CAJ | 학술논문

目的探讨系统性红斑狼疮(SLE)合并血脂异常患者血管内皮功能状况以及阿托伐他汀钙对其IIIL脂和血管内皮功能的影响.方法控制影响血管内皮功能因素后纳入观察组的67例SLB合并血脂异常患者.以及年龄、性别匹配的对照组55名,用彩色超声检测两组血管内皮功能加以对比;并予观察组口服阿托伐他汀钙片20 mg,1次/d,疗程为十二周.服药后再次超声复查血管内皮功能以及血脂情况,分析阿托伐他汀钙对sLE合并血脂异常患者血脂及血管内皮功能的影响.结果观察组血管内皮功能较对照组明显下降(P<0.05),服药后较服药前TG、LDL-C、apoBl00明显降低(P<0.05),HDL-C、apoA,明显升高(P<0.05),血管内皮功能明显改善(P<0.05).结论 SLE合并血脂代谢异常患者存在血管内皮功能障碍ECD,阿托伐他汀钙可以升高HDL-C,降低LDL-C及TG,调整SLE合并血脂异常患者的ECD,防治SLE患者动脉粥样硬化的发生和发展.
목적 탐토계통성홍반랑창(SLE)합병혈지이상환자혈관내피공능상황이급아탁벌타정개대기IIIL지화혈관내피공능적영향.방법 공제영향혈관내피공능인소후납입관찰조적67례SLB합병혈지이상환자.이급년령、성별필배적대조조55명,용채색초성검측량조혈관내피공능가이대비;병여관찰조구복아탁벌타정개편20 mg,1차/d,료정위십이주.복약후재차초성복사혈관내피공능이급혈지정황,분석아탁벌타정개대sLE합병혈지이상환자혈지급혈관내피공능적영향.결과 관찰조혈관내피공능교대조조명현하강(P<0.05),복약후교복약전TG、LDL-C、apoBl00명현강저(P<0.05),HDL-C、apoA,명현승고(P<0.05),혈관내피공능명현개선(P<0.05).결론 SLE합병혈지대사이상환자존재혈관내피공능장애ECD,아탁벌타정개가이승고HDL-C,강저LDL-C급TG,조정SLE합병혈지이상환자적ECD,방치SLE환자동맥죽양경화적발생화발전.
Objective To investigate the change of vascular endothelial function (EF)in patients of systemic lupus erythematosus ( SLE ) with dyslipidemia and the influence of atorvastafin on the EF and plasma lipid. Methods After controlled by other factors that could impair EF,67 patients of SLE with dyslipidemia were enrolled as observation group( atorvastafin 20 mg, per night for 12 weeks)and 55 control subjectives were chosen by match-pairing of age and sex. Assessment of EF was performed by color Doppler ultrasound. After treatment,the measurement of plasma lipid and EF were repeated. Results After treatment, the EF of observa- tion group was improved compared with control group( P < 0. 05 ). The plasma TG LDL-c and apoB100 levels were lower(P <0. 05), HDL-c and apoA levels were higher(P <0. 05) and the improvement of EF was better in observation group after treatment ( P < 0. 05 ). Conclusion The vascular endothelial function was impaired in patients of SLE with dyslipidemia. Atorvastafin could modify the metabolism of lipid, improve the vascular endo-thelial function and protect the patients from the development of atheroclerosis.