CAJ | 학술논문

目的评价二甲双胍(MTF)治疗枸橼酸氯米芬(CC)抵抗型(对CC的促排卵治疗3个周期无反应)多囊卵巢综合征( PCOS)不孕患者的疗效.方法通过PubMed数据库、Cochrane图书馆数据库、荷兰医学文摘(EMBASE)及美国OVID、EBSCO数据库等,收集国外已发表的有关MTF联合CC与继续单纯CC治疗的CC抵抗型PCOS不孕患者疗效对比的随机对照临床试验,按纳入和排除标准进行筛选,对纳入的研究进行质量评价,以治疗后排卵率、妊娠率作为终点指标,使用统计软件RevMan 5.0完成荟萃分析.结果经筛选,共纳入8个研究的333例CC抵抗型PCOS不孕患者.与单纯CC治疗比较,MTF联合CC能明显提高CC抵抗型PCOS不孕患者的排卵率(OR=7.31,95％ CI为2.57 ～20.76)及妊娠率(OR=7.93,95％ CI为2.45 ～ 25.63),差异均有统计学意义(P＜0.05).结论 MTF联合CC治疗CC抵抗型PCOS不孕患者,能提高其排卵率和妊娠率.
목적 평개이갑쌍고(MTF)치료구연산록미분(CC)저항형(대CC적촉배란치료3개주기무반응)다낭란소종합정( PCOS)불잉환자적료효.방법 통과PubMed수거고、Cochrane도서관수거고、하란의학문적(EMBASE)급미국OVID、EBSCO수거고등,수집국외이발표적유관MTF연합CC여계속단순CC치료적CC저항형PCOS불잉환자료효대비적수궤대조림상시험,안납입화배제표준진행사선,대납입적연구진행질량평개,이치료후배란솔、임신솔작위종점지표,사용통계연건RevMan 5.0완성회췌분석.결과 경사선,공납입8개연구적333례CC저항형PCOS불잉환자.여단순CC치료비교,MTF연합CC능명현제고CC저항형PCOS불잉환자적배란솔(OR=7.31,95％ CI위2.57 ～20.76)급임신솔(OR=7.93,95％ CI위2.45 ～ 25.63),차이균유통계학의의(P＜0.05).결론 MTF연합CC치료CC저항형PCOS불잉환자,능제고기배란솔화임신솔.
Objective To evaluate the efficacy of metformin(MTF) in treatment of clomiphene (CC)-resistant patients with polycystic ovary syndrome (PCOS).Methods The published articles of randomized controlled trial (RCT) of comparison of MTF combined with CC and CC alone in treatment of CC-resistant PCOS were searched in PubMed,EMBASE,OVID,EBSCO databases and Cochrane Library,and these studies were screened under inclusion and exclusion criteria.The quality of included studies and extract data of comparison of ovulation rates and pregnancy rates were evaluated.And the Meta-analysis using statistic software RevMan 5.0 was completed.Result Total of 333 patients in total 8 trials were included.Meta analysis showed that MTF plus CC led to a significantly higher clinical ovulation rate ( OR =7.31,95 ％ CI:2.57 - 20.76,P ＜ 0.05 ) and pregnancy rate ( OR =7.93,95 ％ CI:2.45 - 25.63,P ＜ 0.05 ) than that of CC alone.Conclusion MTF can increase ovulation and pregnancy rates of CC-resistant PCOS women.