CAJ | 학술논문

目的探讨未经治疗的一期、二期和隐性梅毒患者外周血单核细胞亚群的变化.方法流式细胞仪检测58例未经治疗的梅毒患者(包括隐性梅毒36例,一期梅毒8例,二期梅毒14例)的外周血单核细胞CD14highSCD16-亚群和CD14+CD16+亚群.结果与正常人对照组相比.梅毒患者CD14+CD16+单核细胞所占比例明显升高,所占总单核细胞比例为12.0%±5.0%,而CD14highCD16-Mo亚群明显降低.为88.0%±5.1%,二者差异均有统计学意义.隐性梅毒、一期梅毒、二期梅毒之间CD14highCD16-亚群和CD14+CD16+亚群差异无统计学意义.结论未经治疗的梅毒患者外周血单核细胞亚群的变化可能与梅毒螺旋体的持续感染有关,与各临床分期相关性不明显.
목적 탐토미경치료적일기、이기화은성매독환자외주혈단핵세포아군적변화.방법 류식세포의검측58례미경치료적매독환자(포괄은성매독36례,일기매독8례,이기매독14례)적외주혈단핵세포CD14highSCD16-아군화CD14+CD16+아군.결과 여정상인대조조상비.매독환자CD14+CD16+단핵세포소점비례명현승고,소점총단핵세포비례위12.0%±5.0%,이CD14highCD16-Mo아군명현강저.위88.0%±5.1%,이자차이균유통계학의의.은성매독、일기매독、이기매독지간CD14highCD16-아군화CD14+CD16+아군차이무통계학의의.결론 미경치료적매독환자외주혈단핵세포아군적변화가능여매독라선체적지속감염유관,여각림상분기상관성불명현.
Objective To analyze the changes in peripheral blood monocyte subpopulations in patients with primary, secondary and latent syphilis. Methods Flow cytometry was used to detect CD14highCD16- and CD14+CD16+ monocyte subpopulations in peripheral blood from 58 patients with untreated syphilis, including 36 cases of latent syphilis,8 cases of primary syphilis and 14 cases of secondary syphilis, as well as from 65 normal human controls. Restflts Compared with the normal controls, the proportion of CD14+CD16+ monocytes among total monocytes was significantly elevated (12.0% ± 5.0% vs 6.0% ± 3.3%, t = 7.25, P < 0.01), while that of CD14highCD16- monocytes was down-regulated (88.0% ± 5.1% vs 94.0% ± 3.5%, t = -7.20, P < 0.01). No statistical difference was observed in the proportion of CD14+CD16+ or CD14hhighCD16- monocytes among the patients with primary syphilis, secondary syphilis and those with latent syphilis (all P > 0.05). Conclusions The changes in peripheral blood monocyte subpopulation in patients with untreated syphilis may be associated with the permanent infection of Treponema pallidum, but have no obvious correlation with clinical stage of syphilis.