中国骨质疏松杂志
中國骨質疏鬆雜誌
중국골질소송잡지
CHINESE JOURNAL OF OSTEOPOROSIS
2009年
11期
849-852
,共4页
Cbfa1%骨质疏松%成骨细胞%破骨细胞
Cbfa1%骨質疏鬆%成骨細胞%破骨細胞
Cbfa1%골질소송%성골세포%파골세포
Cbfa1%Osteoporosis%Osteoblast%Osteoclast
骨的形成与吸收是一个涉及众多的基因和生长因子的复杂过程,凡可使骨形成下降和骨吸收增加的因素都会促进骨质疏松的发生.Cbfa1是成骨细胞分化和成熟的特异性转录因子,研究发现Cbfa1可通过促进骨形成和抑制骨吸收,对骨质疏松的发生、发展起到抑制作用,因此,我们期望随着Cbfa1基因研究的深入将为防治骨质疏松提供新思路.
骨的形成與吸收是一箇涉及衆多的基因和生長因子的複雜過程,凡可使骨形成下降和骨吸收增加的因素都會促進骨質疏鬆的髮生.Cbfa1是成骨細胞分化和成熟的特異性轉錄因子,研究髮現Cbfa1可通過促進骨形成和抑製骨吸收,對骨質疏鬆的髮生、髮展起到抑製作用,因此,我們期望隨著Cbfa1基因研究的深入將為防治骨質疏鬆提供新思路.
골적형성여흡수시일개섭급음다적기인화생장인자적복잡과정,범가사골형성하강화골흡수증가적인소도회촉진골질소송적발생.Cbfa1시성골세포분화화성숙적특이성전록인자,연구발현Cbfa1가통과촉진골형성화억제골흡수,대골질소송적발생、발전기도억제작용,인차,아문기망수착Cbfa1기인연구적심입장위방치골질소송제공신사로.
Bone formation and absorption is a complicated process involved in numerous genes and growth factors, those factors which could reduce bone formation and increase of bone absorption would promote osteoporosis. Cbfa1 is a specific transcription factor of osteobalst differentiation and maturation, study shows it has effects both on bone formation and resorption, which can inhibit osteoporosis'occurrence and development. With the deepening of the research of Cbfa1, we would find a new idea for preventing and treating osteoporosis.
