,SUM04基因M55V的多态性与某些人群的1型糖尿病相关.现在正在进行的一些研究试图揭示其在2型精尿病发病机制中的作用.
소범소양수식단백(SUMO)4시SUMO가족중신근발현적성원.SUMO적생화반응도경여범소화유유사지처,단불동적시회사단백질경가은정.이불시강해단백질.SUM04가능시통과핵인자(NF)-kB조공궤제산생작용,길항범소대NF-kB억제단백(IkB)α적작용.이SUM04 M55V변이가능도치SUMO화실효,범소계통화NF-kB격활,개도면역반응화염성반응.병차이경득도증실적시,SUM04기인M55V적다태성여모사인군적1형당뇨병상관.현재정재진행적일사연구시도게시기재2형정뇨병발병궤제중적작용.
Small ubiquitin-related modifier (SUMO)4 is a newly found member of SUMO family. The biochemical effects of SUMO are somehow similar with those of ubiquitin, but SUMO stabilizes proteins, not degrades. The effect of SUMO4 is possibly mediated by NF-kB,with its antagonistic effect to ubiquitin. SUMO4 M55V mutation could repress sumoylation, activate ubiquitin and NF-kB, which leads to immunolog-ical responses and inflammation. It has already been verified that the polymorphism of M55V in SUMO4 is as-soeiated with type 1 diabetes in some populations. Some ongoing researches will try to explore its role in the pathogenesis of type 2 diabetes.