中华肿瘤杂志
中華腫瘤雜誌
중화종류잡지
CHINESE JOURNAL OF ONCOLOGY
2009年
11期
841-844
,共4页
任刚%于国%刘丽威%马林
任剛%于國%劉麗威%馬林
임강%우국%류려위%마림
胆囊肿瘤%上皮细胞黏附分子%细胞周期素D1%免疫组织化学%预后
膽囊腫瘤%上皮細胞黏附分子%細胞週期素D1%免疫組織化學%預後
담낭종류%상피세포점부분자%세포주기소D1%면역조직화학%예후
Gallbladder neoplasms%Ep-CAM%cychn D1%Immunohistochemistry%Prognosis
目的 探讨上皮细胞黏附分子(Ep-CAM)和细胞周期素D1(cyclin D1)蛋白在胆囊癌组织中的表达及其与患者临床病理特征及预后之间的关系.方法 采用免疫组化法检测60例胆囊癌组织及15例痛旁组织中Ep-CAM和cyclin D1蛋白的表达情况,分析Ep-CAM和cyclin D1蛋白的表达与且H囊癌患者临床病理特征以及预后的关系.结果 Ep-CAM和eyelin D1蛋白在胆囊癌组织中的阳性表达率分别为56.7%和48.3%,均明显高于癌旁组织(均P＜0.05).Ep-CAM蛋白的表达与胆囊癌患者的性别、年龄、有无结石、肿瘤的病理类型、Nevin分期、分化程度、坏死情况、神经及血管侵犯情况均无关(均P＞0.05),而cyclin D1蛋白的表达仅与肿瘤组织的分化程度及坏死情况相关(均P＜0.05).生存分析显示,Ep-CAM蛋白阳性表达组患者的中位生存时间为7个月,明显短于阴性表达组(14个月,P=0.028).cyclin D1蛋白阳性表达组患者的中位生存时间为6个月,亦明显短于阴性表达组(14个月,P=0.006).Ep-CAM与cyelin D1蛋白的表达呈正相关(r=0.307,P=0.017).结论 Ep-CAM和cyclin D1蛋白的阳性表达为胆囊癌的不良预后因素.
目的 探討上皮細胞黏附分子(Ep-CAM)和細胞週期素D1(cyclin D1)蛋白在膽囊癌組織中的錶達及其與患者臨床病理特徵及預後之間的關繫.方法 採用免疫組化法檢測60例膽囊癌組織及15例痛徬組織中Ep-CAM和cyclin D1蛋白的錶達情況,分析Ep-CAM和cyclin D1蛋白的錶達與且H囊癌患者臨床病理特徵以及預後的關繫.結果 Ep-CAM和eyelin D1蛋白在膽囊癌組織中的暘性錶達率分彆為56.7%和48.3%,均明顯高于癌徬組織(均P＜0.05).Ep-CAM蛋白的錶達與膽囊癌患者的性彆、年齡、有無結石、腫瘤的病理類型、Nevin分期、分化程度、壞死情況、神經及血管侵犯情況均無關(均P＞0.05),而cyclin D1蛋白的錶達僅與腫瘤組織的分化程度及壞死情況相關(均P＜0.05).生存分析顯示,Ep-CAM蛋白暘性錶達組患者的中位生存時間為7箇月,明顯短于陰性錶達組(14箇月,P=0.028).cyclin D1蛋白暘性錶達組患者的中位生存時間為6箇月,亦明顯短于陰性錶達組(14箇月,P=0.006).Ep-CAM與cyelin D1蛋白的錶達呈正相關(r=0.307,P=0.017).結論 Ep-CAM和cyclin D1蛋白的暘性錶達為膽囊癌的不良預後因素.
목적 탐토상피세포점부분자(Ep-CAM)화세포주기소D1(cyclin D1)단백재담낭암조직중적표체급기여환자림상병리특정급예후지간적관계.방법 채용면역조화법검측60례담낭암조직급15례통방조직중Ep-CAM화cyclin D1단백적표체정황,분석Ep-CAM화cyclin D1단백적표체여차H낭암환자림상병리특정이급예후적관계.결과 Ep-CAM화eyelin D1단백재담낭암조직중적양성표체솔분별위56.7%화48.3%,균명현고우암방조직(균P＜0.05).Ep-CAM단백적표체여담낭암환자적성별、년령、유무결석、종류적병리류형、Nevin분기、분화정도、배사정황、신경급혈관침범정황균무관(균P＞0.05),이cyclin D1단백적표체부여종류조직적분화정도급배사정황상관(균P＜0.05).생존분석현시,Ep-CAM단백양성표체조환자적중위생존시간위7개월,명현단우음성표체조(14개월,P=0.028).cyclin D1단백양성표체조환자적중위생존시간위6개월,역명현단우음성표체조(14개월,P=0.006).Ep-CAM여cyelin D1단백적표체정정상관(r=0.307,P=0.017).결론 Ep-CAM화cyclin D1단백적양성표체위담낭암적불량예후인소.
Objective To investigate the expressions of Ep-CAM and cyclin D1 and their correlation with the clinicopathological factors and prognosis in gallbladder carcinoma.Methods Ep-CAM and cyclin D1 expressions were detected by PV6000 immunohistochemical staining in 60 gallbladder carcinoma and 15 pars-cancerous mucosa specimem.Results Ep-CAM and cyclin DI expressions were detected in 56.7%and 48.3%of the cancer tissues,respectively,significantly higher than those in the normal mucosa(P＜0.05).Ep-CAM expression was not correlated with clinicopathological data,however cyclin D1 expression was correlated with pathological differentiation and necrosis(P＜0.05).Survival analysis showed that patients with positive Ep-CAM or cyclin D1 expression had a shorter survival time than that in the patients without(P＜0.05).Moreover,Ep-CAM and eyclin D1 expressions were positively correlated with each other(r=0.307.P=0.017).Conelusion Ep-CAM or eyelin DI expression is a unfavorable prognostic factor in gallbladder carcinoma.
