中华放射学杂志
中華放射學雜誌
중화방사학잡지
Chinese Journal of Radiology
2008年
5期
471-473
,共3页
谢晟%齐朝月%肖江喜%杨艳玲%蒋学祥
謝晟%齊朝月%肖江喜%楊豔玲%蔣學祥
사성%제조월%초강희%양염령%장학상
MELAS综合征%磁共振成像%灌流
MELAS綜閤徵%磁共振成像%灌流
MELAS종합정%자공진성상%관류
MELAS syndrome%Magnetic resonance imaging%Perfusion
目的 探讨MELAS综合征患者的MR脑血流灌注异常特征.方法 对13例确诊的MELAS综合征患者和13名对照组受试者行流速敏感交替反转恢复免除独立T1测量(FAIREST)序列扫描,通过后处理生成脑血流量(CBF)图,分别测量他们的双侧基底节区、丘脑、颢叶和枕叶的相对脑血流量(rCBF)值,采用多元回归法分析对照组中测量部位和侧别对rCBF值的影响,将对照组、MELAS综合征组非病灶区和病灶区的rCBF值采用单因素方差分析进行比较.结果 对照组左侧基底节区、丘脑、颞叶和枕叶的rCBF值分别为0.83±0.23、1.17±0.30、0.93±0.28和1.11±0.25,右侧基底节区、丘脑、颞叶和枕叶的rCBF值分别为0.77±0.15、1.03±0,34、1.06±0.23和1.09±0.23,多元同归分析结果显示,对照组不同测量部位和侧别对于rCBF值的影响无统计学意义(P＞0.05).对照组感兴趣区的rCBF值为1.00±0.28,MELAS组综合征非病灶区和病灶区的rCBF值分别为1.01±0.31和1.95±0.43,MELAS综合征组病灶区的rCBF值大于非病灶区和对照组,差异有统计学意义(F=54.99,P＜0.01).结论MR灌注成像能够显示MELAS综合征患者发作期的脑血流改变,提示病灶区处于高灌注状态.
目的 探討MELAS綜閤徵患者的MR腦血流灌註異常特徵.方法 對13例確診的MELAS綜閤徵患者和13名對照組受試者行流速敏感交替反轉恢複免除獨立T1測量(FAIREST)序列掃描,通過後處理生成腦血流量(CBF)圖,分彆測量他們的雙側基底節區、丘腦、顥葉和枕葉的相對腦血流量(rCBF)值,採用多元迴歸法分析對照組中測量部位和側彆對rCBF值的影響,將對照組、MELAS綜閤徵組非病竈區和病竈區的rCBF值採用單因素方差分析進行比較.結果 對照組左側基底節區、丘腦、顳葉和枕葉的rCBF值分彆為0.83±0.23、1.17±0.30、0.93±0.28和1.11±0.25,右側基底節區、丘腦、顳葉和枕葉的rCBF值分彆為0.77±0.15、1.03±0,34、1.06±0.23和1.09±0.23,多元同歸分析結果顯示,對照組不同測量部位和側彆對于rCBF值的影響無統計學意義(P＞0.05).對照組感興趣區的rCBF值為1.00±0.28,MELAS組綜閤徵非病竈區和病竈區的rCBF值分彆為1.01±0.31和1.95±0.43,MELAS綜閤徵組病竈區的rCBF值大于非病竈區和對照組,差異有統計學意義(F=54.99,P＜0.01).結論MR灌註成像能夠顯示MELAS綜閤徵患者髮作期的腦血流改變,提示病竈區處于高灌註狀態.
목적 탐토MELAS종합정환자적MR뇌혈류관주이상특정.방법 대13례학진적MELAS종합정환자화13명대조조수시자행류속민감교체반전회복면제독립T1측량(FAIREST)서렬소묘,통과후처리생성뇌혈류량(CBF)도,분별측량타문적쌍측기저절구、구뇌、호협화침협적상대뇌혈류량(rCBF)치,채용다원회귀법분석대조조중측량부위화측별대rCBF치적영향,장대조조、MELAS종합정조비병조구화병조구적rCBF치채용단인소방차분석진행비교.결과 대조조좌측기저절구、구뇌、섭협화침협적rCBF치분별위0.83±0.23、1.17±0.30、0.93±0.28화1.11±0.25,우측기저절구、구뇌、섭협화침협적rCBF치분별위0.77±0.15、1.03±0,34、1.06±0.23화1.09±0.23,다원동귀분석결과현시,대조조불동측량부위화측별대우rCBF치적영향무통계학의의(P＞0.05).대조조감흥취구적rCBF치위1.00±0.28,MELAS조종합정비병조구화병조구적rCBF치분별위1.01±0.31화1.95±0.43,MELAS종합정조병조구적rCBF치대우비병조구화대조조,차이유통계학의의(F=54.99,P＜0.01).결론MR관주성상능구현시MELAS종합정환자발작기적뇌혈류개변,제시병조구처우고관주상태.
Objective To detect the changes of cerebral perfusion in patients with MELAs syndrome by using MR perfusion technique.Methods Thirteen patients with MELAS syndrome and 13 controls with normal neurological conditions were scanned with the sequence of flow-sensitive alternating inversion recovery exempting separate T1 measurement(FAIREST).Their rCBF values were obtained in regions of bilateral basilar nuclei and thalami,as well as bilateral temporal lobes and occipital lobes.Regression analysis was carried out to determine the effect of location and side on the measurement of rCBF in controls.One-way ANOVA was conducted to compare rCBF values among the control group.the lesion ROIs and normal ROIs of the MELAS syndrome group.Results The values of rCBF were 0.83±0.23,1.17±0.30.0.93±0.28,and 1.11±0.25 for the left basilar ganglia,thalamus,temporal lobe,and occipital lobe respectively,while they were 0.77±0.15,1.03±0.34,1.06±0.23,and 1.09±0.23 for the right basilar ganglia,thalamus,temporal lobe.and occipital lobe respectively.Regression analysis revealed no effect of location and side on the rCBF (P＞0.05).The rCBF value for control group was 1.00±0.28,while it was 1.01±0.31 for the normal ROIs and 1.95±0.43 for the lesion ROIs in the MELAS syndrome group(F=54.99.P＜0.01).The rCBF of the lesion ROIs in the MELAS syndrome group was significantly higher than the normal ROIs and the control group.Conclusion CBF maps can reveal changes of cerebral blood flow in patients with ietal MELAS,which suggests increased perfusion in the stroke-like lesions.
