中华神经医学杂志
中華神經醫學雜誌
중화신경의학잡지
CHINESE JOURNAL OF NEUROMEDICINE
2009年
6期
608-609
,共2页
练学淦%徐进%赵建法%祝育青%于苏文
練學淦%徐進%趙建法%祝育青%于囌文
련학감%서진%조건법%축육청%우소문
帕金森病%交感神经皮肤反应%自主神经功能障碍
帕金森病%交感神經皮膚反應%自主神經功能障礙
파금삼병%교감신경피부반응%자주신경공능장애
Parkinson's diease%Sympathetic skin response%Autonomic nerve dysfunction
目的 探讨交感神经皮肤反应(SSR)对帕金森病自主神经功能障碍的诊断价值.方法 对解放军第一○二医院神经内科自2006年7月至2008年8月门诊或住院的47例帕金森病患者及与之相匹配的20例健康人进行SSR检测,并对其中有自主神经功能障碍患者与无自主神经功能障碍患者的结果进行对比分析. 结果帕金森病患者与健康人相比,上肢潜伏期明显延长(1.55±0.18 vs 1.42±0.29),波幅明显降低(1.87±0.26 vs 2.56±1.47);下肢潜伏期明显延长(2.13±0.16vs 2.04±0.27),波幅明显降低(0.49±0.21 vs 0.76±0.39),差异均有统计学意义(P<0.05).有自主神经功能障碍患者与无自主神经功能障碍患者相比,上肢潜伏期明显延长(1.56 ± 0.17 vs 1.53 ± 0.15),波幅明显降低(1.75±0.21 vs 1.89±0.33);下肢潜伏期明显延长(2.17 ± 0.18 vs 2.08±0.24),波幅明显降低(0.46±0.20 vs 0.51±0.17),差异均有统计学意义(P<0.05). 结论 SSR检测结果与患者临床表现相一致,其对帕金森病患者的自主神经功能障碍有诊断价值.
目的 探討交感神經皮膚反應(SSR)對帕金森病自主神經功能障礙的診斷價值.方法 對解放軍第一○二醫院神經內科自2006年7月至2008年8月門診或住院的47例帕金森病患者及與之相匹配的20例健康人進行SSR檢測,併對其中有自主神經功能障礙患者與無自主神經功能障礙患者的結果進行對比分析. 結果帕金森病患者與健康人相比,上肢潛伏期明顯延長(1.55±0.18 vs 1.42±0.29),波幅明顯降低(1.87±0.26 vs 2.56±1.47);下肢潛伏期明顯延長(2.13±0.16vs 2.04±0.27),波幅明顯降低(0.49±0.21 vs 0.76±0.39),差異均有統計學意義(P<0.05).有自主神經功能障礙患者與無自主神經功能障礙患者相比,上肢潛伏期明顯延長(1.56 ± 0.17 vs 1.53 ± 0.15),波幅明顯降低(1.75±0.21 vs 1.89±0.33);下肢潛伏期明顯延長(2.17 ± 0.18 vs 2.08±0.24),波幅明顯降低(0.46±0.20 vs 0.51±0.17),差異均有統計學意義(P<0.05). 結論 SSR檢測結果與患者臨床錶現相一緻,其對帕金森病患者的自主神經功能障礙有診斷價值.
목적 탐토교감신경피부반응(SSR)대파금삼병자주신경공능장애적진단개치.방법 대해방군제일○이의원신경내과자2006년7월지2008년8월문진혹주원적47례파금삼병환자급여지상필배적20례건강인진행SSR검측,병대기중유자주신경공능장애환자여무자주신경공능장애환자적결과진행대비분석. 결과파금삼병환자여건강인상비,상지잠복기명현연장(1.55±0.18 vs 1.42±0.29),파폭명현강저(1.87±0.26 vs 2.56±1.47);하지잠복기명현연장(2.13±0.16vs 2.04±0.27),파폭명현강저(0.49±0.21 vs 0.76±0.39),차이균유통계학의의(P<0.05).유자주신경공능장애환자여무자주신경공능장애환자상비,상지잠복기명현연장(1.56 ± 0.17 vs 1.53 ± 0.15),파폭명현강저(1.75±0.21 vs 1.89±0.33);하지잠복기명현연장(2.17 ± 0.18 vs 2.08±0.24),파폭명현강저(0.46±0.20 vs 0.51±0.17),차이균유통계학의의(P<0.05). 결론 SSR검측결과여환자림상표현상일치,기대파금삼병환자적자주신경공능장애유진단개치.
Objective To assess the value of detecting sympathetic skin response (SSR) in the diagnosis of autonomic dysfunction in patients with Parkinson disease (PD). Methods SSR measurement was performed in 47 PD patients and 20 healthy control subjects and the results were compared. The SSR was also comparatively analyzed between patients with and those without autonomic dysfimction. Results Compared with the healthy controls, the PD patients showed significantly lowered mean amplitude (2.56±1.47 vs 1.87±0.26, P<0.05) and prolonged latency (1.42±0.29 vs 1.55± 0.18, P<0.05) of the SSR in the upper limbs, with also lowered mean amplitude (0.76±0.39 vs 0.49±0.21, P<0.05) and prolonged latency (2.04±0.27 vs 2.13±0.16, P<0.05) in the lower limbs. Compared with the PD patients without autonomic dysfunction, those having autonomic dysfunction showed significantly lowered mean amplitude (1.89±0.33 vs 1.75±0.21, P<0.05) and prolonged latency (1.53±0.15 vs 1.56±0.17, P<0.05) of SSR in the upper limbs and lowered mean amplitude (0.51±0.17 vs 0.46±0.20,P<0.05) and prolonged latency (2.08±0.24 vs 2.17±0.18, P<0.05) in the lower limbs. Conclusion The results of SSR measurements are consistent with the clinical manifestations of the PD patients. SSR can be of value in the diagnosis of autonomic nerve dysfunction in PD.
