中国危重病急救医学
中國危重病急救醫學
중국위중병급구의학
CHINESE CRITICAL CARE MEDICINE
2012年
6期
355-356
,共2页
肺血栓栓塞症%尿激酶%重组组织型纤溶酶原激活剂%溶栓
肺血栓栓塞癥%尿激酶%重組組織型纖溶酶原激活劑%溶栓
폐혈전전새증%뇨격매%중조조직형섬용매원격활제%용전
Pulmonary thromboembolism%Urokinase%Recombinant tissue plasminogen activator%Thrombolysis
目的 比较尿激酶(UK)和基因重组组织型纤溶酶原激活剂(rt-PA)治疗急性肺血栓栓塞症(PTE)的经济效益比,为寻找适宜的溶栓药物提供依据.方法 回顾性分析2006年1月至2011年12月在唐山市工人医院诊断为PTE的156例患者资料,均采用溶栓治疗,其中应用UK 1×104 U/kg治疗104例,应用rt-PA 50 mg治疗52例,比较这两种药物的治疗效果、并发症发生率以及医疗费用.结果 UK组症状的缓解率、血管再通率以及并发症发生率与rt-PA组比较差异均无统计学意义(68.2％比71.2％,63.5％比73.1％,14.4％比17.3％,均P＞0.05)；而UK组治疗费用(元)显著低于rt-PA组(408±120比6500±634,P＜0.01).结论 应用UK治疗PTE的效果与rt-PA一致,但可节约医疗费用.
目的 比較尿激酶(UK)和基因重組組織型纖溶酶原激活劑(rt-PA)治療急性肺血栓栓塞癥(PTE)的經濟效益比,為尋找適宜的溶栓藥物提供依據.方法 迴顧性分析2006年1月至2011年12月在唐山市工人醫院診斷為PTE的156例患者資料,均採用溶栓治療,其中應用UK 1×104 U/kg治療104例,應用rt-PA 50 mg治療52例,比較這兩種藥物的治療效果、併髮癥髮生率以及醫療費用.結果 UK組癥狀的緩解率、血管再通率以及併髮癥髮生率與rt-PA組比較差異均無統計學意義(68.2％比71.2％,63.5％比73.1％,14.4％比17.3％,均P＞0.05)；而UK組治療費用(元)顯著低于rt-PA組(408±120比6500±634,P＜0.01).結論 應用UK治療PTE的效果與rt-PA一緻,但可節約醫療費用.
목적 비교뇨격매(UK)화기인중조조직형섬용매원격활제(rt-PA)치료급성폐혈전전새증(PTE)적경제효익비,위심조괄의적용전약물제공의거.방법 회고성분석2006년1월지2011년12월재당산시공인의원진단위PTE적156례환자자료,균채용용전치료,기중응용UK 1×104 U/kg치료104례,응용rt-PA 50 mg치료52례,비교저량충약물적치료효과、병발증발생솔이급의료비용.결과 UK조증상적완해솔、혈관재통솔이급병발증발생솔여rt-PA조비교차이균무통계학의의(68.2％비71.2％,63.5％비73.1％,14.4％비17.3％,균P＞0.05)；이UK조치료비용(원)현저저우rt-PA조(408±120비6500±634,P＜0.01).결론 응용UK치료PTE적효과여rt-PA일치,단가절약의료비용.
Objective To compare the costs and benefits of different thrombolytic strategies with urokinase (UK) and recombinant tissue plasminogen activator (rt-PA) in treating acute pulmonary thromboembolism (PTE),with aim of providing optimal thrombolytic medication.Methods Data from 156 patients with PTE from Jannary 2006 to December 2011 in Tangshan Gongren Hospital was analyzed retrospectively.All patients were treated by thrombolysis,among them 104 patients were treated with 1 × 104 U/kg of UK and 52 patients were treated with 50 mg of rt-PA.The therapeutic effects of two methods were compared and the complication incidence rate and medical cost were also compared.Results There were no significant differences in the symptom remission rate,the recanalization rate,and the incidence of complications between UK group and rt-PA group (68.2％ vs.71.2％,63.5％ vs.73.1％,14.4％ vs.17.3％,all P＞0.05 ),but the treatment cost (yuan) of UK group was remarkably lower than that of rt-PA group (408 ±120 vs.6500 +634,P＜0.01).Conclusion Different thrombolytic strategies with UK and rt-PA yield similarefficacy,however,the medical cost was significant decreased in UK group.
