CAJ | 학술논문

目的:观察和比较针刺"内关"、静脉注射一氧化氮(NO)前体L-精氨酸(L-Arg)以及两者联合应用对急性心肌缺血(AMI)大鼠的不同改善效应.方法:采用结扎左冠状动脉前降支建立AMI模型,随机设立对照组、AMI组、LArg治疗组、针刺"内关"治疗组、LArg加针刺"内关"治疗组,观察平均动脉压(MAP)、心率(HR)和心功能多项指标的变化.结果:AMI组以上各项指标较正常对照组明显降低,而各治疗组以上各项指标均有不同程度的改善,其中针药结合治疗组改善最显著.结论:LArg加针刺内关联合应用对AMI有更好的治疗效果.
목적:관찰화비교침자"내관"、정맥주사일양화담(NO)전체L-정안산(L-Arg)이급량자연합응용대급성심기결혈(AMI)대서적불동개선효응.방법:채용결찰좌관상동맥전강지건립AMI모형,수궤설립대조조、AMI조、LArg치료조、침자"내관"치료조、LArg가침자"내관"치료조,관찰평균동맥압(MAP)、심솔(HR)화심공능다항지표적변화.결과:AMI조이상각항지표교정상대조조명현강저,이각치료조이상각항지표균유불동정도적개선,기중침약결합치료조개선최현저.결론:LArg가침자내관연합응용대AMI유경호적치료효과.
Objective: The present study is to observe and compare the different effects of electroacupuncture(EA) at acupoint Neiguan (PC 6), intravenous administration of L-arginine(L-Arg, a precursor of nitric oxide), and the drug administration combined with the EA on acute myocardial ischemia(AMI) in rats. Methods: The rat model of AMI was established by occlusion of the anterior descending branch of the left coronary artery, then the animals were divided randomly into 5 groups,i.e. control group, AMI group, L-Arg treatment group, EA treatment group and L-Arg plus EA treatment group, the mean arterial pressure(MAP), heart rate(HR) and the cardiac functions were observed and recorded. Results: The data showed that MAP, HR and all the indices of cardiac functions in the AMI group were significantly lower than those in control group, and the indices in each treatment group were all improved to different extents, especially in L-Arg plus EA treatment group. Conclusion: The combined use of L-Arg and EA had the better therapeutic effect on the AMI.