CAJ | 학술논문

目的探讨胃肠道间质瘤(GIST)病理学因素与预后的相关性.方法应用免疫组织化学Envision法对91例GIST进行CD117、CD34SMA、S-100、Ki-67的标记,应用SPSS12.0软件分析肿瘤的部位、大小、出血、坏死、间质黏液、核分裂象及Ki-67与预后的相关性.结果 91例GIST CD117、CD34、SMA、S-100的阳性率分别为:80.21%、73.63%、34.07%、7.69%,肿瘤大小、核分裂象、Ki-67的表达与预后差异有显著相关性,出血、坏死、间质黏液、CD117的表达与预后无显著相关性.结论肿瘤大小、核分裂象、Ki-67的表达与预后有相关性.Ki-67的表达相对于核分裂象在判断肿瘤生物学行为方面是一个更为准确的指标,Flecther分级法是一种值得推广的分级方法.
목적 탐토위장도간질류(GIST)병이학인소여예후적상관성.방법 응용면역조직화학Envision법대91례GIST진행CD117、CD34SMA、S-100、Ki-67적표기,응용SPSS12.0연건분석종류적부위、대소、출혈、배사、간질점액、핵분렬상급Ki-67여예후적상관성.결과 91례GIST CD117、CD34、SMA、S-100적양성솔분별위:80.21%、73.63%、34.07%、7.69%,종류대소、핵분렬상、Ki-67적표체여예후차이유현저상관성,출혈、배사、간질점액、CD117적표체여예후무현저상관성.결론 종류대소、핵분렬상、Ki-67적표체여예후유상관성.Ki-67적표체상대우핵분렬상재판단종류생물학행위방면시일개경위준학적지표,Flecther분급법시일충치득추엄적분급방법.
Objective To investigate the correlation of pathology factors and prognosis of gastrointestinal stroma tumors (GIST). Methods The expression of CD117, CD34, SMA, S-100 and Ki-67 in 91 GIST cases were studied by Envision method of immunohistocbemistory;Sequently, the relationship of the location, the size, the hemorrhage, cellular necrosis, stroma mucus, the mitosis, Ki-67 expression and the prognosis were analyzed by SPSS 12.0. Results The positive rate of CD117, CD34, SMA, S-100 were 80.21%, 73.63 %, 34.07 %, 7.69 % respectively. There had significant difference between the location, the mitosis, Ki-67 expression and the prognosis; but no significant difference between the location, the hemorrhage, cellular necrosis, stroma mucus, CD117 expression and the prognosis. Conclusion The tumor's size, mitosis, and Ki-67 expression are associated with prognosis; CD117 expression and prognosis. Even more, Ki-67 expression may be a more precise factor to judge the tumor's biological behaviour compared to the mitosis. As a wally classified method, the Flecther classification is worth to spread.