CAJ | 학술논문

目的观察复方阿胶浆联合环磷酰胺对移植性小鼠lewis肺癌抑瘤率的影响.方法构建lewis肺癌移植瘤模型,按体重随机分为模型对照组、环磷酰胺组(CTX组)、复方阿胶浆组、复方阿胶浆大剂量联合环磷酰胺组(联合用药1组)、复方阿胶浆中剂量联合环磷酰胺组(联合用药2组)、复方阿胶浆小剂量联合环磷酰胺组(联合用药3组)共6组各10只.模型组给予生理盐水0.4 ml灌胃,1次/d,共给药12次;CTX组隔日腹腔注射CTX 0.2 ml,共给药6次;复方阿胶浆组给予复方阿胶浆原液0.2 ml、生理盐水0.2 ml混合后灌胃;联合用药1组给予复方阿胶浆原液0.4ml灌胃、隔日腹腔注射CTX 0.2ml;联合用药2组给予复方阿胶浆原液0.2 ml加生理盐水0.2 ml混合后灌胃、隔日腹腔注射CTX 0.2 ml;联合用药3组给予复方阿胶浆原液0.1 ml加生理盐水0.3ml混合后灌胃、隔日腹腔注射CTX 0.2ml.称取瘤重,按公式计算抑瘤率.结果联合用药与环磷酰胺的肿瘤抑制率均在50%以上,复方阿胶浆的肿瘤抑制率为25.88%.各实验组瘤重与模型组比较,差异有统计学意义(P<0.05),各组瘤重按上述分组顺序分别为(4.457±0.796)g、(2.105±0.651)g、(3.304±0.922)g、(1.668±0.267)g、(1.752±0.546)g、(2.075±1.061)g.复方阿胶浆不同剂量联合环磷酰胺的瘤重与环磷酰胺比较,差异无统计学意义(P>0.05).结论复方阿胶浆辅助化疗不能增加化疗药物对移植瘤杀伤的敏感性,但有一定的抑瘤趋势.
목적 관찰복방아효장연합배린선알대이식성소서lewis폐암억류솔적영향.방법 구건lewis폐암이식류모형,안체중수궤분위모형대조조、배린선알조(CTX조)、복방아효장조、복방아효장대제량연합배린선알조(연합용약1조)、복방아효장중제량연합배린선알조(연합용약2조)、복방아효장소제량연합배린선알조(연합용약3조)공6조각10지.모형조급여생리염수0.4 ml관위,1차/d,공급약12차;CTX조격일복강주사CTX 0.2 ml,공급약6차;복방아효장조급여복방아효장원액0.2 ml、생리염수0.2 ml혼합후관위;연합용약1조급여복방아효장원액0.4ml관위、격일복강주사CTX 0.2ml;연합용약2조급여복방아효장원액0.2 ml가생리염수0.2 ml혼합후관위、격일복강주사CTX 0.2 ml;연합용약3조급여복방아효장원액0.1 ml가생리염수0.3ml혼합후관위、격일복강주사CTX 0.2ml.칭취류중,안공식계산억류솔.결과 연합용약여배린선알적종류억제솔균재50%이상,복방아효장적종류억제솔위25.88%.각실험조류중여모형조비교,차이유통계학의의(P<0.05),각조류중안상술분조순서분별위(4.457±0.796)g、(2.105±0.651)g、(3.304±0.922)g、(1.668±0.267)g、(1.752±0.546)g、(2.075±1.061)g.복방아효장불동제량연합배린선알적류중여배린선알비교,차이무통계학의의(P>0.05).결론 복방아효장보조화료불능증가화료약물대이식류살상적민감성,단유일정적억류추세.
Objective To investigate the effects of Compound E-Jiao Slurry (CEJS) and Cyclophosphamide (CTX) on the inhibition of Lewis pulmonary carcinoma xenografts. Methods Tumor xenografts models were prepared and randomly divided into six groups by weight, including the control group,CTX, CEJS with the dosages of high, middle and low, with a total of ten mice in each group. The control mice were given normal saline 0.4ml by intragastric administration once daily, with a total of twelve times; The mice of CTX group were given CTX 0.2 ml by intraperitoneal injection every other day, with a total of six times; The mice of CEJS group were given CEJS 0.2 ml and saline 0.2 ml by intragastric administration; The mice of combination therapy group 1 were given CEJS 0.4 ml by intragastric administration once daily, and CTX 0.2 ml by intraperitoneal injection every other day; The mice of combination therapy group 2 were given CEJS 0.2 ml by intragastric administration once daily, and CTX 0.2 ml by intraperitoneal injection every other day; The mice of combination therapy group 3 were given CEJS 0.1 ml by intragastric administration once daily, and CTX 0.2 ml by intraperitoneal injection every other day. The weight of tumor xenografts were measured in the experiment,the inhibition rate of tumor xenografts were calculated according to the data after the dissection. Results The combination groups and CTX alone have an inhibition rate of over 50%, and the CEJS group 25.88%. In every experimental group, the weight of tumor showed statistical significance compared with the control (P<0.05). The value was(4.457±0.796)g, (2.105±0.651) g, (3.304±0.922) g, (1.668±0.267)g, (1.752±0.546)g and (2.075±1.061) g respectively according to the group sequence. There was no statistical significance of tumor weight in the groups of different dosages of CEJS plus CTX compared with the CTX group (P>0.05). Conclusion CEJS can't obviously enhance the sensitivity of tumor xenografts to CTX, but there is a trend for tumor inhibition.