CAJ | 학술논문

目的了解联合食管多通道腔内阻抗pH(MII-pH)监测诊断胃食管反流病(GERD)的价值.方法纳入具有烧心症状且食管黏膜无损伤患者44例,首先行MII-pH监测,然后行14 d的雷贝拉唑试验(试验结束时烧心症状完全消失定义为雷贝拉唑试验阳性).70名健康志愿者行MII-pH监测的结果作为正常值进行参照.结果根据食管pH监测存在异常食管酸暴露或酸反流症状指数(SI)阳性者20例(45.4%).MII-pH监测提示弱酸反流SI阳性者2例,据此检查诊断烧心患者GERD的比例增至50%(22/44).雷贝拉唑试验阳性4例,据此则将烧心患者诊断为GERD的比例增至54.5%(24/44).结论联合食管MII-pH监测可增加GERD检出率.
목적 료해연합식관다통도강내조항pH(MII-pH)감측진단위식관반류병(GERD)적개치.방법 납입구유소심증상차식관점막무손상환자44례,수선행MII-pH감측,연후행14 d적뢰패랍서시험(시험결속시소심증상완전소실정의위뢰패랍서시험양성).70명건강지원자행MII-pH감측적결과작위정상치진행삼조.결과 근거식관pH감측존재이상식관산폭로혹산반류증상지수(SI)양성자20례(45.4%).MII-pH감측제시약산반류SI양성자2례,거차검사진단소심환자GERD적비례증지50%(22/44).뢰패랍서시험양성4례,거차칙장소심환자진단위GERD적비례증지54.5%(24/44).결론 연합식관MII-pH감측가증가GERD검출솔.
Objective To investigate the role of combined multichannel intralumminal impedanee-pH (MII-pH) monitoring in the diagnosis of gastroesophageal reflux disease (GERD). Methods Forty-four consecutive patients, who had heartburn symptom and without esophageal mucosal lesion, underwent combined MII-pH monitoring. Then rabeprazole test was performed for 14 days with 10 mg twice daily. Rabeprazole test was defined as positive if patients were totally heartburn symptom free in the second week. The normal values from 70 healthy volunteers who underwent MII-pH monitoring were served as controls. Results Conventional esophageal pH monitoring showed that 20 patients (45.5%) had pathologic esophageal acid exposure or positive acid reflux associated symptom index. MII-pH monitoring revealed that 2 patients were positive for weakly acidic reflux related to symptom index, thus increased the diagnostic yield to 50% (22/44). Furthermore, rabeprazole test demonstrated that 4 patients were positive which increased the diagnostic yield to 54.5%(24/44). Conclusion The detective rate of GERD will be elevated if combined with MII-pH monitoring in diagnosis.