CAJ | 학술논문

目的观察胰腺癌患者血清肿瘤标志物的表达,分析其对胰腺癌诊断与预后判断的价值.方法采用化学发光法检测95例胰腺癌患者AFP、CEA、CA199、CA125和酶联免疫吸附方法检测CA242,并与80例其他系统恶性肿瘤患者和65例良性疾病患者作比较,同时对不同TNM分期的胰腺癌的五个指标比较.结果 5种肿瘤标志物中CA199、CA125、CA242对胰腺癌的诊断有较高价值,其中CA199价值最高,灵敏度和特异度分别为76.2%和74.8%.CA199、CA242、CA125随着胰腺癌的病程进展而逐步升高.结论血清CA199、C242和CA125的检测对胰腺癌的诊断和判断预后有价值.
목적 관찰이선암환자혈청종류표지물적표체,분석기대이선암진단여예후판단적개치.방법 채용화학발광법검측95례이선암환자AFP、CEA、CA199、CA125화매련면역흡부방법검측CA242,병여80례기타계통악성종류환자화65례량성질병환자작비교,동시대불동TNM분기적이선암적오개지표비교.결과 5충종류표지물중CA199、CA125、CA242대이선암적진단유교고개치,기중CA199개치최고,령민도화특이도분별위76.2%화74.8%.CA199、CA242、CA125수착이선암적병정진전이축보승고.결론 혈청CA199、C242화CA125적검측대이선암적진단화판단예후유개치.
Objective To investigate the expression of serum tumor markers in pancreatic carcinoma and to assess the value of serum tumor markers in the diagnosis and prognosis of pancreatic carcinoma. Methods Five serum tumor markers including AFP, CEA, CA199, CA125 and CA242 were detected in 95 patients with pancreatic carcinoma by chemi-luminescence immunoassay (CLI) and enzyme linked immunosorbent assay (ELISA), 80 patients with other malignant tumor and 65 patients with benign disease served as controls. Five tumor markers in pancreatic carcinoma diagnosis for TNM staging were compared. The value of tumor markers for prognosis was analyzed. Results Among these 5 kinds of tumor marker, CA199, CAI25, CA242 were valuable in diagnosis of pancreatic carcinoma, and CA199 was the most valuable one, whose sensitivity and specificity were 76.2 % and 74.8 % respectively. CA199, CA125, CA242 were increased with progression of pancreatic carcinoma. Conclusion Serum CA199, CA125 and CA242 are the preferred tumor markers to be used in the diagnosis and prognosis of pancreatic carcinoma.