中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2011年
41期
2895-2898
,共4页
卢震海%方淯靖%伍小军%潘志忠%万德森
盧震海%方淯靖%伍小軍%潘誌忠%萬德森
로진해%방육정%오소군%반지충%만덕삼
结肠肿瘤%基质金属蛋白酶1%肿瘤分期%预后
結腸腫瘤%基質金屬蛋白酶1%腫瘤分期%預後
결장종류%기질금속단백매1%종류분기%예후
Colonic neoplasms%Matrix metalloproteinase 1%Neoplasm staging%Prognosis
目的 探讨基质金属蛋白酶1( MMP-1)在结肠癌中的表达及其结合临床分期对预后的指导意义.方法 通过免疫组织化学法对1995年1月至2003年5月中山大学肿瘤防治中心手术治疗的620例结肠癌患者的组织芯片进行MMP-1表达检测,并结合临床数据进行分析.结果 组织芯片有效结果为581例,MMP-1在结肠癌组织中的表达较在正常组织中高[72.5％ (421/581)比30.8％ (179/581),P=0.0001].组织MMP-1在Ⅰ、Ⅱ期阳性表达率高于在Ⅲ、Ⅳ期[77.6％(235/303)比66.9％(186/278),P=0.0040],在Ⅰ、Ⅱ期中表达时患者预后较差,在Ⅲ、Ⅳ期中表达时患者预后较好.COX多因素分析结果显示肿瘤MMP-1表达[危险比(HR):1.042,95％可信区间(CI):0.770～1.410,P=0.0001],肿瘤大体(HR:0.966,95％CI:0.571～1.633,P=0.0150),局部浸润(HR:0.576,95％ CI:0.413 ～0.805,P=0.0010)和肠壁浸润(HR:0.337,95％CI:0.197 ～0.575,P =0.0001)是结肠癌的预后因素.结论 MMP-1是结肠癌的独立预后因素,组织MMP-1在结肠癌不同分期的表达意义不同,其表达结合临床分期对结肠癌的预后起一定的指导意义.
目的 探討基質金屬蛋白酶1( MMP-1)在結腸癌中的錶達及其結閤臨床分期對預後的指導意義.方法 通過免疫組織化學法對1995年1月至2003年5月中山大學腫瘤防治中心手術治療的620例結腸癌患者的組織芯片進行MMP-1錶達檢測,併結閤臨床數據進行分析.結果 組織芯片有效結果為581例,MMP-1在結腸癌組織中的錶達較在正常組織中高[72.5％ (421/581)比30.8％ (179/581),P=0.0001].組織MMP-1在Ⅰ、Ⅱ期暘性錶達率高于在Ⅲ、Ⅳ期[77.6％(235/303)比66.9％(186/278),P=0.0040],在Ⅰ、Ⅱ期中錶達時患者預後較差,在Ⅲ、Ⅳ期中錶達時患者預後較好.COX多因素分析結果顯示腫瘤MMP-1錶達[危險比(HR):1.042,95％可信區間(CI):0.770～1.410,P=0.0001],腫瘤大體(HR:0.966,95％CI:0.571～1.633,P=0.0150),跼部浸潤(HR:0.576,95％ CI:0.413 ～0.805,P=0.0010)和腸壁浸潤(HR:0.337,95％CI:0.197 ～0.575,P =0.0001)是結腸癌的預後因素.結論 MMP-1是結腸癌的獨立預後因素,組織MMP-1在結腸癌不同分期的錶達意義不同,其錶達結閤臨床分期對結腸癌的預後起一定的指導意義.
목적 탐토기질금속단백매1( MMP-1)재결장암중적표체급기결합림상분기대예후적지도의의.방법 통과면역조직화학법대1995년1월지2003년5월중산대학종류방치중심수술치료적620례결장암환자적조직심편진행MMP-1표체검측,병결합림상수거진행분석.결과 조직심편유효결과위581례,MMP-1재결장암조직중적표체교재정상조직중고[72.5％ (421/581)비30.8％ (179/581),P=0.0001].조직MMP-1재Ⅰ、Ⅱ기양성표체솔고우재Ⅲ、Ⅳ기[77.6％(235/303)비66.9％(186/278),P=0.0040],재Ⅰ、Ⅱ기중표체시환자예후교차,재Ⅲ、Ⅳ기중표체시환자예후교호.COX다인소분석결과현시종류MMP-1표체[위험비(HR):1.042,95％가신구간(CI):0.770～1.410,P=0.0001],종류대체(HR:0.966,95％CI:0.571～1.633,P=0.0150),국부침윤(HR:0.576,95％ CI:0.413 ～0.805,P=0.0010)화장벽침윤(HR:0.337,95％CI:0.197 ～0.575,P =0.0001)시결장암적예후인소.결론 MMP-1시결장암적독립예후인소,조직MMP-1재결장암불동분기적표체의의불동,기표체결합림상분기대결장암적예후기일정적지도의의.
Objective To explore the expression patterns of matrix metalloproteinasel ( MMP-1 ) in colon carcinoma and evaluate its clinical significance.Methods The expression of MMP-1 was detected by SP immunohistochemical method.The tissue microarray samples of 620 colon carcinoma patients were collected and the clinical data reviewed.Results The positive expression rate of MMP-1 in cancer tissue was higher than that of normal tissue [72.5％ (421/581) vs 30.8％ ( 179/581 ),P =0.0001 ].And the difference was statistically significant (P =0.0001 ).The positive rate in stages Ⅰ and Ⅱ [ 77.6％(235/303) ] were higher than stages Ⅲ and Ⅳ [66.9％ (186/278),P=0.0040],the former two stages showed a poor prognosis while the latter two stages a fair prognosis.The results of COX regression showed that a lower expression of MMP-1 ( HR:1.042,95％ CI:0.770 - 1.410,P =0.0001 ),tumor type( HR:0.966,95％ CI:0.571 -1.633,P=0.0150),local infiltration(HR:0.576,95％ CI:0.413-0.805,P=0.0010) and infiltration of bowel wall (HR:0.337,95％ CI:0.197-0.575,P =0.0001 )were significant predictors of colon carcinoma.Conclusion As an independent prognostic factor of colon carcinoma,the expression of MMP-1 in cancer tissue has different prognostic implications according to various stages.
