中国临床康复
中國臨床康複
중국림상강복
CHINESE JOURNAL OF CLINICAL REHABILITATION
2005年
18期
256-257
,共2页
雷季良%赵靖%杨立元%王珂%裴群羽
雷季良%趙靖%楊立元%王珂%裴群羽
뢰계량%조정%양립원%왕가%배군우
周围神经/损伤%物理疗法%神经再生
週圍神經/損傷%物理療法%神經再生
주위신경/손상%물리요법%신경재생
背景:周围神经纤维再生环境的改变,可以促进神经纤维的再生速度,加速神经功能的恢复.物理疗法可改善损伤部位局部微循环的流速,增进和刺激创伤的恢复进程,因此,对不同物理疗法的选择和照射剂量的控制,可否促进神经纤维再生速度?目的:观察不同物理方法照射对大鼠受损神经纤维再生的促进作用.设计:随机分组对照的动物实验.单位:北京大学医学部人体解剖学与组织胚胎学系实验室.对象:实验于2001-09/2002-09在北京大学医学部人体解剖学与组织胚胎学系实验室完成,雄性SD大鼠15只,体质量185～220 g.干预:建立大鼠坐骨神经损伤模型后,随机分为3组.生物频谱组5只,红外线照射组5只,分别给予相应的物理照射.损伤对照组5只不做照射.3组动物分别在手术后第14天,取手术侧坐骨神经段切片,以光镜下观察受损神经纤维溃变率的减少间接了解物理疗法对神经受损后的保护功能.主要观察指标:神经断裂处及靠近脊髓侧4点(1,2,3,4 mm)和远离脊髓侧4点(1,2,3,4 mm)受损处神经纤维的溃变率.结果:15只大鼠均进入结果分析.①生物频谱组和红外线照射组的坐骨神经纤维与对照组在断裂处的远离脊髓侧神经纤维溃变率无差异(均为100%).②在断裂处生物频谱组和红外线组的神经纤维溃变率明显降低(68%,89%),对照组最高(100%).③3组靠近脊髓侧4点神经纤维溃变率呈递减趋势,即越靠近脊髓侧溃变率越低;并且生物频谱组最低,红外线组次之,对照组最高.结论:受损周围神经修复后,选用物理疗法辅助治疗可使溃变的神经纤维数量减少,有促进和加快神经纤维恢复的作用,其中生物频谱照射法效果更好些.
揹景:週圍神經纖維再生環境的改變,可以促進神經纖維的再生速度,加速神經功能的恢複.物理療法可改善損傷部位跼部微循環的流速,增進和刺激創傷的恢複進程,因此,對不同物理療法的選擇和照射劑量的控製,可否促進神經纖維再生速度?目的:觀察不同物理方法照射對大鼠受損神經纖維再生的促進作用.設計:隨機分組對照的動物實驗.單位:北京大學醫學部人體解剖學與組織胚胎學繫實驗室.對象:實驗于2001-09/2002-09在北京大學醫學部人體解剖學與組織胚胎學繫實驗室完成,雄性SD大鼠15隻,體質量185～220 g.榦預:建立大鼠坐骨神經損傷模型後,隨機分為3組.生物頻譜組5隻,紅外線照射組5隻,分彆給予相應的物理照射.損傷對照組5隻不做照射.3組動物分彆在手術後第14天,取手術側坐骨神經段切片,以光鏡下觀察受損神經纖維潰變率的減少間接瞭解物理療法對神經受損後的保護功能.主要觀察指標:神經斷裂處及靠近脊髓側4點(1,2,3,4 mm)和遠離脊髓側4點(1,2,3,4 mm)受損處神經纖維的潰變率.結果:15隻大鼠均進入結果分析.①生物頻譜組和紅外線照射組的坐骨神經纖維與對照組在斷裂處的遠離脊髓側神經纖維潰變率無差異(均為100%).②在斷裂處生物頻譜組和紅外線組的神經纖維潰變率明顯降低(68%,89%),對照組最高(100%).③3組靠近脊髓側4點神經纖維潰變率呈遞減趨勢,即越靠近脊髓側潰變率越低;併且生物頻譜組最低,紅外線組次之,對照組最高.結論:受損週圍神經脩複後,選用物理療法輔助治療可使潰變的神經纖維數量減少,有促進和加快神經纖維恢複的作用,其中生物頻譜照射法效果更好些.
배경:주위신경섬유재생배경적개변,가이촉진신경섬유적재생속도,가속신경공능적회복.물리요법가개선손상부위국부미순배적류속,증진화자격창상적회복진정,인차,대불동물리요법적선택화조사제량적공제,가부촉진신경섬유재생속도?목적:관찰불동물리방법조사대대서수손신경섬유재생적촉진작용.설계:수궤분조대조적동물실험.단위:북경대학의학부인체해부학여조직배태학계실험실.대상:실험우2001-09/2002-09재북경대학의학부인체해부학여조직배태학계실험실완성,웅성SD대서15지,체질량185～220 g.간예:건립대서좌골신경손상모형후,수궤분위3조.생물빈보조5지,홍외선조사조5지,분별급여상응적물리조사.손상대조조5지불주조사.3조동물분별재수술후제14천,취수술측좌골신경단절편,이광경하관찰수손신경섬유궤변솔적감소간접료해물리요법대신경수손후적보호공능.주요관찰지표:신경단렬처급고근척수측4점(1,2,3,4 mm)화원리척수측4점(1,2,3,4 mm)수손처신경섬유적궤변솔.결과:15지대서균진입결과분석.①생물빈보조화홍외선조사조적좌골신경섬유여대조조재단렬처적원리척수측신경섬유궤변솔무차이(균위100%).②재단렬처생물빈보조화홍외선조적신경섬유궤변솔명현강저(68%,89%),대조조최고(100%).③3조고근척수측4점신경섬유궤변솔정체감추세,즉월고근척수측궤변솔월저;병차생물빈보조최저,홍외선조차지,대조조최고.결론:수손주위신경수복후,선용물리요법보조치료가사궤변적신경섬유수량감소,유촉진화가쾌신경섬유회복적작용,기중생물빈보조사법효과경호사.
BACKGROUND: The environmental change of regeneration of peripheral nerve fiber can accelerate the regeneration of nerve fiber and the recovery of nerve function. Physiotherapy can improve the local microcirculation of the injured area, and promote and stimulate the recovery course of trauma. Therefore, whether choosing different physiotherapies and controlling irradiation dose can speed up the regeneration of nerve fiber?OBJECTIVE: To observe the effects of different physiotherapies in promoting the regeneration of injured nerve fiber.DESIGN:Randomized grouping and controlled animal experiment.SETTING: Laboratory of Anthropotomy and Histo-Embryology Department,Peking University Health Science Center.MATERIALS: The experiment was conducted in the Laboratory of Anthropotomy and Histo-Embryology Department, Peking University Health Science Center, from September 2001 to September 2002. Fifteen adult male SD rats, weighting 185-220 g, were selected.INTERVENTIONS: The model of sciatic nerve injury was established and randomly assigned to 3 groups. Bio-spectrum group and infrared group with 5rats in each received the corresponding physical irradiation. Injury control group was given no irradiation. The slices of sciatic nerve at the operation side of the animals in the three groups were collected on day 14 after operation. The degeneration rate of the injured nerve fiber was observed under the optical microscope to make indirect assessment of the protective effect of physiotherapy after the nerve was injured.MAIN OUTCOME MEASURES: The degeneration rate of nerve fibers at the breakpoint and at 4 points near the spinal cord ( 1,2,3,4 mm) and away from the spinal cord( 1,2,3,4 mm).difference in the degeneration rate of nerve fibers at the breakpoint away from the spinal cord in bio-spectrum group and infrared group as compared with the degeneration rate of nerve fibers in bio-spectrum group(68% ) and infrared group(89% ) was obviously reduced and that in control group was the the spinal cord in the 3 groups showed decreasing trend: the closer to the spinal cord, the fewer the degenerative nerve fibers. The number of degenerative nerve fibers was the smallest in bio-spectrum group, second smallest in infrared group, and the largest in control group.CONCLUSION: The assisting physiotherapy can decrease the number of regenerative nerve fibers, thus promoting and accelerating their recovery. Irradiation with bio-spectrum equipment is more effective.
