中国医药
中國醫藥
중국의약
CHINA MEDICINE
2010年
5期
408-409
,共2页
刘启如%魏嵋%方平安%王小莉
劉啟如%魏嵋%方平安%王小莉
류계여%위미%방평안%왕소리
慢性乙型肝炎%异甘草酸镁%门冬氨酸钾镁%甘草酸二铵
慢性乙型肝炎%異甘草痠鎂%門鼕氨痠鉀鎂%甘草痠二銨
만성을형간염%이감초산미%문동안산갑미%감초산이안
Chronic hepatitis B%Magnesium Isoglycyrrhizinate%Potassium Magnesium Aspartatse%Diammonium glycyrrhizinate
目的 观察异甘草酸镁注射液治疗慢性乙型肝炎的临床疗效.方法 340例慢性乙型肝炎患者完全随机分为3组,异甘草酸镁组130例,甘利欣组126例,门冬氨酸钾镁组84例,异甘草酸镁组静脉滴注异甘草酸镁注射液150 mg/d+门冬氨酸钾镁注射液20 ml/d;甘利欣组静脉滴注甘利欣注射液50 mg/d+门冬氨酸钾镁注射液20 ml/d;门冬氨酸钾镁组静脉滴注门冬氨酸钾镁注射液20 ml/d.观察3组患者的症状、体征以及肝功能的变化,并测定治疗前后的TBIL、AST、AIT.结果 治疗30 d后异甘草酸镁组TBIL、AST、ALT分别为(28±15)μmol/L,(38±35)U/L,(39±38)U/L,甘利欣加门冬氨酸钾镁组分别为(56±29)μmol/L,(95±74)U/L,(117±81)U/L,门冬氨酸钾镁组(67±52)μmol/L,(122±92)U/L,(269±106)U/L.结论 异甘草酸镁联合门冬氨酸钾镁注射液较甘利欣联合门冬氨酸钾镁用药降酶作用显著,转氨酶反跳现象极少见.
目的 觀察異甘草痠鎂註射液治療慢性乙型肝炎的臨床療效.方法 340例慢性乙型肝炎患者完全隨機分為3組,異甘草痠鎂組130例,甘利訢組126例,門鼕氨痠鉀鎂組84例,異甘草痠鎂組靜脈滴註異甘草痠鎂註射液150 mg/d+門鼕氨痠鉀鎂註射液20 ml/d;甘利訢組靜脈滴註甘利訢註射液50 mg/d+門鼕氨痠鉀鎂註射液20 ml/d;門鼕氨痠鉀鎂組靜脈滴註門鼕氨痠鉀鎂註射液20 ml/d.觀察3組患者的癥狀、體徵以及肝功能的變化,併測定治療前後的TBIL、AST、AIT.結果 治療30 d後異甘草痠鎂組TBIL、AST、ALT分彆為(28±15)μmol/L,(38±35)U/L,(39±38)U/L,甘利訢加門鼕氨痠鉀鎂組分彆為(56±29)μmol/L,(95±74)U/L,(117±81)U/L,門鼕氨痠鉀鎂組(67±52)μmol/L,(122±92)U/L,(269±106)U/L.結論 異甘草痠鎂聯閤門鼕氨痠鉀鎂註射液較甘利訢聯閤門鼕氨痠鉀鎂用藥降酶作用顯著,轉氨酶反跳現象極少見.
목적 관찰이감초산미주사액치료만성을형간염적림상료효.방법 340례만성을형간염환자완전수궤분위3조,이감초산미조130례,감리흔조126례,문동안산갑미조84례,이감초산미조정맥적주이감초산미주사액150 mg/d+문동안산갑미주사액20 ml/d;감리흔조정맥적주감리흔주사액50 mg/d+문동안산갑미주사액20 ml/d;문동안산갑미조정맥적주문동안산갑미주사액20 ml/d.관찰3조환자적증상、체정이급간공능적변화,병측정치료전후적TBIL、AST、AIT.결과 치료30 d후이감초산미조TBIL、AST、ALT분별위(28±15)μmol/L,(38±35)U/L,(39±38)U/L,감리흔가문동안산갑미조분별위(56±29)μmol/L,(95±74)U/L,(117±81)U/L,문동안산갑미조(67±52)μmol/L,(122±92)U/L,(269±106)U/L.결론 이감초산미연합문동안산갑미주사액교감리흔연합문동안산갑미용약강매작용현저,전안매반도현상겁소견.
Objective To study the effect of Magnesium Isoglycyrrhizinate treating chronic hepatitis B.Methods Three hundred patients were randomly divided into three groups,magnesium isoglycyrrhizinate group 130 case were given magnesium isoglycyrrhizinate 150 mg/d and potassium magnesium aspartate injection 20 ml/d;ganlixin group 126 cases were given ganlixin 150 mg/d and potassium magnesium aspartate injection 20 ml/d;potassium-magnesium aspartate group 84 cases were given potassium magnesium aspartate injection 20 ml/d.The total bilirubin (TBIL),aspartate (AST) and alanine aminotransferase (ALT) were determined.Results Thirty days after treatment,the TBIL,AST,ALT of magnesium isoglycyrrhizinate group were (28±15) μmol/L,(38±35) U/L,(39±38) U/L respectively;gardixin group were (56±29) μmol/L,(95±74) U/L,(117±81) U/L;potassiummagnesium aspartate group were (67±52) μmol/L,(122±92) U/L,(269±106) U/L.Conclution Magnesium Isoglycyrrhizinate presents significant role in treatment of chronic hepatitis B,Relapse of transaminase occurred rarely.
