CAJ | 학술논문

为明确家蚕雌蛾的药用价值,采用腹腔注射四氧嘧啶法建立抗氧化模型小鼠,灌胃给予不同剂量的家蚕雌蛾粉,通过对小鼠血清及肝脏的超氧化物歧化酶(SOD)、丙二醛(MDA)、谷胱甘肽过氧化物酶(GSH-Px)等生化指标测定,研究家蚕雌蛾粉的体内抗氧化作用.结果表明家蚕雌蛾粉可明显降低模型小鼠血清及肝脏的MDA含量,高剂量组(8 g/kg)的MDA含量降低至正常对照组的水平,家蚕雌蛾粉还可提高模型小鼠血清及肝脏的SOD、GSH-Px活性,中剂量(4 g/kg)、高剂量组的提高幅度达极显著水平.实验结果提示家蚕雌蛾粉具有明显的体内抗氧化作用.
위명학가잠자아적약용개치,채용복강주사사양밀정법건립항양화모형소서,관위급여불동제량적가잠자아분,통과대소서혈청급간장적초양화물기화매(SOD)、병이철(MDA)、곡광감태과양화물매(GSH-Px)등생화지표측정,연구가잠자아분적체내항양화작용.결과표명가잠자아분가명현강저모형소서혈청급간장적MDA함량,고제량조(8 g/kg)적MDA함량강저지정상대조조적수평,가잠자아분환가제고모형소서혈청급간장적SOD、GSH-Px활성,중제량(4 g/kg)、고제량조적제고폭도체겁현저수평.실험결과제시가잠자아분구유명현적체내항양화작용.
In order to investigate the medicinal value of female silkworm moth powder, alloxan was used to prepare antioxidation model mice through intraperitoneal injection. The model mice were then intragastrically administered with different doses of the female silkworm moth powder. The antioxidation effects of female silkworm moth powder were determined in terms of superoxide dismutase (SOD) activity, malondiadehyde (MDA) content and glutathione peroxidase (GSH-Px) activity in serum and liver of the model mice in vivo. The results showed that the female silkworm moth powder could reduce MDA content in mouse serum and liver obviously. In high dosage group (8 g/kg), MDA content was lowered to the level of normal control group. Moreover, female silkworm moth powder could increase activities of SOD and GSH-Px in serum and liver of the model mice. The increases in middle dosage group (4 g/kg) and high dosage group reached extremely significant level. The above results indicate that female silkworm moth powder has remarkable in vivo antioxidation effect.