CAJ | 학술논문

目的寻求反映肝纤维化的无创性检查。方法联合检测48例各种类型的肝病血清Ⅲ前胶原(serum typeⅢprocollagen，PCⅢ)、透明质酸(hyaluronate acid，HA)、血清Ⅳ型胶原(serum typeⅣprocogen，PCⅣ)，并与其肝组织病变对照研究。结果显示血清HA、PCⅢ和PCⅣ水平在慢性肝炎轻度、中度、重度和重型肝炎呈现进行性升高。血清HA、PCⅢ和PCⅣ随肝组织炎症活动指数和肝组织纤维化程度加重而升高。结论若能去除炎症因素的影响，可显著提高这些指标预测肝纤维化的准确性。
목적심구반영간섬유화적무창성검사。방법연합검측48례각충류형적간병혈청Ⅲ전효원(serum typeⅢprocollagen，PCⅢ)、투명질산(hyaluronate acid，HA)、혈청Ⅳ형효원(serum typeⅣprocogen，PCⅣ)，병여 기간조직병변대조연구。결과현시혈청HA、PCⅢ화PCⅣ수평재만성간염경도、중도、중도화중형간염정현 진행성승고。혈청HA、PCⅢ화PCⅣ수간조직염증활동지수화간조직섬유화정도가중이승고。결론약능거 제염증인소적영향，가현저제고저사지표예측간섬유화적준학성。
Purpose To establish sensitive and reliable serum marker on liver fibrosis for early clinical diagnosis. Methods Serum hyaluronate acid,type Ⅲ procollagen and type Ⅳ procogen of 48 patients with viral hepatitis were analyzed by radioimmunoassay and ELISA respectively. Results The serum HA, PCⅢ and PCⅣ level increased gradually with the progress of the disease. Their levels were correlated distinctly with the index of hepatic activity of inflammation and that of fibrosis. Conclusions The value of serum HA,PCⅢ and PCⅣ in predicting liver fibrosis will be enhanced ff the effect of inflammation could be excluded.