中华耳鼻咽喉头颈外科杂志
中華耳鼻嚥喉頭頸外科雜誌
중화이비인후두경외과잡지
CHINESE JOURNAL OF OTORHINOLARYNGOLOGY HEAD AND NECK SURGERY
2009年
4期
302-306
,共5页
张罗%罗雪瑞%刘承耀%赵岩%韩德民
張囉%囉雪瑞%劉承耀%趙巖%韓德民
장라%라설서%류승요%조암%한덕민
一氧化氮%口呼吸%鼻%呼气
一氧化氮%口呼吸%鼻%呼氣
일양화담%구호흡%비%호기
Nitric oxide%Mouth breathing%Nose%Exhalation
目的 呼出气中一氧化氮(nitric oxide,NO)含量是反映上下气道炎性反应程度的指标,为此测定健康成人经口和经鼻呼出气中NO含量,得到相应的参考值并分析其影响因素.方法 健康成人80名(男20名,女60名),年龄18~44岁,中位数年龄25岁.采用耐尔斯(NIOX)呼出气NO测定系统,分别测定口呼出气和鼻呼出气中NO含量,进而采用多元线性回归分析法,研究性别、年龄、身高、体质量指数(body mass index,BMI)、测量时间和环境NO含量对检测结果的影响.结果 ①健康成人121呼出气NO含量为(17±8)×10-9[95%可信区间:(0.3~33)×10-9];鼻呼出气NO含量为(819±211)×10-9[95%可信区间:(400~1238)×10-9].②口呼出气NO含量与受试者身高呈正相关,回归方程:Y(口呼出气NO含量)=-58.524+0.457X(身高,cm),t=-2.985,P<0.01.受试者的年龄、性别、BMI、测量时间和环境NO含量对口呼出气NO含量无显著影响.③健康成人鼻呼出气NO含量与年龄呈正相关,与性别呈负相关,回归方程:Y(鼻呼出气NO含量)=760.245+9.417X,(年龄)-111.222X2(性别),t=5.188,P<0.01.患者鼻腔左右侧别、身高和BMI、测量时间和环境NO含量对鼻呼出气NO含量无显著影响.结论 口、鼻呼出气中NO含量测定操作简便、灵敏度较高,是一种非侵袭性的临床检测手段,正常参考值可受到受试者性别、身高和年龄等因素的影响.
目的 呼齣氣中一氧化氮(nitric oxide,NO)含量是反映上下氣道炎性反應程度的指標,為此測定健康成人經口和經鼻呼齣氣中NO含量,得到相應的參攷值併分析其影響因素.方法 健康成人80名(男20名,女60名),年齡18~44歲,中位數年齡25歲.採用耐爾斯(NIOX)呼齣氣NO測定繫統,分彆測定口呼齣氣和鼻呼齣氣中NO含量,進而採用多元線性迴歸分析法,研究性彆、年齡、身高、體質量指數(body mass index,BMI)、測量時間和環境NO含量對檢測結果的影響.結果 ①健康成人121呼齣氣NO含量為(17±8)×10-9[95%可信區間:(0.3~33)×10-9];鼻呼齣氣NO含量為(819±211)×10-9[95%可信區間:(400~1238)×10-9].②口呼齣氣NO含量與受試者身高呈正相關,迴歸方程:Y(口呼齣氣NO含量)=-58.524+0.457X(身高,cm),t=-2.985,P<0.01.受試者的年齡、性彆、BMI、測量時間和環境NO含量對口呼齣氣NO含量無顯著影響.③健康成人鼻呼齣氣NO含量與年齡呈正相關,與性彆呈負相關,迴歸方程:Y(鼻呼齣氣NO含量)=760.245+9.417X,(年齡)-111.222X2(性彆),t=5.188,P<0.01.患者鼻腔左右側彆、身高和BMI、測量時間和環境NO含量對鼻呼齣氣NO含量無顯著影響.結論 口、鼻呼齣氣中NO含量測定操作簡便、靈敏度較高,是一種非侵襲性的臨床檢測手段,正常參攷值可受到受試者性彆、身高和年齡等因素的影響.
목적 호출기중일양화담(nitric oxide,NO)함량시반영상하기도염성반응정도적지표,위차측정건강성인경구화경비호출기중NO함량,득도상응적삼고치병분석기영향인소.방법 건강성인80명(남20명,녀60명),년령18~44세,중위수년령25세.채용내이사(NIOX)호출기NO측정계통,분별측정구호출기화비호출기중NO함량,진이채용다원선성회귀분석법,연구성별、년령、신고、체질량지수(body mass index,BMI)、측량시간화배경NO함량대검측결과적영향.결과 ①건강성인121호출기NO함량위(17±8)×10-9[95%가신구간:(0.3~33)×10-9];비호출기NO함량위(819±211)×10-9[95%가신구간:(400~1238)×10-9].②구호출기NO함량여수시자신고정정상관,회귀방정:Y(구호출기NO함량)=-58.524+0.457X(신고,cm),t=-2.985,P<0.01.수시자적년령、성별、BMI、측량시간화배경NO함량대구호출기NO함량무현저영향.③건강성인비호출기NO함량여년령정정상관,여성별정부상관,회귀방정:Y(비호출기NO함량)=760.245+9.417X,(년령)-111.222X2(성별),t=5.188,P<0.01.환자비강좌우측별、신고화BMI、측량시간화배경NO함량대비호출기NO함량무현저영향.결론 구、비호출기중NO함량측정조작간편、령민도교고,시일충비침습성적림상검측수단,정상삼고치가수도수시자성별、신고화년령등인소적영향.
Objective To obtain the normal values of nitric oxide (NO) exhaled throuth nose and mouth in healthy Chinese adults by measuring exhaled NO and analyzing the influencing factors. Methods Eighty healthy Chinese adults were recruited, including 20 males and 60 females. The age ranged from 18 to 44 years old. Chemiluminescence analyzer (NIOX) was used to obtain the values of exhaled NO throuth nose and mouth. The relativity between NO and gender, age, height, body mass index, time, ambient NO were analyzed with Multiple linear regression and correlation. Results Exhaled NO values were (17±8)×10-9 and correlated significantly with height. Regression equation: Y(exhaled nitric oxide) = -58. 524 +0.457X(height, cm),t = -2.985,P <0.01. Transnasal NO values were (819±211) ×10-9 and correlated significantly with age and gender. Regression equation: Y(nasal nitric oxide) = 760. 245 +9.417X1(age) -111. 222X2(gender),t=5. 188,P<0.01. Conclusions Exhaled NO normal values were 17×10-9 and Transnasal NO normal values were 819 × 10-9. Exhaled NO correlated positively with height. Transnasal NO correlated positively with age and negatively with gender.