中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2012年
2期
135-137
,共3页
慢性阻塞性肺疾病%C反应蛋白%肺功能
慢性阻塞性肺疾病%C反應蛋白%肺功能
만성조새성폐질병%C반응단백%폐공능
Chronic obstructive pulmonary disease%C-reactive protein%Lung function
目的 探讨慢性阻塞性肺疾病(COPD)患者不同分期及不同分级血中C反应蛋白(CRP)浓度变化的临床意义,肺功能损害程度与CRP浓度变化的关系.方法 选择COPD急性加重期患者42例,入院时及经治疗病情好转进入缓解期出院前均进行肺功能第1秒用力呼气容量(FEV1)和1秒率(FEV1/FVC)测定；动脉血气分析:包括氧分压(PaO2)、二氧化碳分压(PaCO2)的测定；采集患者清晨空腹静脉血,采用ELISA法检测CRP浓度.同时,选择10名健康者作为对照组进行CRP测定.结果 急性加重期COPD患者血清CRP浓度较健康对照者明显增高[(6.283 ±3.168)mg/L与(0.134±0.040)mg/L,t=4.12,(P＜0.05)],COPD急性加重期Ⅳ级患者增高最明显,但各级之间差异无统计学意义(P＞0.05).COPD患者急性加重期比缓解期明显升高,差异有统计学意义[(6.283±3.168)mg/L与(4.104±1.013)mg/L;t =4.35,P＜0.05].COPD患者肺功能FEV1变化与血CRP浓度变化呈负相关(r=-0.618,P＜0.05),FEV1/FVC变化与血CRP浓度变化呈负相关(r=-0.629,P＜0.05).PaO2与血CRP浓度变化呈负相关(r=-0.605,P＜0.05),PaCO2与血CRP浓度变化呈正相关(r=0.613,P＜0.05).结论 CRP浓度的增高可能与呼吸困难程度及肺功能损害程度有关,但是CRP作为COPD患者病情进展和预后的独立指标还有待进一步研究.
目的 探討慢性阻塞性肺疾病(COPD)患者不同分期及不同分級血中C反應蛋白(CRP)濃度變化的臨床意義,肺功能損害程度與CRP濃度變化的關繫.方法 選擇COPD急性加重期患者42例,入院時及經治療病情好轉進入緩解期齣院前均進行肺功能第1秒用力呼氣容量(FEV1)和1秒率(FEV1/FVC)測定；動脈血氣分析:包括氧分壓(PaO2)、二氧化碳分壓(PaCO2)的測定；採集患者清晨空腹靜脈血,採用ELISA法檢測CRP濃度.同時,選擇10名健康者作為對照組進行CRP測定.結果 急性加重期COPD患者血清CRP濃度較健康對照者明顯增高[(6.283 ±3.168)mg/L與(0.134±0.040)mg/L,t=4.12,(P＜0.05)],COPD急性加重期Ⅳ級患者增高最明顯,但各級之間差異無統計學意義(P＞0.05).COPD患者急性加重期比緩解期明顯升高,差異有統計學意義[(6.283±3.168)mg/L與(4.104±1.013)mg/L;t =4.35,P＜0.05].COPD患者肺功能FEV1變化與血CRP濃度變化呈負相關(r=-0.618,P＜0.05),FEV1/FVC變化與血CRP濃度變化呈負相關(r=-0.629,P＜0.05).PaO2與血CRP濃度變化呈負相關(r=-0.605,P＜0.05),PaCO2與血CRP濃度變化呈正相關(r=0.613,P＜0.05).結論 CRP濃度的增高可能與呼吸睏難程度及肺功能損害程度有關,但是CRP作為COPD患者病情進展和預後的獨立指標還有待進一步研究.
목적 탐토만성조새성폐질병(COPD)환자불동분기급불동분급혈중C반응단백(CRP)농도변화적림상의의,폐공능손해정도여CRP농도변화적관계.방법 선택COPD급성가중기환자42례,입원시급경치료병정호전진입완해기출원전균진행폐공능제1초용력호기용량(FEV1)화1초솔(FEV1/FVC)측정；동맥혈기분석:포괄양분압(PaO2)、이양화탄분압(PaCO2)적측정；채집환자청신공복정맥혈,채용ELISA법검측CRP농도.동시,선택10명건강자작위대조조진행CRP측정.결과 급성가중기COPD환자혈청CRP농도교건강대조자명현증고[(6.283 ±3.168)mg/L여(0.134±0.040)mg/L,t=4.12,(P＜0.05)],COPD급성가중기Ⅳ급환자증고최명현,단각급지간차이무통계학의의(P＞0.05).COPD환자급성가중기비완해기명현승고,차이유통계학의의[(6.283±3.168)mg/L여(4.104±1.013)mg/L;t =4.35,P＜0.05].COPD환자폐공능FEV1변화여혈CRP농도변화정부상관(r=-0.618,P＜0.05),FEV1/FVC변화여혈CRP농도변화정부상관(r=-0.629,P＜0.05).PaO2여혈CRP농도변화정부상관(r=-0.605,P＜0.05),PaCO2여혈CRP농도변화정정상관(r=0.613,P＜0.05).결론 CRP농도적증고가능여호흡곤난정도급폐공능손해정도유관,단시CRP작위COPD환자병정진전화예후적독립지표환유대진일보연구.
Objective To study the significance of changes in the blood C-reactive protein(CRP)concentration in patients with chronic obstructive pulmonary disease(COPD)at different stages and different classification and further analyze the relationship between the degree of impairment of pulmonary function and CRP concentrations.Methods Fouty-two cases of COPD patients were enrolled,forced expiratory volume in one second(FEV1),the forced expiratory volume in one second/forced vital capacity(FEV1/FVC),a second rate were tested in these patients at admission and discharged from hospital after recovery.Arterial blood gas including PaO2,PaCO2 were analyzed.The CRP level was measured by ELISA from venous blood collected in the early morning.At the same time,10 healthy people were selected as control group.Results The CRP level in COPD group was significantly higher than that of the control group(P ＜ 0.05).It displayed highest in the Ⅳ grade of COPD patients,but there was no statistically significant differences among the levels(P ＞ 0.05).The CRP level in COPD patients at acute exacerbations was significantly higher than that in COPD patients at remission and differences was statistically significant([6.283 ± 3.168]mg/L vs[4.104 ± 1.013]mg/L,P ＜0.05).The changes of serum CRP levels was correlated negatively with FEV1(r =-0.618,P ＜ 0.05),with FEV1/FVC(r =-0.629,P ＜ 0.05)and with PaO2(r =-0.605,P ＜ 0.05).The changes of serum CRP levels was correlated positively with PaCO2(r =0.613,P ＜ 0.05).Conclusion The increase of CRP level may be associated with the damage of lung function and the degree of dyspnea in COPD patients.But CRP as a independent predictor of COPD outcomes and prognosis remains to be further studied.
