中华眼底病杂志
中華眼底病雜誌
중화안저병잡지
CHINESE JOURNAL OF OCULAR FUNDUS DISEASES
2011年
3期
222-225
,共4页
王凡%武志峰%管怀进%魏云玉%卢百阳%张洁
王凡%武誌峰%管懷進%魏雲玉%盧百暘%張潔
왕범%무지봉%관부진%위운옥%로백양%장길
糖尿病视网膜病变/病理生理学%内皮,血管%造血干细胞%糖尿病,2型/并发症
糖尿病視網膜病變/病理生理學%內皮,血管%造血榦細胞%糖尿病,2型/併髮癥
당뇨병시망막병변/병리생이학%내피,혈관%조혈간세포%당뇨병,2형/병발증
Diabetic retinopathy/pathophysiology%Endothelium,vascular%Myeloid progenitor cells%Diabetes mellitus,type 2/complications
目的 观察2型糖尿病患者糖尿病视网膜病变(DR)不同时期外周血内皮祖细胞(EPCs)的数量变化.方法 临床确诊为2型糖尿病的60例患者纳入研究.根据眼底及荧光素眼底血管造影(FFA)检查结果,将患者分为无视网膜病变(NDR)组、非增生型DR(NPDR)组及增生型DR(PDR)组,每组各20例.选择同期门诊体检正常者20名作为对照组.抽取所有受检者晨起空腹静脉血6 ml,采用流式细胞仪检测,并比较4组受检者外周血EPCs数量的变化情况.结果 对照组、NDR、NPDR及PDR组受检者外周血EPCs数量分别为(0.0179±0.0047)%、(0.0151±0.0086)%、(0.0123±0.1137)%、(0.0316±0.0294)%;PDR组受检者外周血EPCs数量较其他3组高,差异有统计学意义(x2=43.780,P＜0.05);NDR、NPDR组受检者外周血EPCs数量略低于对照组,差异无统计学意义(x2=5.244,P=0.73);NPDR组受检者外周血EPCs数量低于NDR组,但差异也无统计学意义(x2=6.016,P=0.12).结论 NDR、NPDR患者外周血EPCs数量降低,PDR患者外周血EPCs数量显著增高.
目的 觀察2型糖尿病患者糖尿病視網膜病變(DR)不同時期外週血內皮祖細胞(EPCs)的數量變化.方法 臨床確診為2型糖尿病的60例患者納入研究.根據眼底及熒光素眼底血管造影(FFA)檢查結果,將患者分為無視網膜病變(NDR)組、非增生型DR(NPDR)組及增生型DR(PDR)組,每組各20例.選擇同期門診體檢正常者20名作為對照組.抽取所有受檢者晨起空腹靜脈血6 ml,採用流式細胞儀檢測,併比較4組受檢者外週血EPCs數量的變化情況.結果 對照組、NDR、NPDR及PDR組受檢者外週血EPCs數量分彆為(0.0179±0.0047)%、(0.0151±0.0086)%、(0.0123±0.1137)%、(0.0316±0.0294)%;PDR組受檢者外週血EPCs數量較其他3組高,差異有統計學意義(x2=43.780,P＜0.05);NDR、NPDR組受檢者外週血EPCs數量略低于對照組,差異無統計學意義(x2=5.244,P=0.73);NPDR組受檢者外週血EPCs數量低于NDR組,但差異也無統計學意義(x2=6.016,P=0.12).結論 NDR、NPDR患者外週血EPCs數量降低,PDR患者外週血EPCs數量顯著增高.
목적 관찰2형당뇨병환자당뇨병시망막병변(DR)불동시기외주혈내피조세포(EPCs)적수량변화.방법 림상학진위2형당뇨병적60례환자납입연구.근거안저급형광소안저혈관조영(FFA)검사결과,장환자분위무시망막병변(NDR)조、비증생형DR(NPDR)조급증생형DR(PDR)조,매조각20례.선택동기문진체검정상자20명작위대조조.추취소유수검자신기공복정맥혈6 ml,채용류식세포의검측,병비교4조수검자외주혈EPCs수량적변화정황.결과 대조조、NDR、NPDR급PDR조수검자외주혈EPCs수량분별위(0.0179±0.0047)%、(0.0151±0.0086)%、(0.0123±0.1137)%、(0.0316±0.0294)%;PDR조수검자외주혈EPCs수량교기타3조고,차이유통계학의의(x2=43.780,P＜0.05);NDR、NPDR조수검자외주혈EPCs수량략저우대조조,차이무통계학의의(x2=5.244,P=0.73);NPDR조수검자외주혈EPCs수량저우NDR조,단차이야무통계학의의(x2=6.016,P=0.12).결론 NDR、NPDR환자외주혈EPCs수량강저,PDR환자외주혈EPCs수량현저증고.
Objective To observe the amount of endothelial progenitor cells(EPCs)at different stages of diabetic retinopathy(DR)in patients with type 2 diabetes mellitus(DM).Methods Sixty patients with type 2 DM were divided into no DR(NDR)group,non-proliferative DR(NPDR)group and proliferative DR(PDR)group according to the examination of fundus and fundus fluorescein angiography,20patients in each group.Twenty healthy people were collected as the control group.6 ml blood samples were taken from all the subjects,and then the EPCs contents in peripheral blood were detected by flow cytometry.Results The EPCs contents in peripheral blood of the control,NDR,NPDR and PDR group were(0.0179±0.0047)% ,(0.0151±0.0086)% ,(0.0123±0.1137)% ,(0.0316±0.0294)% .The EPCs contents in peripheral blood of the PDR group was significantly higher than those in others(χ2=43.780,P＜0.05);the EPCs contents in peripheral blood of the NDR and NPDR group were slightly lower than that in the control group(χ2=5.244,P=0.73);the EPCs contents in peripheral blood of the NPDR group was lower than that in the NDR group(χ2=6.0 1 6,P=0.12).Conclusion The EPCs contents in peripheral blood decreases in NDR,NPDR patients,while significantly increases in PDR patients.
