CAJ | 학술논문

目的探讨神经生长因子(NGF)在糖尿病性周围神经病变(DNP)发病机制中的作用及其与感觉神经传导速度(SNCV)的相关性. 方法 41名临床确诊为DNP的患者、35名患糖尿病但无DNP的患者及33名健康对照者应用酶联免疫吸附法测量血清NGF水平及左侧正中神经、尺神经、腓神经和胫神经SNCV,进行相关分析. 结果 DNP组患者血清NGF水平为(665.18±188.32)ng/L,显著低于健康对照组(976.44±159.07)ng/L和糖尿病不伴DNP组(943.32±167.33)ng/L(F=9.316,P<0.001),DNP患者NGF水平与正中神经和腓神经SNCV之间呈正相关(r=0.810,0.760,均P<0.001),NGF水平下降程度与DNP病程之间呈正相关(r=0.542,P<0.001). 结论 DNP患者血清NGF水平低于健康者,NGF合成下降在DNP的发病机制中起一定的作用.
목적 탐토신경생장인자(NGF)재당뇨병성주위신경병변(DNP)발병궤제중적작용급기여감각신경전도속도(SNCV)적상관성. 방법 41명림상학진위DNP적환자、35명환당뇨병단무DNP적환자급33명건강대조자응용매련면역흡부법측량혈청NGF수평급좌측정중신경、척신경、비신경화경신경SNCV,진행상관분석. 결과 DNP조환자혈청NGF수평위(665.18±188.32)ng/L,현저저우건강대조조(976.44±159.07)ng/L화당뇨병불반DNP조(943.32±167.33)ng/L(F=9.316,P<0.001),DNP환자NGF수평여정중신경화비신경SNCV지간정정상관(r=0.810,0.760,균P<0.001),NGF수평하강정도여DNP병정지간정정상관(r=0.542,P<0.001). 결론 DNP환자혈청NGF수평저우건강자,NGF합성하강재DNP적발병궤제중기일정적작용.
Objective To investigate the role of nerve growth factor (NGF) in the pathogenesis of diabetic neuropathy (DNP) and the correlation of NGF level with,sensory nerve conduction velocity (SNCV) and duration of DNP. Methods The 41 patients with DNP,35 diabetics without DNP and 33 healthy controls were enrolled.And the serum level of NGF was measured with ELISA,the SNCV of left medial nerve,ulnar nerve,peroneal nerve and tibial nerve were measured too. Then the correlation analysis was completed. Results The serum level of NGF was significantly lower in DNP patients [(665.18±188.32) ng/L] than in healthy controls [(976.44±159.07)ng/L] and in diabetics without DNP [(943.32±167.33) ng/L,F=9.316,P<0.001].The NGF level of DNP patients was positively correlated with SNCV of left medial nerve (r=0.810,P<0.001 ),left peroneal nerve (r=0.760,P<0.001) and duration of DNP (r=0.542,P<0.001).Conclusions The serum level of NGF is lower in DNP patients than in healthy controls.The decrease of the production of NGF may play a role in the pathogenesis of DNP.