CAJ | 학술논문

目的评价西地那非在干预男性肾移植受者手术前后勃起功能时的有效性及安全性.方法选取年龄23～58岁、移植肾存活1年以上、血肌酐在移植后1年内维持在150 μmol/L以下的成年男性肾移植受者41人,所有患者在血液透析期间及移植后均口服两地那非两月,对患者血液透析期间、移植后6月及1年的勃起功能进行调查(依据国际问卷表IIEF-5),记录其各个时段的环孢素浓度、血压及血肌酐.结果肾移植前与移植后6月及1年患者的ED发生率相比,有显著性差异(P<0.05);不论血液透析期间还是移植后,西地那非治疗后的勃起功能与服药前勃起功能相比,有显著性差异(P<0.05);不论血液透析期间还是移植后,西地那非治疗后的环孢素浓度、血压及肌酐与服药前组相比,无显著性差异(P>0.05).结论肾移植后,患者的勃起功能得到了改善:不论对于尿毒症血液透析患者,还是肾移植受者,西地那非都可以改善患者的勃起功能,而且两地那非的应用具有安全性.
목적 평개서지나비재간예남성신이식수자수술전후발기공능시적유효성급안전성.방법 선취년령23～58세、이식신존활1년이상、혈기항재이식후1년내유지재150 μmol/L이하적성년남성신이식수자41인,소유환자재혈액투석기간급이식후균구복량지나비량월,대환자혈액투석기간、이식후6월급1년적발기공능진행조사(의거국제문권표IIEF-5),기록기각개시단적배포소농도、혈압급혈기항.결과 신이식전여이식후6월급1년환자적ED발생솔상비,유현저성차이(P<0.05);불론혈액투석기간환시이식후,서지나비치료후적발기공능여복약전발기공능상비,유현저성차이(P<0.05);불론혈액투석기간환시이식후,서지나비치료후적배포소농도、혈압급기항여복약전조상비,무현저성차이(P>0.05).결론 신이식후,환자적발기공능득도료개선:불론대우뇨독증혈액투석환자,환시신이식수자,서지나비도가이개선환자적발기공능,이차량지나비적응용구유안전성.
Objective To evaluate the validity and safety of Sildenafil in erectile fuction intervation of male kidney transplant recipients. Methods Forty-one married males (aged 23～58 years), who had received kidney transplantation at least one year ago and whose serum creatinine level was less than 150 μmol/L, were enrolled in the study. All patients received oral Sildenafil citrate for 2 months during the period of both undergoing hemodialysis and after transplantation. Their erectile function was investigated in the period of undergoing hemodialysis, six months after kidney transplantion and twelve months after kidney transplantion. The concentration of ciclosporin, blood pressure and serum creatinine were recorded before and after taking Sildenafil. Results There was significant difference in IIEF score after transplantion than in those undergoing hemodialysis (P<0.05); During the period both undergoing hemodialysis and after transplantation, IIEF have significant difference in the patients before and after Sildenafil-taking (P<0.05); Concentration of ciclosporin, blood pressure and serum creatinine have no significant difference before and after taking Sildenafil(P>0.05). Conclusion Erectile function can be improved after kidney transplantion. During the period both undergoing hemodialysis and after transplantion, sildenafil is an effective and safe agent in improving erectile function in kidney transplant recipients.