中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
z1期
9-11
,共3页
心力衰竭%坎地沙坦%综合分析
心力衰竭%坎地沙坦%綜閤分析
심력쇠갈%감지사탄%종합분석
Congestive heart failure%Chronic candesartan%Meta-analysis
目的 探讨慢性充血性心力衰竭(CCHF)坎地沙坦治疗前后心功能及内分泌激素的变化.方法 80例慢性充血性心力衰竭患者,随机分为观察组40例和对照组40例；对照组给予常规治疗,观察组在对照组治疗的基础上给予坎地沙坦酯片4 mg/d,两组疗程均为8周.结果 观察组总有效率为87.5％,明显高于对照组的70.0％(x2=3.785,P＜0.05)；两组治疗前后SBP、DBP、HR、6 min步行试验差异均有统计学意义(t=2.233、2.241、2.305、2.207,均P＜0.05)；两组治疗前后PRA、AngⅡ、ALD、BNP含量差异均有显著性差异(t=2.221、2.145、2.314、2.307,均P＜0.05)；两组治疗前后LVEDD、LVEF含量差异均有统计学意义(t=2.241、2.215,均P＜0.05).结论 坎地沙坦可以提高CHF患者疗效,改善心功能.
目的 探討慢性充血性心力衰竭(CCHF)坎地沙坦治療前後心功能及內分泌激素的變化.方法 80例慢性充血性心力衰竭患者,隨機分為觀察組40例和對照組40例；對照組給予常規治療,觀察組在對照組治療的基礎上給予坎地沙坦酯片4 mg/d,兩組療程均為8週.結果 觀察組總有效率為87.5％,明顯高于對照組的70.0％(x2=3.785,P＜0.05)；兩組治療前後SBP、DBP、HR、6 min步行試驗差異均有統計學意義(t=2.233、2.241、2.305、2.207,均P＜0.05)；兩組治療前後PRA、AngⅡ、ALD、BNP含量差異均有顯著性差異(t=2.221、2.145、2.314、2.307,均P＜0.05)；兩組治療前後LVEDD、LVEF含量差異均有統計學意義(t=2.241、2.215,均P＜0.05).結論 坎地沙坦可以提高CHF患者療效,改善心功能.
목적 탐토만성충혈성심력쇠갈(CCHF)감지사탄치료전후심공능급내분비격소적변화.방법 80례만성충혈성심력쇠갈환자,수궤분위관찰조40례화대조조40례；대조조급여상규치료,관찰조재대조조치료적기출상급여감지사탄지편4 mg/d,량조료정균위8주.결과 관찰조총유효솔위87.5％,명현고우대조조적70.0％(x2=3.785,P＜0.05)；량조치료전후SBP、DBP、HR、6 min보행시험차이균유통계학의의(t=2.233、2.241、2.305、2.207,균P＜0.05)；량조치료전후PRA、AngⅡ、ALD、BNP함량차이균유현저성차이(t=2.221、2.145、2.314、2.307,균P＜0.05)；량조치료전후LVEDD、LVEF함량차이균유통계학의의(t=2.241、2.215,균P＜0.05).결론 감지사탄가이제고CHF환자료효,개선심공능.
Objective To investigate the change of heart function and endocrine hormones in patients with chronic congestive heart failure(CCHF) by candesartan treatment.Methods 80 patients with CCHF were randomly divided into:observation group( n =40) and control group( n =40) ;control group given routine cardiac stimulant and diuretic treatment;Observation group on based in the control group given candesartan tablets 4mg/d,1 week after increasing the dose to 8 mg/d,treated for 8 weeks.Results The total effective 87.5 ％ in observation group were significantly higher than 70.0％ in control group ( x2 =3.785,P ＜ O.05 ) ; The index of SBP,DBP,HR,6min walk test before and after treatment in two groups were significantly different (t =2.233,2.241,2.305,2.207,all P ＜ 0.05) ;The index of PRA,Ang Ⅱ,ALD,B NP before and after treatment in two groups were significantly different (t =2.221,2.145,2.314,2.307,all P ＜0.05 ) ; The index of LVEDD,LVEF before and after treatment in two groups were significantly different(t =2.241,2.215,all P＜0.05).Conclusion Candesartan could increase the efficacy of CHF and improve heart function.
