中国综合临床
中國綜閤臨床
중국종합림상
CLINICAL MEDICINE OF CHINA
2010年
3期
248-250
,共3页
曹锐彬%陈关英%蒋兰晔%谢凯
曹銳彬%陳關英%蔣蘭曄%謝凱
조예빈%진관영%장란엽%사개
支气管肺泡灌洗液%肺周围型孤立结节%肿瘤相关物质群%癌胚抗原%肺癌
支氣管肺泡灌洗液%肺週圍型孤立結節%腫瘤相關物質群%癌胚抗原%肺癌
지기관폐포관세액%폐주위형고립결절%종류상관물질군%암배항원%폐암
Bronchoalveolar lavage fluid%Periphery solitary pulmonary nodules%Tumour specific growth factors%Carcinoembryonic antigen%Lung cancer
目的 探讨血清和支气管肺泡灌洗液(BALF)中肿瘤相关物质群(TSGF)对肺周围型孤立结节良恶性鉴别诊断的价值.方法 对211例周围型肺部孤立结节患者行血清和健、患双侧支气管肺泡灌洗液TSGF、癌胚抗原(CEA)检测并与196例非肿瘤性疾病患者进行对照.结果 恶性结节患者血清和健、患双侧支气管肺泡灌洗液CEA[分别为血清(28.73±15.61)、健侧(63.31±21.28)、患侧(85.54±26.19)μg/L]、TSGF[分别为血清(88.73±13.51)、健侧(110.73±18.64)、患侧(162.80+58.89)μg/L]均高于良性患者[CEA血清为(7.21±2.43)、健侧(12.36±6.93)、患侧(14.65±8.07)μg/L;TSGF血清为(56.31±2.43)、健侧(79.25±36.86)、患侧(86.29±37.07)μg/L]及对照组[CEA血清为(4.68±1.25)、患侧为(11.06±8.03)μg/L],恶性结节组患侧支气管肺泡灌洗液TSGF、CEA检测亦高于健侧,患侧BALF中TSGF测定对恶性诊断的敏感性、特异性和正确性分别为86.6%、100.0%和98.6%,高于CEA的70.2%、78.9%和76.5%及血清TSGF的73.1%、88.9%和85.7%.结论 支气管肺泡灌洗液及血清TSGF测定对肺周围型孤立结节的良、恶性具有重要的鉴别诊断价值,尤其健、患双侧BALF中TSGF检测对肿瘤有定位诊断作用.
目的 探討血清和支氣管肺泡灌洗液(BALF)中腫瘤相關物質群(TSGF)對肺週圍型孤立結節良噁性鑒彆診斷的價值.方法 對211例週圍型肺部孤立結節患者行血清和健、患雙側支氣管肺泡灌洗液TSGF、癌胚抗原(CEA)檢測併與196例非腫瘤性疾病患者進行對照.結果 噁性結節患者血清和健、患雙側支氣管肺泡灌洗液CEA[分彆為血清(28.73±15.61)、健側(63.31±21.28)、患側(85.54±26.19)μg/L]、TSGF[分彆為血清(88.73±13.51)、健側(110.73±18.64)、患側(162.80+58.89)μg/L]均高于良性患者[CEA血清為(7.21±2.43)、健側(12.36±6.93)、患側(14.65±8.07)μg/L;TSGF血清為(56.31±2.43)、健側(79.25±36.86)、患側(86.29±37.07)μg/L]及對照組[CEA血清為(4.68±1.25)、患側為(11.06±8.03)μg/L],噁性結節組患側支氣管肺泡灌洗液TSGF、CEA檢測亦高于健側,患側BALF中TSGF測定對噁性診斷的敏感性、特異性和正確性分彆為86.6%、100.0%和98.6%,高于CEA的70.2%、78.9%和76.5%及血清TSGF的73.1%、88.9%和85.7%.結論 支氣管肺泡灌洗液及血清TSGF測定對肺週圍型孤立結節的良、噁性具有重要的鑒彆診斷價值,尤其健、患雙側BALF中TSGF檢測對腫瘤有定位診斷作用.
목적 탐토혈청화지기관폐포관세액(BALF)중종류상관물질군(TSGF)대폐주위형고립결절량악성감별진단적개치.방법 대211례주위형폐부고립결절환자행혈청화건、환쌍측지기관폐포관세액TSGF、암배항원(CEA)검측병여196례비종류성질병환자진행대조.결과 악성결절환자혈청화건、환쌍측지기관폐포관세액CEA[분별위혈청(28.73±15.61)、건측(63.31±21.28)、환측(85.54±26.19)μg/L]、TSGF[분별위혈청(88.73±13.51)、건측(110.73±18.64)、환측(162.80+58.89)μg/L]균고우량성환자[CEA혈청위(7.21±2.43)、건측(12.36±6.93)、환측(14.65±8.07)μg/L;TSGF혈청위(56.31±2.43)、건측(79.25±36.86)、환측(86.29±37.07)μg/L]급대조조[CEA혈청위(4.68±1.25)、환측위(11.06±8.03)μg/L],악성결절조환측지기관폐포관세액TSGF、CEA검측역고우건측,환측BALF중TSGF측정대악성진단적민감성、특이성화정학성분별위86.6%、100.0%화98.6%,고우CEA적70.2%、78.9%화76.5%급혈청TSGF적73.1%、88.9%화85.7%.결론 지기관폐포관세액급혈청TSGF측정대폐주위형고립결절적량、악성구유중요적감별진단개치,우기건、환쌍측BALF중TSGF검측대종류유정위진단작용.
Objective To explore clinical value of tumor specific growth factors (TSGF) in serum and bronchoalveolar lavage fluid (BALF) on differential diagnosis of benign and malignant periphery solitary pulmonary nodules (PSPN). Methods Serum and BALF from both normal and afflicted side were collected from 211 patients with PSPN(case group) and from 196 patients without any type of tumor (control group). TSGF and carcinoembry-onic antigen (CEA) in serum and BALF were measured in both groups. Results In the malignant PSPN patients, CEA in serum, normal and afflicted side were 28.73 (SD: 15.61) μg/L,63.31 (SD:21.28) μg/L and 85.54(SD: 26.19)μg/L,respectively, which was significantly higher than that of the benign PSPN patients (7.21(SD:2.43) μg/L, 12.36(SD:6.93)μg/L and 14.65 (SD:8.07)μg/L,respectively), as well as that of the control group (4.68 (SD: 1.25) μ/L and 11.06(SD:8.03) μg/L in serum and BALF, respectively (P < 0.05). TSGF in the serum and BALF from the normal and afflicted side of malignant PSPN patients was 88.73 (SD:13.51)μg/L, 110.73 (SD: 18.64) μg/L and 162.80(SD:58.89) μg/L, respectively, which were significantly higher than that of the benign PSPN patients (56.31(SD: 2.43) μg/L, 79.25 [SD: 36.86] and 86.29 (SD: 37.07) μg/L, respectively) (P <0.05). Furthermore, in the malignant PSPN patients, TSGF and CEA in the afflicted side were significantly higher than that of the normal side. Sensitivity, specificity and accuracy of TSGF in BALF from the afflicted side for malig-nant diagnosis were 86.6%,100.0% and 98.6%,respectively,which was higher than that of CEA (70.2% ,78. 9% and 76.5% respectively) and that of serum TSGF (73.1% ,88.9% and 85.7% respectively). Conclusions TSGF in bronchoalveolar lavage fluid and serum has a significant role in differential diagnosis of benign and malig-nant periphery solitary pulmonary nodules. Furthermore, measurement of TSGF in bilateral BALF is helpful in diag-nosis of tumor location.
