CAJ | 학술논문

为了观察热缺血时间对供肺肺功能的影响.将15只杂种犬分为三组,热缺血时间分别是1、2和0小时(无热缺血的对照组).实验建立模拟左单肺原位移植(即肺门血管暂时性阻断),观测阻断后6小时内犬氧分压、二氧化碳分压、平均肺动脉压、缺血肺湿重/干重比、肺Ⅱ型细胞活性度改变.实验结果表明,尽管热缺血1小时组较无热缺血的对照组肺再灌注损伤严重,但模拟移植肺短期内仍具有较好的肺功能,肺组织损伤轻,而热缺血2小时组则肺功能差,肺组织损坏较严重.
위료관찰열결혈시간대공폐폐공능적영향.장15지잡충견분위삼조,열결혈시간분별시1、2화0소시(무열결혈적대조조).실험건립모의좌단폐원위이식(즉폐문혈관잠시성조단),관측조단후6소시내견양분압、이양화탄분압、평균폐동맥압、결혈폐습중/간중비、폐Ⅱ형세포활성도개변.실험결과표명,진관열결혈1소시조교무열결혈적대조조폐재관주손상엄중,단모의이식폐단기내잉구유교호적폐공능,폐조직손상경,이열결혈2소시조칙폐공능차,폐조직손배교엄중.
In order to observe the influence of warm ischemia time(WIT)on canine cadaver donor lungs, 15 adult dogs were divided into three groups, group A with WIT for 1 h, group B with WIT for 2 h, and group C without WIT as control group.In the experiment, a model of mimicking left allograft lung transplantation was established and then PaO2, PaCO2, average pressure of the lung artery, wet/try weight ratio of ischemic lung, and type Ⅱ cell viability were recorded within 6 h to evaluate the function of the lung grafts.The results demonstrated that the cadaver donor lungs in group A had more severe reperfusion damage than in the control group, but the function of the lung grafts was still normal.The function of lung grafts in group B was poor and the damage to the lung tissue severe.