中华医学杂志
中華醫學雜誌
중화의학잡지
National Medical Journal of China
2011年
2期
95-99
,共5页
李素华%徐新娟%梁晓慧%马岩萍%张俊仕%孙理华
李素華%徐新娟%樑曉慧%馬巖萍%張俊仕%孫理華
리소화%서신연%량효혜%마암평%장준사%손리화
肾小球滤过率%中心动脉压%健康人群
腎小毬濾過率%中心動脈壓%健康人群
신소구려과솔%중심동맥압%건강인군
Glomerular filtration rate%Central aortic pressure%Healthy population
目的 了解维吾尔族健康人群肾功能与年龄及中心动脉压(CAP)的关系.方法 于2009年7至8月从新疆和田地区,筛选临床健康居民638名,依据年龄分为4组(＜30岁、30～岁、45～岁、≥60岁)检测血压、血肌酐等指标,用中国人校正的MDRD公式估算的肾小球滤过率(eGFR),用澳大利亚PWA仪测定CAP,主要包括中心收缩压(C-SBP)、中心脉压(C-PP)、增强压(AP)、增压指数(AIX)等组分.结果 随着年龄的增长,CAP和肱动脉压均呈增高的趋势,肾功能随增龄减退;肾功能及AP、AIX的增龄改变存在性别差异(P＜0.05);在各年龄组中,女性的AP及AIX升高更为明显(P＜0.01);高AIX人群比低AIX人群年龄偏大(52±12岁比44±13岁,P=0.000),肾功能减退明显[eGFR(121±25)m1.min.(1.73 m2)-1比(131±33)ml.min.(1.73 m2)-1,P=0.000],且C-PP和AP增高明显(P=0.00);多元回归分析显示eGFR和AIX呈负相关(P＜0.01),与肱动脉压无关(P＞0.05).结论 中心动脉压与肾功能的生理性衰退相关,在老年人群中进行中心动脉压监测,有助于筛选高危肾脏疾病人群,为临床探讨保护肾脏衰老的措施提供新的治疗理念和途径.
目的 瞭解維吾爾族健康人群腎功能與年齡及中心動脈壓(CAP)的關繫.方法 于2009年7至8月從新疆和田地區,篩選臨床健康居民638名,依據年齡分為4組(＜30歲、30～歲、45～歲、≥60歲)檢測血壓、血肌酐等指標,用中國人校正的MDRD公式估算的腎小毬濾過率(eGFR),用澳大利亞PWA儀測定CAP,主要包括中心收縮壓(C-SBP)、中心脈壓(C-PP)、增彊壓(AP)、增壓指數(AIX)等組分.結果 隨著年齡的增長,CAP和肱動脈壓均呈增高的趨勢,腎功能隨增齡減退;腎功能及AP、AIX的增齡改變存在性彆差異(P＜0.05);在各年齡組中,女性的AP及AIX升高更為明顯(P＜0.01);高AIX人群比低AIX人群年齡偏大(52±12歲比44±13歲,P=0.000),腎功能減退明顯[eGFR(121±25)m1.min.(1.73 m2)-1比(131±33)ml.min.(1.73 m2)-1,P=0.000],且C-PP和AP增高明顯(P=0.00);多元迴歸分析顯示eGFR和AIX呈負相關(P＜0.01),與肱動脈壓無關(P＞0.05).結論 中心動脈壓與腎功能的生理性衰退相關,在老年人群中進行中心動脈壓鑑測,有助于篩選高危腎髒疾病人群,為臨床探討保護腎髒衰老的措施提供新的治療理唸和途徑.
목적 료해유오이족건강인군신공능여년령급중심동맥압(CAP)적관계.방법 우2009년7지8월종신강화전지구,사선림상건강거민638명,의거년령분위4조(＜30세、30～세、45～세、≥60세)검측혈압、혈기항등지표,용중국인교정적MDRD공식고산적신소구려과솔(eGFR),용오대리아PWA의측정CAP,주요포괄중심수축압(C-SBP)、중심맥압(C-PP)、증강압(AP)、증압지수(AIX)등조분.결과 수착년령적증장,CAP화굉동맥압균정증고적추세,신공능수증령감퇴;신공능급AP、AIX적증령개변존재성별차이(P＜0.05);재각년령조중,녀성적AP급AIX승고경위명현(P＜0.01);고AIX인군비저AIX인군년령편대(52±12세비44±13세,P=0.000),신공능감퇴명현[eGFR(121±25)m1.min.(1.73 m2)-1비(131±33)ml.min.(1.73 m2)-1,P=0.000],차C-PP화AP증고명현(P=0.00);다원회귀분석현시eGFR화AIX정부상관(P＜0.01),여굉동맥압무관(P＞0.05).결론 중심동맥압여신공능적생이성쇠퇴상관,재노년인군중진행중심동맥압감측,유조우사선고위신장질병인군,위림상탐토보호신장쇠로적조시제공신적치료이념화도경.
Objective To study the relationship between the decline of age-related renal function and central arterial pressure (CAP) in Uygur healthy population. Methods A total of 638 healthy Uygur inhabitants from Hetian region, Xinjiang province were enrolled. They were divided into 4 groups according to their ages. Their blood pressure, serum creatinine and other indicators were detected. eGFR (estimated glomerular filtration rate) was calculated by the formula of Chinese-based MDRD (Modification of Diet in Renal Disease). CAP was measured by a pulse wave analyzer including central arterial systolic blood pressure (C-SBP), central arterial pulse pressure (C-PP), augmentation pressure (AP), augmentation index (AIX) and other components. Results CAP and brachial arterial pressure tended to increase and renal function declined with age. There were gender differences in renal function. Both AP and AIX changed with age ( P ＜ 0. 05 ). In each group, AP and AIX increased even more significantly in females ( P ＜ 0. 01 ).The average age of subjects with a high AIX was 52 y ± 12 y. And it was elder than that of those with a low AIX (44 y ± 13 y, P =0. 000). The renal function of those with a high AIX was lower than those with a low AIX [(121 ±25) ml. min. (1.73 m2) -1]vs (131 ±33) ml. min. (1.73 m2) -1, P=0. 000]. The levels of C-PP and AP were much higher in those with a high AIX ( P = 0. 00). The results of multivariate analysis showed that eGFR was negatively correlated with the level of AIX ( P ＜ 0. 01 ). And it had no relationship with the brachial artery pressure ( P ＞ 0. 05 ). Conclusion Central arterial pressure is associated with the decline of age-related renal function. Monitoring of CAP may help to screen the high-risk patients in the elderly population. This study provides rationales for new therapeutics of protecting the aging of kidneys.
