CAJ | 학술논문

目的通过检测HCC血清中的GP73和AFP含量,探讨GP73对于肝癌检测的应用价值.方法通过ELISA方法对81例HCC、72例CH/LC和65例正常对照血清行GP73检测,并通过ROC曲线计算GP73诊断肝癌的敏感性和特异性.结果 HCC组、CH/LC组和正常对照组GP73含量分别为( 152.67±33.59) ng/ml、(93.15±20.02) ng/ml和(58.95±17.29) ng/ml.ROC曲线分析显示以120 ng/ml为Cut-off值,GP73诊断肝癌的敏感性为77.80％,特异性为78.00％.结论 GP73可以作为诊断肝癌的血清标志物,其敏感性好于AFP,同时通过联合检查可以提高肝癌的检出率,有一定的临床意义.
목적 통과검측HCC혈청중적GP73화AFP함량,탐토GP73대우간암검측적응용개치.방법 통과ELISA방법대81례HCC、72례CH/LC화65례정상대조혈청행GP73검측,병통과ROC곡선계산GP73진단간암적민감성화특이성.결과 HCC조、CH/LC조화정상대조조GP73함량분별위( 152.67±33.59) ng/ml、(93.15±20.02) ng/ml화(58.95±17.29) ng/ml.ROC곡선분석현시이120 ng/ml위Cut-off치,GP73진단간암적민감성위77.80％,특이성위78.00％.결론 GP73가이작위진단간암적혈청표지물,기민감성호우AFP,동시통과연합검사가이제고간암적검출솔,유일정적림상의의.
Objective To explore the diagnostic value of the measurement of serum Golgi protein 73 (GP73) in the diagnoeis of hepatocellular carcinoma (HCC).Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum GP73 in the 81 cases of HCC,71 cases of chronic hepatitis or cirrhosis (CH/LC) and 65 cases of healthy blood donors,and to evaluate the sensitivity and specificity in the diagnosis of HCC through the ROC curves.Results The average levels of serum GP73 in HCC,CH/LC and Normal groups were ( 152.67 ± 33.59 ) ng/ml,( 93.15 ± 20.02 ) ng/ml and ( 58.95 ± 17.29 ) ng/ml.After calculating through the ROC curves,120 ng/ml was set as the optimal cut-off point,GP73 has a sensitivity of 77.80％ and a specificity of 78.00％.Conclusions GP73 as a serum marker in the diagnosis of HCC had a higher sensitivity than AFP,and the combined detection of GP73 and AFP could improve HCC diagnosis,.