CAJ | 학술논문

目的探讨正常高值血压合并空腹血糖受损患者血清转化生长因子β1( TGF-β1)水平的变化.方法选择年龄及性别相匹配的健康体检者180例.根据血压及空腹血糖水平分为3组:A组(对照组)(血压＜ 120/80 mmHg,空腹血糖＜6.1 mmol/L组)60例,B组(正常高值血压+空腹血糖＜6.1 mmol/l组)60例,C组(正常高值血压+6.1 mmol/L≤空腹血糖≤7.0 mmol/L组)60例.ELISA法测定TGF-β1水平,同时检测空腹血糖、甘油三酯、总胆固醇、低密度脂蛋白胆固醇( LDL-C)、高密度脂蛋白胆固醇(HDL-C)、尿酸、体重质量指数(BMI).结果 B组和C组TGF-β1水平明显高于对照组(t=2.07l、2.147,P＜0.05),C组TGF-β1水平高于B组但其差异无统计学意义(P＞0.05).Pearson相关分析显示TGF-β1与收缩压间呈正相关(r=0.279,P=0.047).结论正常高值血压患者血清TGF-β1水平升高,TGF-β1可能介导了正常高值血压患者的靶器官损害.
목적 탐토정상고치혈압합병공복혈당수손환자혈청전화생장인자β1( TGF-β1)수평적변화.방법 선택년령급성별상필배적건강체검자180례.근거혈압급공복혈당수평분위3조:A조(대조조)(혈압＜ 120/80 mmHg,공복혈당＜6.1 mmol/L조)60례,B조(정상고치혈압+공복혈당＜6.1 mmol/l조)60례,C조(정상고치혈압+6.1 mmol/L≤공복혈당≤7.0 mmol/L조)60례.ELISA법측정TGF-β1수평,동시검측공복혈당、감유삼지、총담고순、저밀도지단백담고순( LDL-C)、고밀도지단백담고순(HDL-C)、뇨산、체중질량지수(BMI).결과 B조화C조TGF-β1수평명현고우대조조(t=2.07l、2.147,P＜0.05),C조TGF-β1수평고우B조단기차이무통계학의의(P＞0.05).Pearson상관분석현시TGF-β1여수축압간정정상관(r=0.279,P=0.047).결론 정상고치혈압환자혈청TGF-β1수평승고,TGF-β1가능개도료정상고치혈압환자적파기관손해.
Objective To explore the level of serum transforming growth factor-β1 (TGF-β1) in patients with prehypertension and impaired fasting blood glucose.Methods A total of 180 healthy subjects with matched age and sex was divided into 3 groups:group A (blood pressure ＜ 120/80 mmHg and fasting blood glucose ＜6.1 mmoVL),group B (prehypertension and fasting blood glucose ＜6.1 mmol/L),group C (prehypertension and 6.1 mmol/L≤ fasting blood glucose ≤7.0 mmol/L).There were 60 subjects in every group.Serum TGF-β1 was measured by Enzyme-Linked Immunosobent Assay (ELISA),fasting blood glucose,triglyceride,total cholesterol,low-density lipoprotein cholesterol ( LDL-C),high-density lipoprotein cholesterol ( HDL-C),Uric Acid ( UA),body mass index (BMI) were determined.Results The level of serum TGF-β1 in group B and C was higher in that in group A( t =2.071,and 2.147,P ＜0.05 ).The level of serum TGF-β1 was higher in group C than group B,but no significant difference was observed ( P ＞0.05).The pearson correlation analysis showed there was a significant correlation between TGF-β1 and systolic blood pressure ( r =0.279,P =0.047).Conclusions The level of serum TGF-β1 was higher in patients with prehypertention which may mediate the target organ damage caused by the prehypertention.