河南师范大学学报（自然科学版）
河南師範大學學報（自然科學版）
하남사범대학학보（자연과학판）
JOURNAL OF HENAN NORMAL UNIVERSITY(NATURAL SCIENCE)
2009年
6期
103-107
,共5页
陈晓芳%李丛鑫%王鹏业%王渭池
陳曉芳%李叢鑫%王鵬業%王渭池
진효방%리총흠%왕붕업%왕위지
CRAC通道%Orai1蛋白%STIM1蛋白
CRAC通道%Orai1蛋白%STIM1蛋白
CRAC통도%Orai1단백%STIM1단백
CRAC channel%Orail proteint STIM1 protein
Ca~(2+)释放激活Ca~(2+)(CRAC)通道是位于非兴奋性细胞质膜上的慢Ca~(2+)通道,是非兴奋性细胞(尤其T淋巴细胞和HEK 293细胞)中胞外Ca~(2+)进入细胞内的主要途径.Ca~(2+)内流是T淋巴细胞激活的最重要的生理生化特征之一.Orai1蛋白单体是组成CRAC通道的亚基,4个Orai1蛋白亚基构成一个四聚体CRAC通道.内质网Ca~(2+)浓度的降低使得STIM1发生定向运动并产生聚集,从而激活了CRAC通道.STIM1蛋白把内质网Ca~(2+)的损耗与CRAC通道上的Ca~(2+)内流联系起来,行使了Ca~(2+)浓度感受器的功能.
Ca~(2+)釋放激活Ca~(2+)(CRAC)通道是位于非興奮性細胞質膜上的慢Ca~(2+)通道,是非興奮性細胞(尤其T淋巴細胞和HEK 293細胞)中胞外Ca~(2+)進入細胞內的主要途徑.Ca~(2+)內流是T淋巴細胞激活的最重要的生理生化特徵之一.Orai1蛋白單體是組成CRAC通道的亞基,4箇Orai1蛋白亞基構成一箇四聚體CRAC通道.內質網Ca~(2+)濃度的降低使得STIM1髮生定嚮運動併產生聚集,從而激活瞭CRAC通道.STIM1蛋白把內質網Ca~(2+)的損耗與CRAC通道上的Ca~(2+)內流聯繫起來,行使瞭Ca~(2+)濃度感受器的功能.
Ca~(2+)석방격활Ca~(2+)(CRAC)통도시위우비흥강성세포질막상적만Ca~(2+)통도,시비흥강성세포(우기T림파세포화HEK 293세포)중포외Ca~(2+)진입세포내적주요도경.Ca~(2+)내류시T림파세포격활적최중요적생리생화특정지일.Orai1단백단체시조성CRAC통도적아기,4개Orai1단백아기구성일개사취체CRAC통도.내질망Ca~(2+)농도적강저사득STIM1발생정향운동병산생취집,종이격활료CRAC통도.STIM1단백파내질망Ca~(2+)적손모여CRAC통도상적Ca~(2+)내류련계기래,행사료Ca~(2+)농도감수기적공능.
Calcium-release-activated calcium (CRAC) channel is a slow Ca~(2+) channel,which locates in the plasma membrane in non-excitable cells.CRAC channel is the major Ca~(2+) entry pathway in non-excitable cells,especially in T lymphocytes and HEK 293 cells.Ca~(2+) influx is one of the most important physiological-biochemical characteristics of T lymphocytes cell.Orail is the subunit of CRAC channel,and four Orail monomers constitute one tetrameric CRAC channel.STIM1 functions as the missing link between endoplasmic reticulum Ca~(2+) depletion and CRAC influx.At present,STIM1 has been widely accepted as a Ca~(2+) sensor that relays the store depletion information to plasma membrane and thus to activate CRAC channel.
