国际肿瘤学杂志
國際腫瘤學雜誌
국제종류학잡지
JOURNAL OF INTERNATIONAL ONCOLOGY
2012年
2期
143-145
,共3页
信号传导%药理作用分子作用机制%结肠肿瘤%磷脂酰肌醇3激酶-蛋白激酶B信号通路
信號傳導%藥理作用分子作用機製%結腸腫瘤%燐脂酰肌醇3激酶-蛋白激酶B信號通路
신호전도%약리작용분자작용궤제%결장종류%린지선기순3격매-단백격매B신호통로
Signal transduction%Molecular mechanisms of pharmacological action%Colonic neoplasms%PI3K-Akt
磷脂酰肌醇3激酶-蛋白激酶B( PI3 K-Akt)信号通路异常激活已经被证实与多种肿瘤发生发展密切相关,并且PI3K-Akt通路在结肠癌的发生发展中起重要作用,它参与调控结肠肿瘤细胞存活和增殖、抑制凋亡、促进细胞周期进程等,并且通过抑制该通路还可能在结肠癌治疗中有潜在作用.
燐脂酰肌醇3激酶-蛋白激酶B( PI3 K-Akt)信號通路異常激活已經被證實與多種腫瘤髮生髮展密切相關,併且PI3K-Akt通路在結腸癌的髮生髮展中起重要作用,它參與調控結腸腫瘤細胞存活和增殖、抑製凋亡、促進細胞週期進程等,併且通過抑製該通路還可能在結腸癌治療中有潛在作用.
린지선기순3격매-단백격매B( PI3 K-Akt)신호통로이상격활이경피증실여다충종류발생발전밀절상관,병차PI3K-Akt통로재결장암적발생발전중기중요작용,타삼여조공결장종류세포존활화증식、억제조망、촉진세포주기진정등,병차통과억제해통로환가능재결장암치료중유잠재작용.
The abnormal activation of phosphatidylinositol-3-kinase (PI3K)-proiein kinase B (Akt) pathway has already been confirmed to be closely related to the origin and development of various tumors.PI3KAkt pathway plays an important role in development of colon cancer,it can regulate cell survival,proliferation,anti-apoptosis,cell cycle progression,etc.Furthermore,inhibition of this pathway may play a potential roll in oncotherapy.
