国际生物医学工程杂志
國際生物醫學工程雜誌
국제생물의학공정잡지
INTERNATIONAL JOURNAL OF BIOMEDICAL ENGINEERING
2010年
4期
201-204,211
,共5页
海马CA3%突触缺失%类Hopfield网络模型%自联想记忆%异联想记忆
海馬CA3%突觸缺失%類Hopfield網絡模型%自聯想記憶%異聯想記憶
해마CA3%돌촉결실%류Hopfield망락모형%자련상기억%이련상기억
Hippocampal CA3%Synaptic deletion%Hopfield-like neural network%Autoassociative memory%Heteroassociative memory
目的 建立1个类Hopfield脉冲神经网络模型,仿真海马中突触缺失导致的其联想记忆功能障碍.方法 根据海马CA3区的解剖结构,建立1个具有自联想记忆功能和异联想记忆功能的3层类Hopfield脉冲神经网络模型,并用Matlab对网络的2种联想记忆功能进行仿真,并根据Ruppin的‘突触缺失'理论,仿真了由突触缺失导致的CA3区联想记忆功能障碍.结果 随着突触缺失水平的增加,网络的2种联想记忆能力均下降.结论 海马CA3区神经元突触缺失不仅导致其自联想记忆能力下降,也会导致其异联想记忆能力下降.
目的 建立1箇類Hopfield脈遲神經網絡模型,倣真海馬中突觸缺失導緻的其聯想記憶功能障礙.方法 根據海馬CA3區的解剖結構,建立1箇具有自聯想記憶功能和異聯想記憶功能的3層類Hopfield脈遲神經網絡模型,併用Matlab對網絡的2種聯想記憶功能進行倣真,併根據Ruppin的‘突觸缺失'理論,倣真瞭由突觸缺失導緻的CA3區聯想記憶功能障礙.結果 隨著突觸缺失水平的增加,網絡的2種聯想記憶能力均下降.結論 海馬CA3區神經元突觸缺失不僅導緻其自聯想記憶能力下降,也會導緻其異聯想記憶能力下降.
목적 건립1개류Hopfield맥충신경망락모형,방진해마중돌촉결실도치적기련상기억공능장애.방법 근거해마CA3구적해부결구,건립1개구유자련상기억공능화이련상기억공능적3층류Hopfield맥충신경망락모형,병용Matlab대망락적2충련상기억공능진행방진,병근거Ruppin적‘돌촉결실'이론,방진료유돌촉결실도치적CA3구련상기억공능장애.결과 수착돌촉결실수평적증가,망락적2충련상기억능력균하강.결론 해마CA3구신경원돌촉결실불부도치기자련상기억능력하강,야회도치기이련상기억능력하강.
Objective A spiking Hopfield-like neural network was proposed and used to simulate the disorder of hippocampal associative memory disorder caused by synaptic deletion.Methods A three-layered Hopfield-like spiking neural network model with auto-associative memory function and hetero-associative memory function was proposed according to anatomical structure of hippocampal CA3,and both associative memories of the models were simulated under Matlab platform.Disorder of hippocampal associative memory was also simulated according to Ruppin's 'synaptic deletion' theory.Results With the increasing of synaptic deletion level,both associative memory functions impaired gradually.Conclusion Synaptic deletion of hippocampal CA3 region can lead to the disorder of autoassociative memory as well as heteroassociative memory.
