同济大学学报(医学版)
同濟大學學報(醫學版)
동제대학학보(의학판)
JOURNAL OF TONGJI UNIVERSITY
2001年
1期
25-27
,共3页
徐丹令%李广君%李颖%倪之挺
徐丹令%李廣君%李穎%倪之挺
서단령%리엄군%리영%예지정
脑缺血%氨基酸,兴奋性%MK*.801%形态学%大鼠
腦缺血%氨基痠,興奮性%MK*.801%形態學%大鼠
뇌결혈%안기산,흥강성%MK*.801%형태학%대서
-801能阻止EAA对脑的损伤，起保护作用。
-801能阻止EAA對腦的損傷，起保護作用。
-801능조지EAA대뇌적손상，기보호작용。
Objective The model of ischemic rats was made and MK*.801 was applied to observe the change of excitatory amino acid (EAA) and also pathological change in rat hippocampus. Methods The quantity of EAA at different ischemic time was measured by using the improving method of Pulsinelli's and the morphologic change in hippocampus after induced ischemia was studied with the application of MK*.801. Results After induced ischemia, the EAA level raised significantly by the time and MK*.801, a EAA receptor antagonist, could reduce the damage of cells in hippocampus. Conclusion EAA level increased with the degree and time of ischemia. MK*.801 can prevent the damage from EAA in ischemia.
