CAJ | 학술논문

目的观察半量维替泊芬光动力疗法(PDT)治疗黄斑区中心性浆液性脉络膜视网膜病变(中浆)的疗效.方法经临床眼底镜检查、眼底荧光血管造影(FFA)及光学相干断层成像(OCT)检查确诊为黄斑区的中浆患者15例15只眼,采用半量PDT进行治疗,维替泊芬注射15 min后689 nm激光进行照射83 s.治疗后随访1～12月,平均4.5月,术后行视力、眼底、FFA及OCT检查.结果最佳矫正视力0.4～1.2,平均0.78,视力明显改善者14只眼,视力稳定者1只眼,FFA检查显示渗漏完全消失者13只眼,部分消失者2只眼.治疗后1、3月OCT检查显示黄斑厚度恢复正常14只眼,部分吸收1只眼；眼底检查显示黄斑水肿基本消失,未见病情恶化者,半年后1只眼复发.结论半量PDT是治疗黄斑中心区中浆的有效方法,病程越短显效越快,黄斑OCT可以很好显示治疗效果,但是尚需要进一步的对照研究来观察其长期安全性和有效性.
목적 관찰반량유체박분광동력요법(PDT)치료황반구중심성장액성맥락막시망막병변(중장)적료효.방법 경림상안저경검사、안저형광혈관조영(FFA)급광학상간단층성상(OCT)검사학진위황반구적중장환자15례15지안,채용반량PDT진행치료,유체박분주사15 min후689 nm격광진행조사83 s.치료후수방1～12월,평균4.5월,술후행시력、안저、FFA급OCT검사.결과 최가교정시력0.4～1.2,평균0.78,시력명현개선자14지안,시력은정자1지안,FFA검사현시삼루완전소실자13지안,부분소실자2지안.치료후1、3월OCT검사현시황반후도회복정상14지안,부분흡수1지안；안저검사현시황반수종기본소실,미견병정악화자,반년후1지안복발.결론 반량PDT시치료황반중심구중장적유효방법,병정월단현효월쾌,황반OCT가이흔호현시치료효과,단시상수요진일보적대조연구래관찰기장기안전성화유효성.
Objective To observe the therapeutic effect of photodynamic therapy (PDT) with half dose for central serous chorioretinopathy in macular. Methods Fifteen eyes of 15 patients with CSC in macular determined by ophthalmoscope,fundus fluorescence angiography (FFA) and OCT underwent photodynamic therapy with half standard dose verteporfin.Vertepofin was infused over 15minutes by laser application 30 seconds.Postoperatively,all patients were followed up for 1-12months (mean 4.5 months).During the time of follow up,examinations included visual acuity measurement,fundus examination,FFA and OCT. Results Best corrected visual acuity (BCVA) was 0.4-1.2 (mean 0.78).The BCVA increased obviously in 14 eyes,stabilized in 1 eye.In FFA,the leakage regressed totally in 13 eyes,mostly in 2 eyes.The thickness of retinal neuro-epithelial layer of OCT recovered to normal in 14 eyes,mostly in 1 eye,while progressed in no one,1 eye CSC recurred in six months.Conclusions PDT with half standard dose verteporfin is beneficial to CSC,but further controlled study is warranted to demonstrate the safety and efficacy of long time in the therapy.