中国实用眼科杂志
中國實用眼科雜誌
중국실용안과잡지
CHINESE JOURNAL OF PRACTICAL OPHTHALMOLOGY
2010年
11期
1218-1221
,共4页
高脂血症%白内障,年龄相关性%晶状体
高脂血癥%白內障,年齡相關性%晶狀體
고지혈증%백내장,년령상관성%정상체
Hyperlipidemia cataract%Age-related lens
目的 探讨高脂血症对年龄相关性核性白内障患者晶状体密度影响.方法 收集2007年1月至2008年12月在沈阳市第四人民医院眼科就诊的年龄相关性核性白内障患者136例(189只眼)作为研究组.其中,男59例,女77例.年龄51～91岁,平均年龄(71.3±8.6)岁.同时,随机选取同期年龄匹配的90例(180只眼)健康体检者作为对照,年龄54～83岁,平均年龄(68.9±7.4)岁.受检者抽取静脉血后检测进行血清总胆固醇(TC)、甘油三酯(TG),低密度脂蛋白胆固醇(LDLC)的测定.同时对受检者进行眼科检查,检测其晶状体密度LOCSⅢ分级和LogMAR视力.结果 年龄相关性核性白内障患者的血清TC、TG和LDLC值分别为(6.958+1.87)mmo1/L、(1.97+0.71)mmol/L和(4.17+1.83)mmol/L,均显著高于对照组的(4.26+0.78)mmol/L、(1.29+0.48)mmol/L和(2.85+0.67)mmol/L,组间差异具有统计学意义,P＜0.05.年龄相关性核性白内障患者的晶状体密度、LOCSⅢ分级分值和LogMAR视力均显著高于对照组,两组差异具有统计学意义(P＜0.01).血清TC、TG和LDLC与年龄相关性核性白内障患者晶状体密度呈正相关,其相关系数r分别为0.671、0.835和0.569.经检验,P＜0.05或0.01.结论 高脂血症能使年龄相关性核性白内障患者晶状体密度增加,是年龄相关性白内障发病的危险因素之一.
目的 探討高脂血癥對年齡相關性覈性白內障患者晶狀體密度影響.方法 收集2007年1月至2008年12月在瀋暘市第四人民醫院眼科就診的年齡相關性覈性白內障患者136例(189隻眼)作為研究組.其中,男59例,女77例.年齡51～91歲,平均年齡(71.3±8.6)歲.同時,隨機選取同期年齡匹配的90例(180隻眼)健康體檢者作為對照,年齡54～83歲,平均年齡(68.9±7.4)歲.受檢者抽取靜脈血後檢測進行血清總膽固醇(TC)、甘油三酯(TG),低密度脂蛋白膽固醇(LDLC)的測定.同時對受檢者進行眼科檢查,檢測其晶狀體密度LOCSⅢ分級和LogMAR視力.結果 年齡相關性覈性白內障患者的血清TC、TG和LDLC值分彆為(6.958+1.87)mmo1/L、(1.97+0.71)mmol/L和(4.17+1.83)mmol/L,均顯著高于對照組的(4.26+0.78)mmol/L、(1.29+0.48)mmol/L和(2.85+0.67)mmol/L,組間差異具有統計學意義,P＜0.05.年齡相關性覈性白內障患者的晶狀體密度、LOCSⅢ分級分值和LogMAR視力均顯著高于對照組,兩組差異具有統計學意義(P＜0.01).血清TC、TG和LDLC與年齡相關性覈性白內障患者晶狀體密度呈正相關,其相關繫數r分彆為0.671、0.835和0.569.經檢驗,P＜0.05或0.01.結論 高脂血癥能使年齡相關性覈性白內障患者晶狀體密度增加,是年齡相關性白內障髮病的危險因素之一.
목적 탐토고지혈증대년령상관성핵성백내장환자정상체밀도영향.방법 수집2007년1월지2008년12월재침양시제사인민의원안과취진적년령상관성핵성백내장환자136례(189지안)작위연구조.기중,남59례,녀77례.년령51～91세,평균년령(71.3±8.6)세.동시,수궤선취동기년령필배적90례(180지안)건강체검자작위대조,년령54～83세,평균년령(68.9±7.4)세.수검자추취정맥혈후검측진행혈청총담고순(TC)、감유삼지(TG),저밀도지단백담고순(LDLC)적측정.동시대수검자진행안과검사,검측기정상체밀도LOCSⅢ분급화LogMAR시력.결과 년령상관성핵성백내장환자적혈청TC、TG화LDLC치분별위(6.958+1.87)mmo1/L、(1.97+0.71)mmol/L화(4.17+1.83)mmol/L,균현저고우대조조적(4.26+0.78)mmol/L、(1.29+0.48)mmol/L화(2.85+0.67)mmol/L,조간차이구유통계학의의,P＜0.05.년령상관성핵성백내장환자적정상체밀도、LOCSⅢ분급분치화LogMAR시력균현저고우대조조,량조차이구유통계학의의(P＜0.01).혈청TC、TG화LDLC여년령상관성핵성백내장환자정상체밀도정정상관,기상관계수r분별위0.671、0.835화0.569.경검험,P＜0.05혹0.01.결론 고지혈증능사년령상관성핵성백내장환자정상체밀도증가,시년령상관성백내장발병적위험인소지일.
Objective To investigate the lens density of age-related nuclear cataract patients affected by hyperlipidemia. Methods A total of 136 cases (189 eyes) of age-related nuclear cataract patients were collected during the treatment from January 2007 to December 2008 in the Department of Ophthalmology, the Fourth People's Hospital of Shenyang, Liaoning. There were 39 male cases and 51 female cases, with the range of ages as 51-91, and averaged 71.3±8.6 years old. At the same time, 90 (180 eyes) cases of age-matched healthy persons over the same period were randomly selected as the control, with the range of ages as 54-83,and averaged 68.9±7.4 years old. For each subject, serum total cholesterol (TC), triglyceride (TG), low-density lipoprotein cholesterol (LDLC), were determined after venous blood samples were collected. Meanwhile, eye examinations were performed to determine the lens density of LOCS Ⅲ grading and LogMAR visual acuity.Results The serum TC, TG and LDLC values of age-related nuclear cataract patients were 6.958 ± 1.87 mmol / L, 1.97 ± 0.71 mmol/ L and 4.17±1.83 mmol / L, respectively, which were significantly higher than that of the control group (4.26±0.78 mmol/ L, 1.29±0.48 mmol/ L and 2.85 ± 0.67 mmol/ L) respectively. The difference between two groups was significant (P ＜0.05) or very significant (P ＜0.01). The lens density, LOCS Ⅲ grading score and LogMAR visual acuity were significantly higher than that of the control group.There were significantly statistical differences between data of two groups (P ＜0.01). There were significant positive correlation between Serum TC, TG, LDLC and lens density among age-related nuclear cataract patients, the correlation 0.569, respectively (P ＜0.05 or P ＜0.01). Conclusions Hyperlipemia can increase lens density of age-related nuclear cataract patients, and is a risk factor of age-related cataract.
