中华糖尿病杂志
中華糖尿病雜誌
중화당뇨병잡지
CHINES JOURNAL OF DLABETES MELLITUS
2010年
5期
339-343
,共5页
视黄醇结合蛋白4%视黄醇结合蛋白4/甲状腺素转运蛋白比值%糖尿病视网膜病
視黃醇結閤蛋白4%視黃醇結閤蛋白4/甲狀腺素轉運蛋白比值%糖尿病視網膜病
시황순결합단백4%시황순결합단백4/갑상선소전운단백비치%당뇨병시망막병
Retinal binding protein 4%Retinal binding protein 4/transthyretin%Diabetic retinopathy
目的 通过测定正常糖调节者、合并与未合并糖尿病视网膜病(DR)的2型糖尿病(T2DM)患者血清视黄醇结合蛋白4(RBP4)浓度以及视黄醇结合蛋白4/甲状腺素转运蛋白(RBP4/TTR)比值探讨RBP4在DR中的意义.方法 选取2008年1月至9月苏州大学附属第一医院内分泌科收治的72例2型糖尿病住院患者,应用酶联免疫法和全自动生化分析仪检测35例合并DR的T2DM患者(DR组)血清RBP4、TTR、真胰岛素、C肽、糖化血红蛋白等,并与37例非DR的2型糖尿病患者(NDR组)和30名正常糖调节者(NGR组)作横断面对照.所有入选对象均符合以下标准:(1)排除肝肾疾病,并且入院后生化检查无肝酶、胆红素、白蛋白及球蛋白异常;尿蛋白/尿肌酐＜0.2,肾小球滤过率＞90 ml/min;(2)无营养不良及体重指数(BMI)＜19 kg/m2;(3)无感染及应激状态,且血清超敏C反应蛋白＜3.0 mg/L;(4)1个月内未服用维生素A、铁剂及影响其代谢的药物.采用方差分析、t检验、二元Logistic回归等进行统计学分析.结果 DR组RBP4/TTR较NDR组及NGR组显著增高(0.12±0.06、0.09±0.04、0.072±0.021,F=9.562,P＜0.05).DR组RBP4与NGR组比较差异有统计学意义[(16±4)、(13±3)mg/L,t=3.74,P＜0.05],但与NDR组无统计学差异[(15±4)、(15±3)mg/L,t=1.73,P＞0.05].分别将RBP4和RBP4/TTR引入二元Logistic回归分析,发现RBP4(B=0.214,OR=1.239,P＜0.05)和RBP4/TTR(B=0.718,OR=2.051,P＜0.05)均为DR的危险因素.结论 血清RBP4可能在T2DM发生DR的过程中起作用;血清RBP4/TTR比值在评估DR危险因素时的价值要优于血清RBP4浓度.
目的 通過測定正常糖調節者、閤併與未閤併糖尿病視網膜病(DR)的2型糖尿病(T2DM)患者血清視黃醇結閤蛋白4(RBP4)濃度以及視黃醇結閤蛋白4/甲狀腺素轉運蛋白(RBP4/TTR)比值探討RBP4在DR中的意義.方法 選取2008年1月至9月囌州大學附屬第一醫院內分泌科收治的72例2型糖尿病住院患者,應用酶聯免疫法和全自動生化分析儀檢測35例閤併DR的T2DM患者(DR組)血清RBP4、TTR、真胰島素、C肽、糖化血紅蛋白等,併與37例非DR的2型糖尿病患者(NDR組)和30名正常糖調節者(NGR組)作橫斷麵對照.所有入選對象均符閤以下標準:(1)排除肝腎疾病,併且入院後生化檢查無肝酶、膽紅素、白蛋白及毬蛋白異常;尿蛋白/尿肌酐＜0.2,腎小毬濾過率＞90 ml/min;(2)無營養不良及體重指數(BMI)＜19 kg/m2;(3)無感染及應激狀態,且血清超敏C反應蛋白＜3.0 mg/L;(4)1箇月內未服用維生素A、鐵劑及影響其代謝的藥物.採用方差分析、t檢驗、二元Logistic迴歸等進行統計學分析.結果 DR組RBP4/TTR較NDR組及NGR組顯著增高(0.12±0.06、0.09±0.04、0.072±0.021,F=9.562,P＜0.05).DR組RBP4與NGR組比較差異有統計學意義[(16±4)、(13±3)mg/L,t=3.74,P＜0.05],但與NDR組無統計學差異[(15±4)、(15±3)mg/L,t=1.73,P＞0.05].分彆將RBP4和RBP4/TTR引入二元Logistic迴歸分析,髮現RBP4(B=0.214,OR=1.239,P＜0.05)和RBP4/TTR(B=0.718,OR=2.051,P＜0.05)均為DR的危險因素.結論 血清RBP4可能在T2DM髮生DR的過程中起作用;血清RBP4/TTR比值在評估DR危險因素時的價值要優于血清RBP4濃度.
목적 통과측정정상당조절자、합병여미합병당뇨병시망막병(DR)적2형당뇨병(T2DM)환자혈청시황순결합단백4(RBP4)농도이급시황순결합단백4/갑상선소전운단백(RBP4/TTR)비치탐토RBP4재DR중적의의.방법 선취2008년1월지9월소주대학부속제일의원내분비과수치적72례2형당뇨병주원환자,응용매련면역법화전자동생화분석의검측35례합병DR적T2DM환자(DR조)혈청RBP4、TTR、진이도소、C태、당화혈홍단백등,병여37례비DR적2형당뇨병환자(NDR조)화30명정상당조절자(NGR조)작횡단면대조.소유입선대상균부합이하표준:(1)배제간신질병,병차입원후생화검사무간매、담홍소、백단백급구단백이상;뇨단백/뇨기항＜0.2,신소구려과솔＞90 ml/min;(2)무영양불량급체중지수(BMI)＜19 kg/m2;(3)무감염급응격상태,차혈청초민C반응단백＜3.0 mg/L;(4)1개월내미복용유생소A、철제급영향기대사적약물.채용방차분석、t검험、이원Logistic회귀등진행통계학분석.결과 DR조RBP4/TTR교NDR조급NGR조현저증고(0.12±0.06、0.09±0.04、0.072±0.021,F=9.562,P＜0.05).DR조RBP4여NGR조비교차이유통계학의의[(16±4)、(13±3)mg/L,t=3.74,P＜0.05],단여NDR조무통계학차이[(15±4)、(15±3)mg/L,t=1.73,P＞0.05].분별장RBP4화RBP4/TTR인입이원Logistic회귀분석,발현RBP4(B=0.214,OR=1.239,P＜0.05)화RBP4/TTR(B=0.718,OR=2.051,P＜0.05)균위DR적위험인소.결론 혈청RBP4가능재T2DM발생DR적과정중기작용;혈청RBP4/TTR비치재평고DR위험인소시적개치요우우혈청RBP4농도.
Objective To study the meaning of serum retinal binding protein 4 in type 2 diabetes with diabetic retinopathy. Methods Serum RBP4 and transthyretin (TTR) of 35 patients with diabetic retinopathy (DR) were crosssectionally measured by enzyme linked immunosorbent assay (ELISA). Thirtyseven diabetic patients without diabetic retinopathy (NDR) and 30 nondiabetic subjects (NGR) were enrolled as controls. In each subject, fasting values of glucose, insulin, total cholesterol ( TC), triglyceride (TG), low density lipoprotein (LDL), high density lipoprotein (HDL), C-reactive protein (CRP), and HbA1c were determined. Results Serum RBP4 level in patients with DR was significantly higher than that in NGR( ( 15 ± 4 ) mg/L, ( 13 ± 3 ) mg/L, t = 3.74, P ＜ 0.05 ), but there was no difference between patients with and without DR ( ( 15 ± 4) mg/L, ( 15 ± 3 ) mg/L, t = 1.73, P = 0.073 ). However, the RBP4/TTR ratio in patients with DR was markedly increased than that NDR and NGR (0.12 ±0.06,0.09 ±0.04 and 0.072 ± 0.021, F = 9.562, both P ＜ 0.05 ). In addition, RBP4 and the RBP4/TTR ratio were analyzed respectively according to Binary Logistic Backward·RBP4 ( B = 0.214, OR = 1.239, P ＜ 0.05 ) and RBP4/TTR ratio ( B = 0.718, OR = 2.051, P ＜ 0.05 ) were found to be the risk factors for diabetic retinopathy, and the RBP4/TTR ratio was more contributive than serum RBP4 concentration in type 2 diabetes companied with diabetic retinopathy. Conclusions The RBP4/TTR ratio is more valuable than serum RBP4 concentration to evaluate risk factor of diabetic retinopathy, and RBP4 may be a novel causative agent for diabetic retinopathy of type 2 diabetes mellitus.
