CAJ | 학술논문

目的观察HBsAg阳性产妇所生新生儿血清乙型肝炎标志物及HBV DNA的表达.方法对282例HBsAg阳性产妇所生283例(一例双胞胎)新生儿进行乙型肝炎病毒血清免疫标志物(五项)和血清HBV DNA检测.结果 283例新生儿乙型肝炎血清标志物表现为12种模式,以HBeAg、抗HBc阳性组合最多占48.41％(137/283),其次为抗HBe、抗HBc阳性组合占22.26％(62/283),HBsAg、HBeAg、抗HBc阳性组合占12.37％(35/283),含HBsAg阳性的有5种组合占16.61％(47/283),未见五项全阴和单抗- HBs阳性者.血清HBV DNA≥1×103IU/mL者5例占1.77％.结论 HBsAg阳性产妇所生新生儿血清乙型肝炎标志物表现复杂,以HBeAg、抗HBc阳性组合为主.血清HBV DNA≥1×103IU/mL不多见.
목적 관찰HBsAg양성산부소생신생인혈청을형간염표지물급HBV DNA적표체.방법 대282례HBsAg양성산부소생283례(일례쌍포태)신생인진행을형간염병독혈청면역표지물(오항)화혈청HBV DNA검측.결과 283례신생인을형간염혈청표지물표현위12충모식,이HBeAg、항HBc양성조합최다점48.41％(137/283),기차위항HBe、항HBc양성조합점22.26％(62/283),HBsAg、HBeAg、항HBc양성조합점12.37％(35/283),함HBsAg양성적유5충조합점16.61％(47/283),미견오항전음화단항- HBs양성자.혈청HBV DNA≥1×103IU/mL자5례점1.77％.결론 HBsAg양성산부소생신생인혈청을형간염표지물표현복잡,이HBeAg、항HBc양성조합위주.혈청HBV DNA≥1×103IU/mL불다견.
Objective To observe the HBV serum markers and HBV DNA expressions of the neonates born to the HBsAg-positive mothers.Methods By detecting serum immunity markers of hepatitis B virus (5 items) and serum HBV DNA of 283 neonates (a pair of twins) born to 282 HBsAg-positive mothers.Results 12 patterns emerge from the study of the hepatitis B serum markers of 283 neonates.Topping the list is the combination of HBeAg and anti-HBc positive accounting for 48.41％ (137/283),followed by the combination of anti-Hbe and anti-HBc positive accounting for 22.26％ ( 62/283 ).The third highest combination is that of HBsAg,HBeAg and anti-HBc positive accounting for 12.37％ (35/283).There are five combinations accounting for 16.61％ (47/283),each with HBsAg-positive.No case is found of the five items all negative or only HBsAb positive.Five cases are detected of serum HBV DNA ≥ 1 ×103IU/ml accounting for 1.77％.Conclusions Neonates born to HBsAg-positive mothers display complex patterns of serum hepatitis B markers,the dominant pattern being the combination of HBeAg and anti-HBc positive.Cases of serum HBV DNA ≥ 1 × 103IU/ml are rare.