国际流行病学传染病学杂志
國際流行病學傳染病學雜誌
국제류행병학전염병학잡지
INTERNATIONAL JOURNAL OF EPIDEMIOLOGY AND INFECTIOUS DISEASE
2008年
5期
346-348
,共3页
分枝杆菌,结核%NRAMP1基因%易感性
分枝桿菌,結覈%NRAMP1基因%易感性
분지간균,결핵%NRAMP1기인%역감성
Mycobacterium tuberculosis%NRAMP1 gene%Susceptibility
NRAMP1基因,又称SLC11A1基因,位于2号染色体长臂35区(2q35),包括15个外显子及内含子4中交替出现的1个外显子,长13 604 bp.NRAMP1的常见多态性基因有D543N、3′UTR、INT4和5′(GT)n等,和结核易感性相关.NRAMP1蛋白由巨噬细胞表达,是一种H+/二价阳离子的反向转运体,对巨噬细胞的功能有多效性.此文对NRAMP1基因及其和MTB的易感相关性的研究结果进行综述.
NRAMP1基因,又稱SLC11A1基因,位于2號染色體長臂35區(2q35),包括15箇外顯子及內含子4中交替齣現的1箇外顯子,長13 604 bp.NRAMP1的常見多態性基因有D543N、3′UTR、INT4和5′(GT)n等,和結覈易感性相關.NRAMP1蛋白由巨噬細胞錶達,是一種H+/二價暘離子的反嚮轉運體,對巨噬細胞的功能有多效性.此文對NRAMP1基因及其和MTB的易感相關性的研究結果進行綜述.
NRAMP1기인,우칭SLC11A1기인,위우2호염색체장비35구(2q35),포괄15개외현자급내함자4중교체출현적1개외현자,장13 604 bp.NRAMP1적상견다태성기인유D543N、3′UTR、INT4화5′(GT)n등,화결핵역감성상관.NRAMP1단백유거서세포표체,시일충H+/이개양리자적반향전운체,대거서세포적공능유다효성.차문대NRAMP1기인급기화MTB적역감상관성적연구결과진행종술.
The NRAMP1 gene, also known as SLC11A1, is located on chromosome2q35. It is comprised of 15 exons and 1 alternatively spliced exon present within intron 4. The genomic sequence of NRAMP1 spans a distance of 13 604 bp. The common polymorphisms of NRAMP1 gene, such as D543N, 3′UTR, INT4 and 5′(GT)n, are associated with human susceptibility to Mycobacterium tuberculosis. NRAMP1 protein, expressed only in professional macrophages and acted as a proton/antiporter of divalent cations, has pleiotropic effects on the function of macrophages. The review describes the relation between NRAMP1 gene and human susceptibility to Mycobacterium tuberculosis.
