CAJ | 학술논문

目的探讨CT引导下经皮穿刺植入125粒子近距离内照射治疗非小细胞肺癌(NSCLC)切除术后局部复发的近期效果。方法术前活检证实为NSCLC、术后局部复发的患者32例，处方剂量为90 Gy，通过CT引导经皮穿刺植入125I粒子。在治疗前和治疗后6个月，根据CT检查比较肿瘤体积，按国际标准判定疗效。中位随访24个月（6～72个月）。结果植入粒子后，瘤体接受的平均照射剂量为153.7 Gy，D90为93.5 Gy。6个月后，完全缓解率+部分缓解率为90.6％，未发生与治疗相关的严重并发症。1年和2年的生存率分别为87％和73％，中位生存期为35个月。结论在CT引导下，125I粒子植入治疗NSCLC术后局部复发安全、微创且有效。
목적 탐토CT인도하경피천자식입125입자근거리내조사치료비소세포폐암(NSCLC)절제술후국부복발적근기효과。방법 술전활검증실위NSCLC、술후국부복발적환자32례，처방제량위90 Gy，통과CT인도경피천자식입125I입자。재치료전화치료후6개월，근거CT검사비교종류체적，안국제표준판정료효。중위수방24개월（6～72개월）。결과식입입자후，류체접수적평균조사제량위153.7 Gy，D90위93.5 Gy。6개월후，완전완해솔+부분완해솔위90.6％，미발생여치료상관적엄중병발증。1년화2년적생존솔분별위87％화73％，중위생존기위35개월。결론 재CT인도하，125I입자식입치료NSCLC술후국부복발안전、미창차유효。
Objective To evaluate the efficacy of percutaneous interstitial implantation with 125I seeds for recurrent patients of postoperative non-small cell lung carcinoma (NSCLC) guided by CT.Methods Thirty-two NLCLC patients were verified by biopsy pathology.Prescribed dose was 90 Gy.The percutaneous interstitial implantation of 125I seeds treatment was guided by CT.The carcinoma were scanned by CT and compared before and 6 months after treatment.Then judge the curative effect accerding to the curative standard put forward by World Health Organization.All the patients were folluwed-up for 6 to 72 months, mean 24 months.Results The mean radioactive dose of therapy group was 153.7 Gy, D90 was 93.5 Gy.Among the 32 follow-up cases, the complete and partial remission rate was 90.6％, and no major complications.One and two year survival rate were 87％ and 73％, mean survival was 35 months.Conclusion Percutaneous interstitial implantation with 125I seeds for recurrent patients of postoperative NSCLC guided by CT is a valid, minimally invasive and efficient method.