中国循证医学杂志
中國循證醫學雜誌
중국순증의학잡지
CHINESE JOURNAL OF EVIDENCE-BASED MEDICINE
2010年
3期
311-315
,共5页
覃青%傅一笑%蒙华庆%李涛%罗庆华%欧颖%陈品红%杜莲%邱海棠%高玉峰%郑玉萍%邱田
覃青%傅一笑%矇華慶%李濤%囉慶華%歐穎%陳品紅%杜蓮%邱海棠%高玉峰%鄭玉萍%邱田
담청%부일소%몽화경%리도%라경화%구영%진품홍%두련%구해당%고옥봉%정옥평%구전
双生子%精神健康%遗传%发育和健康状况评定(DAWBA)
雙生子%精神健康%遺傳%髮育和健康狀況評定(DAWBA)
쌍생자%정신건강%유전%발육화건강상황평정(DAWBA)
Twins%Mental health%Genetic%Development and Well-Bing Assessment (DAWBA)
目的 了解遗传因素对儿童双生子精神健康发育的影响.方法 通过教委和学校募集6～16岁在同一家庭中抚养并就读于同一所学校的双生子.签署知情同意书后,用发育和健康状况评定量表(Development and Well-Bing Assessment,DAWBA)中文版向双生子父母调查双生子的精神健康发育状况.同时采集双生子的颊粘膜 标本提取DNA进行卵型鉴定.结果 共募集到双生子102对,完成同卷调查93对,其中同卵双生子(MZ)50对,异卵双生子(DZ)43对.在DAWBA的情绪、行为症状及其症状产生的影响部分,计算机诊断结果显示情绪障碍中的分离性焦虑(MZ组相关系数(r)=0.821,P<0.01;DZ组r=0.348,P<0.01)、广泛性焦虑(MZ组r=0.546,P<0.01;DZ组r=0.309,P<0.01)、特殊恐怖症状(MZ组r=0.849,P<0.01;DZ组r=0.726,P<0.01)及对立,品行障碍(MZ组r=0.237,P<0.01:DZ组r=0.163,P<0.01)、注意力缺陷-多动障碍(MZ组r=0.640,P<0.01;DZ组r=0.198,P<0.01),孤独症症状(MZ组r=0.680,P<0.01;DZ组r=0.372,P<0.01),MZ组r大于DZ组.结论 在影响儿童双生子精神健康发育的因素中,遗传因素起重要作用.
目的 瞭解遺傳因素對兒童雙生子精神健康髮育的影響.方法 通過教委和學校募集6～16歲在同一傢庭中撫養併就讀于同一所學校的雙生子.籤署知情同意書後,用髮育和健康狀況評定量錶(Development and Well-Bing Assessment,DAWBA)中文版嚮雙生子父母調查雙生子的精神健康髮育狀況.同時採集雙生子的頰粘膜 標本提取DNA進行卵型鑒定.結果 共募集到雙生子102對,完成同捲調查93對,其中同卵雙生子(MZ)50對,異卵雙生子(DZ)43對.在DAWBA的情緒、行為癥狀及其癥狀產生的影響部分,計算機診斷結果顯示情緒障礙中的分離性焦慮(MZ組相關繫數(r)=0.821,P<0.01;DZ組r=0.348,P<0.01)、廣汎性焦慮(MZ組r=0.546,P<0.01;DZ組r=0.309,P<0.01)、特殊恐怖癥狀(MZ組r=0.849,P<0.01;DZ組r=0.726,P<0.01)及對立,品行障礙(MZ組r=0.237,P<0.01:DZ組r=0.163,P<0.01)、註意力缺陷-多動障礙(MZ組r=0.640,P<0.01;DZ組r=0.198,P<0.01),孤獨癥癥狀(MZ組r=0.680,P<0.01;DZ組r=0.372,P<0.01),MZ組r大于DZ組.結論 在影響兒童雙生子精神健康髮育的因素中,遺傳因素起重要作用.
목적 료해유전인소대인동쌍생자정신건강발육적영향.방법 통과교위화학교모집6～16세재동일가정중무양병취독우동일소학교적쌍생자.첨서지정동의서후,용발육화건강상황평정량표(Development and Well-Bing Assessment,DAWBA)중문판향쌍생자부모조사쌍생자적정신건강발육상황.동시채집쌍생자적협점막 표본제취DNA진행란형감정.결과 공모집도쌍생자102대,완성동권조사93대,기중동란쌍생자(MZ)50대,이란쌍생자(DZ)43대.재DAWBA적정서、행위증상급기증상산생적영향부분,계산궤진단결과현시정서장애중적분리성초필(MZ조상관계수(r)=0.821,P<0.01;DZ조r=0.348,P<0.01)、엄범성초필(MZ조r=0.546,P<0.01;DZ조r=0.309,P<0.01)、특수공포증상(MZ조r=0.849,P<0.01;DZ조r=0.726,P<0.01)급대립,품행장애(MZ조r=0.237,P<0.01:DZ조r=0.163,P<0.01)、주의력결함-다동장애(MZ조r=0.640,P<0.01;DZ조r=0.198,P<0.01),고독증증상(MZ조r=0.680,P<0.01;DZ조r=0.372,P<0.01),MZ조r대우DZ조.결론 재영향인동쌍생자정신건강발육적인소중,유전인소기중요작용.
Objective To investigate the impact of genetic factors on mental health status in child and adolescent twins. Methods A total of 102 pairs of twins aged 6 to 16 years were recruited with the support from educational committees and schools. After the guardians of these twins had signed an informed consent form, the Chinese version growth and the state of health evaluation (Development and Well-Bing Assessment, DAWBA) were completed by the parents of these twins to investigate their mental health status. Buccal mucosa samples were collected from all twins for DNA extraction and zygosity identification test. Result A total of 102 pairs of twins were recruited, among whom 93 pairs finished the investigation, including 50 monozygotic pairs and 43 dizygotic pairs. The results of emotional symptoms and behavior symptoms and the impact of symptoms from the DAWBA screening questionnaire showed that the intrapair correlation coeficien of the emotional disorder and the oppositional/conduct disorder and the impact in monozygotic twins were more remarkable than those in dizygotie twins, including separation anxiety (MZ group correlation coefficient (r) = 0.821, P<0.01; DZ group r=0.348, P<0.01), generalized anxiety (MZ group r=0.546, P<0.01; DZ group r=0.309, P<0.01), a special terror symptoms (MZ group r=0.849, P<0.01; DZ group r=0.726, P<0.01), and oppositional defiant /conduct disorder (MZ group r=0.237, P<0.01; DZ group r=0.163, P<0.01), attention deficit-hyperactivity disorder (MZ group r=0.640, P<0.01; DZ group r=0.198, P<0.01), autistic symptoms (MZ group r=0.680, P<0.01; DZ group r=0.372, P<0.01). Conclusion Genetic factors play an important role in mental health status of child twins.
