CAJ | 학술논문

目的探讨多发性骨髓瘤(MM)患者血清胆固醇水平变化及其与分型、分期的关系.方法回顾分析65例MM患者诊断时血脂水平,包括总胆固醇(TC)、三酰什油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(Apo-A1)和载脂蛋白B(Apo-B),探讨血脂参数与MM患者免疫球蛋白类型和临床分期关系.以健康体检者30例作为对照组.结果 65例MM患者中IgG型35例(53.85%),Ⅲ期41例(63.1%),MM患者血清TC、HDL-C、LDL-C、Apo-A1和Apo-B明显低于对照组(P<0.05),两组TG差异无统计学意义(P>0.05);除1例IgD型外,其余64例患者中,IsG和IgA型患者血清TC、HDL-C、LDL-C、Apo-Al和Apo-B均显著低于轻链型(P<0.05),TG水平在不同Ig类型患者间无差别;Ⅲ期患者血清TC、HDL-C、LDL-C和Apo-A1均显著低于Ⅰ期患者和对照组(P均<0.05),且Ⅱ期患者血清LDL-C也显著低于Ⅰ期患者(P<0.05).结论 MM患者存在低胆固醇血症,且血清胆固醇水平与疾病分期有关.
목적 탐토다발성골수류(MM)환자혈청담고순수평변화급기여분형、분기적관계.방법 회고분석65례MM환자진단시혈지수평,포괄총담고순(TC)、삼선십유(TG)、고밀도지단백담고순(HDL-C)、저밀도지단백담고순(LDL-C)、재지단백A1(Apo-A1)화재지단백B(Apo-B),탐토혈지삼수여MM환자면역구단백류형화림상분기관계.이건강체검자30례작위대조조.결과 65례MM환자중IgG형35례(53.85%),Ⅲ기41례(63.1%),MM환자혈청TC、HDL-C、LDL-C、Apo-A1화Apo-B명현저우대조조(P<0.05),량조TG차이무통계학의의(P>0.05);제1례IgD형외,기여64례환자중,IsG화IgA형환자혈청TC、HDL-C、LDL-C、Apo-Al화Apo-B균현저저우경련형(P<0.05),TG수평재불동Ig류형환자간무차별;Ⅲ기환자혈청TC、HDL-C、LDL-C화Apo-A1균현저저우Ⅰ기환자화대조조(P균<0.05),차Ⅱ기환자혈청LDL-C야현저저우Ⅰ기환자(P<0.05).결론 MM환자존재저담고순혈증,차혈청담고순수평여질병분기유관.
Objective To investigate the relationship between serum cholesterol levels and immunoglobin types and clinical stages in the patients with multiple myeloma (MM). Methods We retrospectively analyzed the blood lipid levels in 65 patients with MM at diagnosis, including total cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), apolipoprotein Al (apo-Al) and apolipoprotein B (apo-B), and explored relationship between lipid parameters and immunoglobulin types or clinical stages in patients with MM. Thirty healthy persons were served as controls. Results Of the 65 MM patients, 53.85% were IgG type, 63.1 % were at stage Ⅲ. The levels of TC, HDL-C, LDL-C, apo Al and apo B in the patients with MM were significantly lower than that in the controls (P <0.05), and TG in MM patients was no difference with that in the controls (P >0.05). Except one case of IgD type, the levels of TC, HDL-C, LDL-C, apo Al and apo B in Ig G and Ig A types of patients were significantly lower than that in the light chain type among other 64 cases (P <0.05), and TG levels in different immunoglobulin types was found no statistical differences. The levels of TC, HDL-C, LDL-C and apo A1 in the patients with stage Ⅲ were lower than that of stage I and controls (P <0.05), furthermore, the level of LDL in stage Ⅱwas lower than that in stage Ⅰ. Conclusion Hypocholesterolemia are seen in the patients with MM and serum cholesterol levels are related to MM staging.