中国医药
中國醫藥
중국의약
CHINA MEDICINE
2012年
7期
868-869
,共2页
十二指肠乳头切开术后%熊去氧胆酸%中药
十二指腸乳頭切開術後%熊去氧膽痠%中藥
십이지장유두절개술후%웅거양담산%중약
Endoscopic papillotomy%Ursodesoxycholic acid%Traditional Chinese medicine
目的 观察熊去氧胆酸胶囊联合中药在防治十二指肠乳头切开术后结石复发中的作用.方法 选择1999年1月至2009年10月间在我院消化内科行十二指肠乳头切开术治疗胆管结石的患者210例,完全随机分为4组,联合用药组(55例)血脂(3.40±0.34) mmol/L;单纯口服熊去氧胆酸胶囊组(50例)血脂(4.17±0.29) mmol/L;单纯口服中药组(50例)血脂(4.02 ±0.15) mmol/L;对照组(55例)血脂(3.76±0.26) mmol/L.联合用药组低脂饮食同时加服熊去氧胆酸胶囊,10mg/(kg·d),口服,2次/d,金玉排石汤100ml,2次/d,服用半年.单纯口服熊去氧胆酸胶囊组,低脂饮食加熊去氧胆酸胶囊,10mg/( kg·d),口服,2次/d,服用半年.单纯口服中药组,低脂饮食加金玉排石汤,100ml,2次/d,服用半年.对照组,给予低脂饮食.随访半年,每6个月行上腹部B超,比较复发率.结果 联合用药组结石复发1例,复发率为1.8％;单纯服用熊去氧胆酸胶囊结石复发8例,复发率为16.0％；单纯口服中药组结石复发8例,复发率16.0％,对照组复发19例,复发率为34.5％,联合用药组复发率明显低于对照组、单纯口服中药组和单纯口服熊去氧胆酸胶囊组,差异有统计学意义(均P＜0.05).结论 服用熊去氧胆酸胶囊联合中药可有效预防结石的复发,熊去氧胆酸胶囊降低血清胆固醇水平及中药利胆排石可能是其预防复发的机制之一.
目的 觀察熊去氧膽痠膠囊聯閤中藥在防治十二指腸乳頭切開術後結石複髮中的作用.方法 選擇1999年1月至2009年10月間在我院消化內科行十二指腸乳頭切開術治療膽管結石的患者210例,完全隨機分為4組,聯閤用藥組(55例)血脂(3.40±0.34) mmol/L;單純口服熊去氧膽痠膠囊組(50例)血脂(4.17±0.29) mmol/L;單純口服中藥組(50例)血脂(4.02 ±0.15) mmol/L;對照組(55例)血脂(3.76±0.26) mmol/L.聯閤用藥組低脂飲食同時加服熊去氧膽痠膠囊,10mg/(kg·d),口服,2次/d,金玉排石湯100ml,2次/d,服用半年.單純口服熊去氧膽痠膠囊組,低脂飲食加熊去氧膽痠膠囊,10mg/( kg·d),口服,2次/d,服用半年.單純口服中藥組,低脂飲食加金玉排石湯,100ml,2次/d,服用半年.對照組,給予低脂飲食.隨訪半年,每6箇月行上腹部B超,比較複髮率.結果 聯閤用藥組結石複髮1例,複髮率為1.8％;單純服用熊去氧膽痠膠囊結石複髮8例,複髮率為16.0％；單純口服中藥組結石複髮8例,複髮率16.0％,對照組複髮19例,複髮率為34.5％,聯閤用藥組複髮率明顯低于對照組、單純口服中藥組和單純口服熊去氧膽痠膠囊組,差異有統計學意義(均P＜0.05).結論 服用熊去氧膽痠膠囊聯閤中藥可有效預防結石的複髮,熊去氧膽痠膠囊降低血清膽固醇水平及中藥利膽排石可能是其預防複髮的機製之一.
목적 관찰웅거양담산효낭연합중약재방치십이지장유두절개술후결석복발중적작용.방법 선택1999년1월지2009년10월간재아원소화내과행십이지장유두절개술치료담관결석적환자210례,완전수궤분위4조,연합용약조(55례)혈지(3.40±0.34) mmol/L;단순구복웅거양담산효낭조(50례)혈지(4.17±0.29) mmol/L;단순구복중약조(50례)혈지(4.02 ±0.15) mmol/L;대조조(55례)혈지(3.76±0.26) mmol/L.연합용약조저지음식동시가복웅거양담산효낭,10mg/(kg·d),구복,2차/d,금옥배석탕100ml,2차/d,복용반년.단순구복웅거양담산효낭조,저지음식가웅거양담산효낭,10mg/( kg·d),구복,2차/d,복용반년.단순구복중약조,저지음식가금옥배석탕,100ml,2차/d,복용반년.대조조,급여저지음식.수방반년,매6개월행상복부B초,비교복발솔.결과 연합용약조결석복발1례,복발솔위1.8％;단순복용웅거양담산효낭결석복발8례,복발솔위16.0％；단순구복중약조결석복발8례,복발솔16.0％,대조조복발19례,복발솔위34.5％,연합용약조복발솔명현저우대조조、단순구복중약조화단순구복웅거양담산효낭조,차이유통계학의의(균P＜0.05).결론 복용웅거양담산효낭연합중약가유효예방결석적복발,웅거양담산효낭강저혈청담고순수평급중약리담배석가능시기예방복발적궤제지일.
Objective To evaluate the effect of ursodesoxycholic acid(UDCA) and traditional Chinese medicine on the relapse of cholelithiasis after endoscopic papillotomy.Methods Two hundred patients treated with endoscopic papillotomy from 1999 to 2009 were randomly divided into trial group and control group.The cases in trial group were 55.The rest were randomly divided into three groups again.50 patients taking UDCA after operation,50patients taking traditional Chinese medicine and 55 patients were not given any medicines.All patients were followed up for one year to observe the calculus recrudescence.Results The recurrence rate was 1.8％(1/55) in trial group.16.0％(8/50)in group taking UDCA,16.0％(8/50) in group taking traditional Chinese medicine and 34.5％(19/55) in the group did not take medicaition(P ＜ 0.05).Conclusions UDCA and traditional Chinese medicine can effectively prevent the stone recrudescence.One of the possible mechanisms is that UDCA can reduce the level of serum cholesterol.
