CAJ | 학술논문

目的观察广谱细胞保护剂氨磷汀在宫颈癌全盆腔放疗中对肠道功能的保护作用.方法选择20例病理诊断明确的宫颈癌患者(Ⅱb～Ⅳ),随机分为两组,观察组10例,放疗前应用氨磷汀(放疗总剂量DT:35～40 Gy,3～4周,放疗后视情况可手术).对照组10例,单纯放射治疗(总剂量DT:35～40 Gy,3～4周,放疗后视情况可手术).比较两组间放疗后肠道功能的变化情况.结果观察组10例中2例出现2～3级肠道不良反应,发生率为20%.对照组10例中7例出现2～3级肠道不良反应,发生率为70%.两组比较,观察组放疗后肠道不良反应比对照组明显减轻,差异有统计学意义(P<0.05).结论氨磷汀在宫颈癌全盆腔放疗中对肠道功能具有保护作用.
목적 관찰엄보세포보호제안린정재궁경암전분강방료중대장도공능적보호작용.방법 선택20례병리진단명학적궁경암환자(Ⅱb～Ⅳ),수궤분위량조,관찰조10례,방료전응용안린정(방료총제량DT:35～40 Gy,3～4주,방료후시정황가수술).대조조10례,단순방사치료(총제량DT:35～40 Gy,3～4주,방료후시정황가수술).비교량조간방료후장도공능적변화정황.결과 관찰조10례중2례출현2～3급장도불량반응,발생솔위20%.대조조10례중7례출현2～3급장도불량반응,발생솔위70%.량조비교,관찰조방료후장도불량반응비대조조명현감경,차이유통계학의의(P<0.05).결론 안린정재궁경암전분강방료중대장도공능구유보호작용.
Objective To observe the protective effect of cell broad-spectrum protection agent amifostine for intestinal function in the whole pelvic radiation therapy of cervical cancer.Methods Choosed 20 patients with pathological diagnosis of cervical cancer in patients with clear-cut(Ⅱb-Ⅳ)and the patients were randomly divided into two groups.The 10 cases of observation group applied amifostine before the application of radiation(of the total radiation dose DT:35-40 GY,3-4 weeks,surgery after radiotherapy,as the case may be).Control group of 10 cases,were treated with radiation alone(total dose of DT:35-40 Gy,3-4 weeks,surgery after radiation,as the case may be).Comparison between two groups of intestinal function changes after radiotherapy.Resluts In the group observed,2 cases occurred in 10 cases of grade 2-3 intestinal side effects,the incidence rate was 20%.In control group,7 cases occurred in 10 cases of grade 2-3 intestinal side effects,the incidence rate was 70%.Comparing the two groups,intestinal side effects of the group observed significantly reduced after radiation therapy,there was statistically significant difference(P<0.05).Conclusions Amifostine can protect intestinal function in the whole pelvic radiation therapy of cervical cancer.