中国实用医刊
中國實用醫刊
중국실용의간
CENTRAL PLAINS MEDICAL JOURNAL
2011年
22期
42-45
,共4页
刘若丹%钟碧玲%李亦明%王明贵%陈艳宇
劉若丹%鐘碧玲%李亦明%王明貴%陳豔宇
류약단%종벽령%리역명%왕명귀%진염우
垂体瘤转化基因%Ki67%大肠癌%免疫组织化学
垂體瘤轉化基因%Ki67%大腸癌%免疫組織化學
수체류전화기인%Ki67%대장암%면역조직화학
Pituitary tumor transforming gene%Ki67%Colorectal cancer%Immunohistochemistry
目的 研究垂体瘤转化基因(PTTG)与Ki67在大肠癌组织中的表达,探讨它们与大肠癌发生、侵袭及转移的相关性,以及它们之间的相互联系.方法 应用免疫组织化学检测42例大肠癌组织和癌旁正常组织中PTTG、Ki67的表达.结果 PTTG、Ki67在大肠癌与正常组织中的表达程度比较差异均有统计学意义,大肠癌组织中PTTG及Ki67表达阳性率分别为88.1％和100％,显著高于正常大肠组织中的表达,差异有统计学意义(P＜0.05).PTTG的表达与大肠癌患者肿瘤分型、肿瘤分化程度、肿瘤的部位未见相关(P＞0.05),而在大肠癌组织中伴转移组中显著高于无转移组(P＜0.05).Ki67的表达与大肠癌患者肿瘤分型、肿瘤分化程度、有无伴转移、肿瘤的部位未见相关(P＞0.05).大肠癌组织中PTTG的表达与Ki67的表达无相关性.结论 大肠癌组织中高表达PTTG可以反映大肠癌发展程度及转移状态,与淋巴结转移密切相关,PTTG与Ki67无相关性.PTTG可作为判断大肠癌潜在淋巴结转移和预测预后的指标之一.
目的 研究垂體瘤轉化基因(PTTG)與Ki67在大腸癌組織中的錶達,探討它們與大腸癌髮生、侵襲及轉移的相關性,以及它們之間的相互聯繫.方法 應用免疫組織化學檢測42例大腸癌組織和癌徬正常組織中PTTG、Ki67的錶達.結果 PTTG、Ki67在大腸癌與正常組織中的錶達程度比較差異均有統計學意義,大腸癌組織中PTTG及Ki67錶達暘性率分彆為88.1％和100％,顯著高于正常大腸組織中的錶達,差異有統計學意義(P＜0.05).PTTG的錶達與大腸癌患者腫瘤分型、腫瘤分化程度、腫瘤的部位未見相關(P＞0.05),而在大腸癌組織中伴轉移組中顯著高于無轉移組(P＜0.05).Ki67的錶達與大腸癌患者腫瘤分型、腫瘤分化程度、有無伴轉移、腫瘤的部位未見相關(P＞0.05).大腸癌組織中PTTG的錶達與Ki67的錶達無相關性.結論 大腸癌組織中高錶達PTTG可以反映大腸癌髮展程度及轉移狀態,與淋巴結轉移密切相關,PTTG與Ki67無相關性.PTTG可作為判斷大腸癌潛在淋巴結轉移和預測預後的指標之一.
목적 연구수체류전화기인(PTTG)여Ki67재대장암조직중적표체,탐토타문여대장암발생、침습급전이적상관성,이급타문지간적상호련계.방법 응용면역조직화학검측42례대장암조직화암방정상조직중PTTG、Ki67적표체.결과 PTTG、Ki67재대장암여정상조직중적표체정도비교차이균유통계학의의,대장암조직중PTTG급Ki67표체양성솔분별위88.1％화100％,현저고우정상대장조직중적표체,차이유통계학의의(P＜0.05).PTTG적표체여대장암환자종류분형、종류분화정도、종류적부위미견상관(P＞0.05),이재대장암조직중반전이조중현저고우무전이조(P＜0.05).Ki67적표체여대장암환자종류분형、종류분화정도、유무반전이、종류적부위미견상관(P＞0.05).대장암조직중PTTG적표체여Ki67적표체무상관성.결론 대장암조직중고표체PTTG가이반영대장암발전정도급전이상태,여림파결전이밀절상관,PTTG여Ki67무상관성.PTTG가작위판단대장암잠재림파결전이화예측예후적지표지일.
Objective To study the expression of pituitary tumor transforming gene (PTTG) in colorectal cancer,and investigate its relationship with Ki67,and probe their relation to the progression and metastasis of colorectal cancer.Methods Immunochemical staining was performed to detect the expression of PTTG and Ki67 in 42 cases of colorectal cancer tissues and 42 cases of normal control tissues.Results The positive rate of PTTG and Ki67 were 88.1％ and 100％ in colorectal cancer tissues.The positive rate and expression grade in colorectal cancer tissues were significantly higher than that in normal control tissues (P ＜ 0.01 ).No relationship between expression of PTTG and tumor typing or differentiated of colorectal cancer ( P ＞ 0.05),but expression of PTTG in metastasis group was much higher than negative group (P ＜ 0.05 ).No relationship between expression of Ki67 and tumor typing,metastasis or differentiated of colorectal cancer (P ＞ 0.05 ),PTTG showed no association with the expression of Ki67.Conclusions The expression of PTTG,is associated with the progression and metastasis of colorectal cancer,and PTTG may be used as molecular markers for judging the metastasis potential and the invasion of colorectal cancer.
