CAJ | 학술논문

目的总结继发性周围神经恶性病变18F-脱氧葡萄糖(FDG) PET/CT影像特征,探讨18F-FDG PET/CT在继发性周围神经恶性病变中的应用价值.方法回顾性分析经病理检查或长期随访证实的8例周围神经恶性病变患者18F-FDG PET/CT影像学资料,比较继发性周围神经恶性病变与健侧周围神经PET/CT表现的异同,利用SPSS 10.0软件对受累的周围神经及健侧对应部位周围神经的最大标准摄取值(SUVmax)行配对t检验.结果 8例继发性周围神经恶性病变患者共发现病灶12个,PET示病灶均沿神经束或椎间孔走行,且表现为束条形、根块状或结节状FDG代谢异常增高,SUVmax为6.86±3.87,同机CT病灶表现为沿神经束或神经根管走行之束条形、根块状或结节状软组织密度影,病灶均与周围软组织及邻近脂肪间隙分界不清;健侧对应部位周围神经在18F-FDG PET及同机CT上均未见明确显影,其SUVmax为1.10±0.46;继发性周围神经恶性病变与健侧周围神经SUVmax比较,差异有统计学意义(t=9.231,P＜0.001).结论 18F-FDG PET/CT可以准确反映肿瘤对周围神经的侵犯及转移,显示病灶的大小、形态、分布及肿瘤活性,对继发性周围神经恶性病变的诊断具有重要价值.
목적 총결계발성주위신경악성병변18F-탈양포도당(FDG) PET/CT영상특정,탐토18F-FDG PET/CT재계발성주위신경악성병변중적응용개치.방법 회고성분석경병리검사혹장기수방증실적8례주위신경악성병변환자18F-FDG PET/CT영상학자료,비교계발성주위신경악성병변여건측주위신경PET/CT표현적이동,이용SPSS 10.0연건대수루적주위신경급건측대응부위주위신경적최대표준섭취치(SUVmax)행배대t검험.결과 8례계발성주위신경악성병변환자공발현병조12개,PET시병조균연신경속혹추간공주행,차표현위속조형、근괴상혹결절상FDG대사이상증고,SUVmax위6.86±3.87,동궤CT병조표현위연신경속혹신경근관주행지속조형、근괴상혹결절상연조직밀도영,병조균여주위연조직급린근지방간극분계불청;건측대응부위주위신경재18F-FDG PET급동궤CT상균미견명학현영,기SUVmax위1.10±0.46;계발성주위신경악성병변여건측주위신경SUVmax비교,차이유통계학의의(t=9.231,P＜0.001).결론 18F-FDG PET/CT가이준학반영종류대주위신경적침범급전이,현시병조적대소、형태、분포급종류활성,대계발성주위신경악성병변적진단구유중요개치.
Objective To investigate the characteristics and diagnostic value of 18F-fluorodeoxyglucose (FDG) PET/CT in patients with secondary malignant peripheral nerve lesions. Methods 18F-FDG PET/CT studies of 8 cases of secondary malignant peripheral nerve lesions confirmed by histopathology or follow-up were analyzed retrospectively. The maximum standardized uptake value ( SUVmax ) of infiltrating peripheral nerves and contralateral normal peripheral nerves was measured and compared with their morphological appearances on CT. Paired student t-test was performed by SPSS 10.0. Results Twelve secondary malignant peripheral nerve lesions with high 18F-FDG metabolism were found in 8 cases. On PET imaging,the lesions distributed along the neurovascular tissues or intervertebral foramina with appearances resembling those of fibre bundles,radices or nodes on PET but no density differences with the surrounding soft tissue or fat planes on CT. The SUVmax was 6.86 ± 3.87. The contralateral normal peripheral nerves showed no abnormal 18F-FDG uptake with a SUVmax of 1.10 ±0.46,which was significantly different from that of the secondary malignant peripheral nerve lesions (t = 9.231,P ＜ 0.001 ). Conclusion 18 F-FDG PET/CT may be useful in locating the secondary malignant peripheral nerve lesions and in assessing its regional infiltration.