CAJ | 학술논문

目的研究乳糜泻在中国慢性腹泻患儿中的发病情况.方法收集2005年1月至2008年12月上海、济南、武汉、成都等地的慢性腹泻住院患儿进行临床多中心研究.详细记录所有患儿的病史、营养发育情况及相关辅助检查.数据处理采用SPSS11.5统计软件统计.结果共收集慢性腹泻患儿199例,纳入研究者118例,疑似乳糜泻的患儿14例(12%),其中1例确诊.去麸质饮食治疗有效.疑似病例男女比为12∶2.年龄6个月～12岁.14例疑似患儿中6例伴随营养不良,4例伴有贫血.内镜诊断十二指肠黏膜绒毛萎缩4例,病理分期Ⅰ期1例,Ⅱ期2例,Ⅲa期7例,Ⅲb期3例,Ⅲc期1例.结论本研究第一次在中国慢性腹泻儿童中进行乳糜泻的筛查,研究发现疑似乳糜泻患儿14例,占慢性腹泻儿童的12%,确诊1例.乳糜泻确实在中国儿童中存在,应该引起中国儿科医师的重视.
목적 연구유미사재중국만성복사환인중적발병정황.방법 수집2005년1월지2008년12월상해、제남、무한、성도등지적만성복사주원환인진행림상다중심연구.상세기록소유환인적병사、영양발육정황급상관보조검사.수거처리채용SPSS11.5통계연건통계.결과공수집만성복사환인199례,납입연구자118례,의사유미사적환인14례(12%),기중1례학진.거부질음식치료유효.의사병례남녀비위12∶2.년령6개월～12세.14례의사환인중6례반수영양불량,4례반유빈혈.내경진단십이지장점막융모위축4례,병리분기Ⅰ기1례,Ⅱ기2례,Ⅲa기7례,Ⅲb기3례,Ⅲc기1례.결론본연구제일차재중국만성복사인동중진행유미사적사사,연구발현의사유미사환인14례,점만성복사인동적12%,학진1례.유미사학실재중국인동중존재,응해인기중국인과의사적중시.
Objectives To investigate the prevalence of celiac disease in children with chronic diarrhea in China.Methods Inpatients of the pediatric hospitals in Shanghai,Jinan,Wuhan and Chengdu who were diagnosed as chronic diarrhea were recruited from Jan.2005 to Dec.2008.Their clihical history,physical examination and laboratory data were collected.The SPSS version 11.5 statistical package for Microsoft Windows was used for statistical analysis.Results Data of 199 patients and finally enrolled 118 hospitalized chronic diarrhea inpatients during the observation period were collected and 14(12%)of the chronic diarrhea Patients were suspected as having celiac disea8e and in one the diagnosis of celiac disease was confirmed.Gluten-free diet(CFD)treatment was effective.M/F:12/2,the age ranged from 6 months to 12 years;43%(6/14)had malnutrition,29%(4/14)had anemia,villous atrophy was found in 4 patients by endoscopy.Duodenal biopsies revealed stage Ⅰ in 1,stage Ⅱ in 2,stage Ⅲa in 7,stage Ⅲb in 3 and stage Ⅲc in 1 patient according to the modified Marsh classification.Conclusion This study was the first time to report the research of celiac disease in children with chronic diarrhea in China.The percentage of suspicious celiac disease patients was 12%(14/118)in children and one was confirmed.CD exists in China.Chinese pediatricians should pay attention to the disease.