CAJ | 학술논문

瘢痕疙瘩发病机制不明,治疗比较困难,临床多采用综合疗法.外科手术切除联合放射治疗,或者联合瘢痕内注射糖皮质激素是治疗瘢痕疙瘩的一线疗法.放疗通常有浅层X线、电子束,其致癌性通常较小.硅凝胶片和压力疗法通常作为基础性辅助治疗,对不同病期的瘢痕疙瘩均有一定疗效,表现为瘢痕变软、变平,主观症状得到改善.抗瘢痕疙瘩药物主要包括积雪草苷和α-积雪草苷乳膏、5%咪喹莫特乳膏等.基因治疗和某些生物制剂可能是瘢痕疙瘩治疗的发展方向.个性化评估瘢痕疙瘩患者的病情,综合运用以上治疗方法可以较好地减轻皮损.
반흔흘탑발병궤제불명,치료비교곤난,림상다채용종합요법.외과수술절제연합방사치료,혹자연합반흔내주사당피질격소시치료반흔흘탑적일선요법.방료통상유천층X선、전자속,기치암성통상교소.규응효편화압력요법통상작위기출성보조치료,대불동병기적반흔흘탑균유일정료효,표현위반흔변연、변평,주관증상득도개선.항반흔흘탑약물주요포괄적설초감화α-적설초감유고、5%미규막특유고등.기인치료화모사생물제제가능시반흔흘탑치료적발전방향.개성화평고반흔흘탑환자적병정,종합운용이상치료방법가이교호지감경피손.
The pathogenesis of keloids remains obscure, and its treatment is troublesome.Comprehensive therapy is usually applied for its management in clinical settings.Surgical removal combined with radiotherapy or intralesional glucocorticoids is the first-line treatment for keloids.Radiotherapy, which includes superficial X ray therapy, electron beam therapy, etc, often has little carcinogenicity.Sillicon gel sheet and pressure therapy usually serve as the basic adjunctive treatment of keloids, which can soften and flatten keloids and improve subjective symptoms and have shown favorable efficacy in all stages of keloids.Effective drugs for keloids mainly include asiaticoside, alpha asiaticoside cream, imiquimod 5% cream, etc.Gene therapy as well as biological preparations may have an inviting prospect for the management of keloids.Satisfactory outcomes may be achieved by combined modality therapy with the above regimens following individual evaluation of eonditions in patients with keloids.