国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2010年
5期
523-526
,共4页
廖土明%谢小平%谢克基%关刚强%王鹏%何燊
廖土明%謝小平%謝剋基%關剛彊%王鵬%何燊
료토명%사소평%사극기%관강강%왕붕%하신
PSA%前列腺增生症%急性尿潴留%遏尿肌收缩力
PSA%前列腺增生癥%急性尿潴留%遏尿肌收縮力
PSA%전렬선증생증%급성뇨저류%알뇨기수축력
PSA%Benign prostatic hyperplasia%Acute urinary retention%detrusor contractility
目的 探讨前列腺增生症(BPH)并急性尿潴留(AUR)后血清前列腺特异抗原(PSA)对评估膀胱尿道功能的临床意义.方法 对随机选择的36例已留置尿管的BPH并AUR患者进行尿流动力学检查,且同日行血清PSA测定并分为两组,A组16例(≤8 ng/ml)和B组20例(>8 ng/ml),分析血清PSA与各因素的相关性.结果 36例患者血清总PSA(t-PSA)(11.98±6.15)ng/ml,游离PSA(f-PSA)(2.74±0.64.)ng/ml,两者均与前列腺体积、膀胱出口梗阻(BOO)、逼尿肌收缩力有相关性(r分别为0.327、0.469,0.272、0.336,0.414、0.419,P值分别为<0.01、0.01,0.05、0.01,0.01、0.01),f/tPSA与前列腺体积有相关性(r=0.231,P<0.05),而与BOO、逼尿肌收缩力均无相关性.逼尿肌收缩力受损在A组中占81.3%(13/16),B组中占30%(6/20).结论 对已留置尿管2d以上的BPH并AUR患者,血清PSA高低可间接反映患者逼尿肌收缩力强弱,PSA≤8 ng/ml者,其收缩力受损可能性大.
目的 探討前列腺增生癥(BPH)併急性尿潴留(AUR)後血清前列腺特異抗原(PSA)對評估膀胱尿道功能的臨床意義.方法 對隨機選擇的36例已留置尿管的BPH併AUR患者進行尿流動力學檢查,且同日行血清PSA測定併分為兩組,A組16例(≤8 ng/ml)和B組20例(>8 ng/ml),分析血清PSA與各因素的相關性.結果 36例患者血清總PSA(t-PSA)(11.98±6.15)ng/ml,遊離PSA(f-PSA)(2.74±0.64.)ng/ml,兩者均與前列腺體積、膀胱齣口梗阻(BOO)、逼尿肌收縮力有相關性(r分彆為0.327、0.469,0.272、0.336,0.414、0.419,P值分彆為<0.01、0.01,0.05、0.01,0.01、0.01),f/tPSA與前列腺體積有相關性(r=0.231,P<0.05),而與BOO、逼尿肌收縮力均無相關性.逼尿肌收縮力受損在A組中佔81.3%(13/16),B組中佔30%(6/20).結論 對已留置尿管2d以上的BPH併AUR患者,血清PSA高低可間接反映患者逼尿肌收縮力彊弱,PSA≤8 ng/ml者,其收縮力受損可能性大.
목적 탐토전렬선증생증(BPH)병급성뇨저류(AUR)후혈청전렬선특이항원(PSA)대평고방광뇨도공능적림상의의.방법 대수궤선택적36례이류치뇨관적BPH병AUR환자진행뇨류동역학검사,차동일행혈청PSA측정병분위량조,A조16례(≤8 ng/ml)화B조20례(>8 ng/ml),분석혈청PSA여각인소적상관성.결과 36례환자혈청총PSA(t-PSA)(11.98±6.15)ng/ml,유리PSA(f-PSA)(2.74±0.64.)ng/ml,량자균여전렬선체적、방광출구경조(BOO)、핍뇨기수축력유상관성(r분별위0.327、0.469,0.272、0.336,0.414、0.419,P치분별위<0.01、0.01,0.05、0.01,0.01、0.01),f/tPSA여전렬선체적유상관성(r=0.231,P<0.05),이여BOO、핍뇨기수축력균무상관성.핍뇨기수축력수손재A조중점81.3%(13/16),B조중점30%(6/20).결론 대이류치뇨관2d이상적BPH병AUR환자,혈청PSA고저가간접반영환자핍뇨기수축력강약,PSA≤8 ng/ml자,기수축력수손가능성대.
Objective To evaluate the vesicourethral function in patients with acute urinary re-tention ( AUR ) secondary to benign prostatic hyperplasia (BPH) and its clinical significance by prostate-specific antigen (PSA). Methods A total of 36 patients with AUR secondary to BPH who underwent catheterization were selected randomly and underwent urodynamic study. Blood samples for serum PSA measurement were obtained in time and divided into 2 groups: A group was 16 cases(PSA≤8 ng/ml ) and B group was 20 cases( PSA > 8ng/ml ). The correlations were analyzed among serum PSA and many factors. Results Among 36 patients, total PSA was ( 11.98 ± 6.15 ) ng/ml, and free PSA was ( 2.74 ± 0.64 ) ng/ml, these two factors were correlated with prostate volume (PV), bladder outlet obstruction (BOO), detrusor contractility (r=0.327/0.46, 0.272/0.336, 0.414/0.419, respectively; P< 0.01/0.0, 0.05/0.01,0.01/0.01, respectively ).NO correlation among f/tPSA , BOO and detrusor contractility were indicated, but the correlation between f/tPSA and PV was found (r=0.231, P< 0.05).The contractility of detrusor muscle in A group were weaker in 81.3% (13/16), while 30% (6/20) in B group. Conclusions The level of of serum PSA could indirectly indicate the stronger or weaker contractility of detrusor muscle in patients underwent catheterization who presented AUR secondary to BPH. Contractility was possible weaker when PSA≤8ng/ml.
